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All Journal Jurnal Kedokteran STM (Sains dan Teknologi Medik)
Kadri, Sayed Muhammad
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Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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HUBUNGAN EKSPRESI PD-L1 DAN DENSITAS TILS PADA SUBTIPE KARSINOMA OVARIUM: CORRELATION OF PD-L1 EXPRESSION AND TILS DENSITY IN OVARIAN CARCINOMA SUBTYPES Kadri, Sayed Muhammad; Mariedina, Causa Trisna; Betty; Laksmi, Lidya Imelda; Lubis, Nadjib Dahlan
Jurnal Kedokteran STM (Sains dan Teknologi Medik) Vol. 8 No. 2 (2025): Juli 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/stm.v8i2.926

Abstract

Background: PD-L1 and tumor-infiltrating lymphocytes (TILs) are essential components of the tumor microenvironment, playing key roles in modulating immune responses against ovarian carcinoma. However, the relationship between these two markers remains underexplored, especially across different histopathological subtypesMethods: A cross-sectional analytical study was conducted on 40 ovarian carcinoma cases using immunohistochemistry. PD-L1 expression and TIL density were evaluated in both intratumoral and stromal compartments. The Somers’ D test was used to analyze the correlation between variables.Results: Most patients were aged 40–50 years and presented with stage I disease. The predominant histopathological subtype was serous carcinoma. Intratumoral and stromal TIL densities were mostly low (77.5% and 72.5%, respectively). Positive intratumoral PD-L1 expression was observed in only 5% of cases, while no stromal PD-L1 expression was detected. No statistically significant correlation was found between PD-L1 expression and TIL density, either overall or by subtype.Conclusion: No significant correlation was observed between PD-L1 expression and TIL density in ovarian carcinoma subtypes. The variability in their expression suggests immune microenvironment heterogeneity, supporting the need for separate evaluation of these biomarkers and individualized approaches to immunotherapy. AbstrakLatar Belakang: PD-L1 dan TILs merupakan komponen utama dalam mikrolingkungan tumor yang berperan penting dalam regulasi respons imun terhadap karsinoma ovarium. Hubungan antara keduanya masih jarang dikaji, khususnya pada berbagai subtipe histopatologi.Tujuan: Menilai hubungan antara ekspresi PD-L1 dan densitas TILs pada beberapa subtipe karsinoma ovarium.Metode: Penelitian cross-sectional analitik pada 40 kasus karsinoma ovarium menggunakan pewarnaan imunohistokimia. Ekspresi PD-L1 dan densitas TILs dianalisis pada area intratumoral dan stromal. Uji korelasi Somers’ D digunakan untuk menilai hubungan antar variabel.Hasil: Mayoritas pasien berusia 40–50 tahun dan berada pada stadium klinis I, dengan subtipe terbanyak adalah serous carcinoma. Densitas TILs intratumoral dan stromal sebagian besar tergolong rendah (77,5% dan 72,5%). Ekspresi PD-L1 intratumoral positif ditemukan pada 5% kasus, sedangkan ekspresi PD-L1 stromal tidak ditemukan. Tidak terdapat hubungan yang bermakna antara ekspresi PD-L1 dan densitas TILs, baik secara keseluruhan maupun berdasarkan subtipe.Kesimpulan:Tidak ditemukan korelasi signifikan antara ekspresi PD-L1 dan densitas TILs pada subtipe karsinoma ovarium. Variasi pola ekspresi antar subtipe mencerminkan heterogenitas imun tumor, sehingga diperlukan evaluasi terpisah PD-L1 dan TILs sebagai biomarker serta pendekatan individualisasi dalam terapi imun.
HUBUNGAN DERAJAT TILS INTRATUMORAL DAN STROMAL TERHADAP SUBTIPE TUMOR MUCINOUS OVARIUM DI RSUP H. ADAM MALIK MEDAN: ASSOCIATION BETWEEN INTRATUMORAL AND STROMAL TILS DEGREES AND MUCINOUS OVARIAN TUMOR SUBTYPES AT H. ADAM MALIK GENERAL HOSPITAL MEDAN Kadri, Sayed Muhammad; Delyuzar; Intan, T. Kemala; Soekimin; Lukito, Joko S; Chrestella, Jessy
Jurnal Kedokteran STM (Sains dan Teknologi Medik) Vol. 9 No. 1 (2026): Januari 2026
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/stm.v9i1.987

Abstract

Mucinous ovarian tumors represent a distinct subtype of epithelial ovarian neoplasms with varying biological behaviors and histopathological features. Tumor-infiltrating lymphocytes (TILs), both intratumoral and stromal, have emerged as prognostic biomarkers in various malignancies, including ovarian cancer. Objective of this study is to analyze the association between intratumoral and stromal TILs degrees with mucinous ovarian tumor subtypes at H. Adam Malik General Hospital, Medan. A cross-sectional analytic study was conducted on 42 formalin-fixed paraffin-embedded tissue samples diagnosed as mucinous ovarian tumors. TILs were assessed on H&E-stained slides using criteria from the International TILs Working Group. Statistical analysis employed Chi-square tests. Results of this study show that high intratumoral TILs were predominantly found in benign mucinous tumors, while low intratumoral TILs were common in malignant cases (p = 0.002). Similarly, high stromal TILs were more frequent in benign subtypes, and low stromal TILs were significantly associated with malignant subtypes (p = 0.000). Conclusion of this study is that there is a significant association between intratumoral and stromal TILs degrees and the histological subtypes of mucinous ovarian tumors. Higher TILs levels are more frequently found in benign tumors, suggesting a potential role as a prognostic indicator. AbstrakTumor ovarium mucinous merupakan salah satu subtipe neoplasma epitel ovarium dengan perilaku biologis dan karakter histopatologi yang bervariasi. Tumor-infiltrating lymphocytes (TILs), baik intratumoral maupun stromal, telah diidentifikasi sebagai biomarker prognostik pada berbagai jenis keganasan, termasuk kanker ovarium. Tujuan penelitian ini adalah untuk mengetahui hubungan antara derajat TILs intratumoral dan stromal dengan subtipe histopatologi tumor mucinous ovarium di RSUP H. Adam Malik Medan. Penelitian analitik potong lintang dilakukan terhadap 42 sampel jaringan tumor mucinous ovarium yang telah difiksasi formalin dan diblok parafin. Penilaian TILs dilakukan pada preparat hematoksilin-eosin (HE) berdasarkan pedoman dari International TILs Working Group. Analisis statistik menggunakan uji Chi-square. Hasil penelitian memperlihatkan bahwa derajat TILs intratumoral tinggi paling banyak ditemukan pada tumor mucinous jinak, sedangkan TILs rendah dominan pada tumor mucinous ganas (p = 0,002). Hal serupa ditemukan pada TILs stromal, di mana TILs tinggi lebih sering pada tumor jinak, dan TILs rendah lebih sering pada subtipe ganas (p = 0,000). Kesimpulan penelitian ini adalah terdapat hubungan bermakna antara derajat TILs intratumoral dan stromal dengan subtipe histopatologi tumor mucinous ovarium. Derajat TILs yang lebih tinggi berhubungan dengan subtipe yang lebih jinak, sehingga berpotensi sebagai indikator prognosis.
Co-Authors Betty Chrestella, Jessy Delyuzar, Delyuzar Intan, T. Kemala Laksmi, Lidya Imelda Lukito, Joko S Mariedina, Causa Trisna Nadjib Dahlan Lubis Soekimin