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BREAST CANCER PROFILE IN VERY YOUNG WOMEN AT HAJI ADAM MALIK GENERAL HOSPITAL MEDAN Ginting, Nichitri Agina; Betty
Sumatera Medical Journal Vol. 3 No. 3 (2020): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v3i3.3686

Abstract

Abstract. Breast cancer is the most kind of cancer that happens to women, and it’s one of the cancer that can cause the major death in the world and in Indonesia. Breast cancer cases at age are very young tend to have lower percentages of old age, but have a bad prognosis. Family history of breast cancer because of the BRCA1 and BRCA2 mutation . Objective. The aim of this research is to study about breast cancer very young age profile in H. Adam Malik Medan General Hospital. From 2016-2018 based on age, family history and grading histology. Methods. In this descriptive research with cross-sectional study, the sample were collected from medical record of breast cancer patient in H. Adam Malik Medan General Hospital. This research use total sampling method and matched with inclusion and exclusion criteria. Results. Total of the sample is 160 subject. The majority of age group is 31-35 year’s old (81 subject or 51,0%). The majority of age menarche group is <12 year’s old (104 subject or 65,5%). Do not have family history (82 subject or 51,3%), and have a family history just found (78 subject or 48,8%). The majority of grading histology is grade 3 (68 subject or 42,5%). Conclusion. Sufferers of breast cancer at very young age is quite a lot with grade 3 on grading histology.Keyword: breast cancer, very young age, family history. Abstrak. Latar Belakang. Kanker payudara merupakan kanker yang paling sering terjadi pada wanita, dan merupakan salah satu kanker yang dapat menyebabkan kematian utama di dunia dan di Indonesia. Kasus kanker payudara pada usia sangat muda cenderung memiliki presentase yang lebih rendah diantara usia tua, namun memiliki prognosis yang lebih buruk. Riwayat keluarga pada kanker payudara dikarenakan adanya mutasi BRCA1 dan BRCA2. Tujuan. Mengetahui profil kanker payudara wanita pada usia sangat muda di Rumah Sakit Umum Pusat Haji Adam Malik Medan. Tahun 2016-2018 berdasarkan usia, riwayat keluarga dan grading histologi. Metode. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross-sectional. Penelitian ini dilakukan menggunakan data sekunder melalui data rekam medis penderita kanker payudara di Rumah Sakit Umum Pusat Haji Adam Malik Medan. Besar sampel ditentukan dengan metode total sampling dan disesuaikan dengan kriteria inklusi dan eksklusi. Hasil. Diperoleh total 160 sampel. Kelompok usia terbanyak adalah usia 31-35 tahun sebanyak 81 penderita (51,0%). Usia menarche terbanyak pada kelompok usia <12 tahun sebanyak 104 penderita (65,5%). Tidak memiliki riwayat keluarga sebanyak 82 penderita (51,3%), dan memiliki riiwayat keluarga ditemukan sebanyak 78 penderita (48,8%). Grading histologi terbanyak adalah grade 3 sebanyak 68 penderita (42,5%). Kesimpulan. Penderita kanker payudara pada usia sangat muda cukup banyak dengan grade 3 pada grading histologi.Kata Kunci: kanker payudara, usia sangat muda, riwayat keluarga
PENERAPAN CARING DAN SPIRITUAL PERAWAT PADA PASIEN KRITIS DI RUANG ICU Husna, Elfira; Betty
Dunia Keperawatan: Jurnal Keperawatan dan Kesehatan Vol 7 No 1 (2019): Dunia Keperawatan: Jurnal Keperawatan dan Kesehatan
Publisher : School of Nursing, Faculty of Medicine and Health Science, Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (617.282 KB)

Abstract

Nursing care focuses on caring. Nurse As a professional health professional, providing servicesmust be based on a holistic function, covering all aspects of biology, psychology, sociology andspirituality. nurses provide caring services, so nurses are required to be able to meet client needsboth in healthy, sick, and critical conditions. Critical clients in addition to requiring appropriateand fast action, also can not be separated from caring needs and spiritual aspects, because incritical conditions usually clients and families are in a state of resignation and require differentactions compared to clients who are in stable condition. Critical conditions require inner calmand closeness to the God, both for patients and families to be able to go through criticalconditions in a good way. This research is a qualitative research using a phenomenologicalapproach. The purpose of this study is to explore the experience of nurses in providing caringand meeting the spiritual needs of critical patients. Participants in this study were 11 nurses whoworked in the ICU with a minimum of 1 year experience in the ICU. The data were analyzedusing a seven-stage collaizi technique so as to produce four research themes, namely: 1) servingwholeheartedly, 2) improving patient recovery, 3) impact on nurses, 4) nurse expectations forcritical patient care.
The Influence of Online Media on the Progress Prima Indonesia University Betty; Syaifuddin; Sofyan Matondang
MANAGER: Journal of Management and Administration Science Vol. 2 No. 3 (2024): MANAGER: Journal of Management and Administration Science, April 2024
Publisher : ASIAN PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58738/manager.v2i3.524

Abstract

The establishment of universities and aggressive marketing strategies in the modern era of globalization have increased competition in the higher education sector. Therefore, it is very important to know the benefits of Royal Prima Universities' marketing strategies, both online and offline, by conducting research on how affiliate marketing as a moderating variable affects brand image. The aim of this research is to explain the synergy and interdependence that exists between offline and online marketing activities in the process of forming perceptions of a university. This will be achieved through analysis involving multiple scientific disciplines. With 300 students as a sample, the data was processed using the hair formula method. In path analysis, a hypothesis testing approach is used. The test results show that offline marketing has a greater impact ratio on affiliate marketing compared to online marketing. The results also show that offline marketing has a greater ratio impact on brand image than online marketing.
HUBUNGAN EKSPRESI PD-L1 DAN DENSITAS TILS PADA SUBTIPE KARSINOMA OVARIUM: CORRELATION OF PD-L1 EXPRESSION AND TILS DENSITY IN OVARIAN CARCINOMA SUBTYPES Kadri, Sayed Muhammad; Mariedina, Causa Trisna; Betty; Laksmi, Lidya Imelda; Lubis, Nadjib Dahlan
Jurnal Kedokteran STM (Sains dan Teknologi Medik) Vol. 8 No. 2 (2025): Juli 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/stm.v8i2.926

Abstract

Background: PD-L1 and tumor-infiltrating lymphocytes (TILs) are essential components of the tumor microenvironment, playing key roles in modulating immune responses against ovarian carcinoma. However, the relationship between these two markers remains underexplored, especially across different histopathological subtypesMethods: A cross-sectional analytical study was conducted on 40 ovarian carcinoma cases using immunohistochemistry. PD-L1 expression and TIL density were evaluated in both intratumoral and stromal compartments. The Somers’ D test was used to analyze the correlation between variables.Results: Most patients were aged 40–50 years and presented with stage I disease. The predominant histopathological subtype was serous carcinoma. Intratumoral and stromal TIL densities were mostly low (77.5% and 72.5%, respectively). Positive intratumoral PD-L1 expression was observed in only 5% of cases, while no stromal PD-L1 expression was detected. No statistically significant correlation was found between PD-L1 expression and TIL density, either overall or by subtype.Conclusion: No significant correlation was observed between PD-L1 expression and TIL density in ovarian carcinoma subtypes. The variability in their expression suggests immune microenvironment heterogeneity, supporting the need for separate evaluation of these biomarkers and individualized approaches to immunotherapy. AbstrakLatar Belakang: PD-L1 dan TILs merupakan komponen utama dalam mikrolingkungan tumor yang berperan penting dalam regulasi respons imun terhadap karsinoma ovarium. Hubungan antara keduanya masih jarang dikaji, khususnya pada berbagai subtipe histopatologi.Tujuan: Menilai hubungan antara ekspresi PD-L1 dan densitas TILs pada beberapa subtipe karsinoma ovarium.Metode: Penelitian cross-sectional analitik pada 40 kasus karsinoma ovarium menggunakan pewarnaan imunohistokimia. Ekspresi PD-L1 dan densitas TILs dianalisis pada area intratumoral dan stromal. Uji korelasi Somers’ D digunakan untuk menilai hubungan antar variabel.Hasil: Mayoritas pasien berusia 40–50 tahun dan berada pada stadium klinis I, dengan subtipe terbanyak adalah serous carcinoma. Densitas TILs intratumoral dan stromal sebagian besar tergolong rendah (77,5% dan 72,5%). Ekspresi PD-L1 intratumoral positif ditemukan pada 5% kasus, sedangkan ekspresi PD-L1 stromal tidak ditemukan. Tidak terdapat hubungan yang bermakna antara ekspresi PD-L1 dan densitas TILs, baik secara keseluruhan maupun berdasarkan subtipe.Kesimpulan:Tidak ditemukan korelasi signifikan antara ekspresi PD-L1 dan densitas TILs pada subtipe karsinoma ovarium. Variasi pola ekspresi antar subtipe mencerminkan heterogenitas imun tumor, sehingga diperlukan evaluasi terpisah PD-L1 dan TILs sebagai biomarker serta pendekatan individualisasi dalam terapi imun.
PEMERIKSAAN IMUNOHISTOKIMIA CLAUDIN-4 PADA PREPARAT CELL BLOCK CAIRAN EFUSI PLEURA BERDASARKAN KATEGORI DIAGNOSTIK THE INTERNATIONAL SYSTEM FOR REPORTING SEROUS FLUID CYTOPATHOLOGY: IMMUNOHISTOCHEMICAL EXAMINATION OF CLAUDIN-4 ON CELL BLOCK PREPARATIONS OF PLEURAL EFFUSION FLUIDS BASED ON DIAGNOSTIC CATEGORIES OF THE INTERNATIONAL SYSTEM FOR REPORTING SEROUS FLUID CYTOPATHOLOGY Kuncara, Dede Bisma; Mariedina, Causa Trisna; Betty; Lukito, Joko S; Chrestella, Jessy
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 24 No. 2 (2025): Juli 2025
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v24i2.746

Abstract

Efusi pleura mencerminkan kondisi patologis seperti gangguan paru, pleura, sistemik, hingga keganasan. Pemeriksaan sitologi dan imunohistokimia (IHK) cairan efusi pleura bertujuan untuk menilai keterlibatan pleura terhadap metastasis dan meningkatkan ketepatan diagnosis serta penilaian prognostik. Claudin-4, protein transmembran, diketahui terekspresi secara konsisten pada adenokarsinoma metastatik. Penelitian ini bertujuan mengetahui ekspresi IHK Claudin-4 pada sediaan cell block cairan efusi pleura berdasarkan The International System for Reporting Serous Fluid Cytopathology. Penelitian ini merupakan studi deskriptif analitik dengan pendekatan potong lintang terhadap 49 sampel cairan efusi pleura yang diproses menjadi cell block, kemudian dilakukan pewarnaan Hematoksilin-Eosin dan IHK Claudin-4 di RS Pendidikan Prof. dr. Chairuddin Panusunan Lubis USU. Hasil menunjukkan kelompok usia terbanyak 41–50 tahun (32,65%), laki-laki lebih banyak (55,10%), cairan transudat (57,14%), dan volume efusi 11–20 mL (30,61%). Diagnosis sitologi terbanyak adalah kategori NFM (85,72%) dan MAL (14,28%). Ekspresi Claudin-4 positif ditemukan pada seluruh sampel kategori MAL (7/7) dan negatif pada kategori NFM (42/42). Simpulan: Ekspresi Claudin-4 positif pada semua kasus MAL dan negatif pada NFM, menunjukkan potensi Claudin-4 sebagai penanda diagnostik untuk efusi pleura maligna.
The Intrinsic Value of Family Temple Construction in Kasimbar Sub-District Angriana T Winter; Chalarce Totanan; Rahma Masdar; Muhammad Din; Ni Made Suwitri Parwati; Betty
GoodWill Journal of Economics, Management, and Accounting Vol. 5 No. 2 (2025): October 2025
Publisher : www.amertainstitute.com

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/e0dezj48

Abstract

This research aims to find the interinsic value of the cost of building a family temple. The type of research is ethnographic approach. The data used is primary data collected through observation, interviews and documentation. The results found that the intrinsic value of family temple construction reflects deep spiritual, cultural, and social meanings for Hindus. The family temple not only functions as a place of worship to ancestors and manifestations of Ida Sang Hyang Widhi Wasa, but also a symbol of the strength of identity, identity, and emotional attachment between family members. In addition, the process of building a temple also fosters the spirit of mutual cooperation, togetherness, and sincere devotion to dharma values. Thus, the construction of a family temple is not just a physical activity, but a manifestation of the sacred intention to maintain spiritual harmony in family and community life. Theoretically, the development of science has a significant impact on understanding the meaning of intrinsic values in the construction of family temples. The development of science helps to interpret these values not just as part of tradition, but as a foundation that strengthens the family's cultural and spiritual identity. Thus, a broader understanding of intrinsic values through scientific studies encourages people to build family temples not only as physical structures, but as centers of value, moral and spiritual development that have a long-term impact on the family's cultural and social resilience.
PDKK PENGARUH PEMBERIAN TEH KETUMBAR DAN MADU TERHADAP PERUBAHAN TEKANAN DARAH PADA PENDERITA HIPERTENSI DI DESA CEMPAKA PUTIH: ERUBAHAN TEKANAN DARAH PADA PENDERITA HIPERTENSI Hasanah, Nur; Satria, Beny Maulana; Ismaya, Nurwulan Adi; Puji, Lela Kania Rahsa; Hakim, Amelia Nurul; lestari, R. Tri Rahyuning; Betty; Handayani, Putri Handayani
Jurnal Pengabdian Masyarakat Aufa (JPMA) Vol. 7 No. 1 (2025): Vol. 7 No 1 April 2025
Publisher : Universitas Aufa Royhan Di Kota Padangsidipuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51933/jpma.v7i1.1942

Abstract

Hipertensi merupakan salah satu masalah kesehatan yang banyak dialami masyarakat di Desa Cempaka Putih. Penyakit ini sering disebut sebagai the silent killer karena terjadi tanpa gejala yang jelas dan baru diketahui setelah muncul komplikasi serius. Kurangnya pengetahuan masyarakat tentang upaya pengendalian hipertensi secara alami menjadi perhatian dalam kegiatan pengabdian ini.Kegiatan ini bertujuan untuk meningkatkan pengetahuan dan memberikan alternatif pengobatan nonfarmakologis melalui pemanfaatan ramuan teh ketumbar dan madu murni Nusantara dalam menurunkan tekanan darah masyarakat di Desa Cempaka Putih. Kegiatan dilakukan dengan pendekatan edukasi kesehatan, demonstrasi pembuatan ramuan teh ketumbar madu, serta pemeriksaan tekanan darah sebelum dan sesudah konsumsi ramuan. Sebanyak 32 warga berpartisipasi, terdiri dari 16 orang kelompok intervensi dan 16 orang kelompok kontrol. Kelompok intervensi mengonsumsi teh ketumbar madu setiap pagi selama 14 hari. Sebelum intervensi, rata-rata tekanan darah kelompok intervensi sebesar 158/95 mmHg dan kelompok kontrol 151/89 mmHg. Setelah 14 hari, tekanan darah kelompok intervensi menurun menjadi 139/85 mmHg, sedangkan kelompok kontrol menjadi 141/86 mmHg. Hasil uji paired t-test menunjukkan nilai p-value:0,00 (p < 0,05), menandakan adanya penurunan signifikan pada kelompok intervensi. Kegiatan pengabdian ini berhasil meningkatkan pengetahuan masyarakat dan menunjukkan bahwa konsumsi teh ketumbar dan madu dapat menjadi alternatif upaya pengendalian hipertensi secara alami di Desa Cempaka Putih
Pengaruh Teknologi Society 5.0 Dan Transparansi Informasi Terhadap Akuntabilitas Pelaporan Keuangan Musdalifa; Masdar, Rahma; Din, Muhammad; Betty; Karim, Fikry
Balance : Jurnal Akuntansi dan Manajemen Vol. 4 No. 2 (2025): Agustus 2025
Publisher : Lembaga Riset Ilmiah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59086/jam.v4i2.933

Abstract

Penelitian ini bertujuan untuk menganalisis pengaruh teknologi Society 5.0 dan transparansi informasi terhadap akuntabilitas pelaporan keuangan pada BPJS Kesehatan se-Provinsi Sulawesi Tengah. Pendekatan penelitian yang digunakan adalah kuantitatif asosiatif, dengan responden sebanyak 40 orang yang dipilih melalui teknik purposive sampling. Teknik analisis data menggunakan regresi linier berganda dengan bantuan SPSS. Hasil penelitian menunjukkan bahwa secara simultan, teknologi Society 5.0 dan transparansi informasi berpengaruh signifikan terhadap akuntabilitas pelaporan keuangan. Namun secara parsial, hanya variabel transparansi informasi yang berpengaruh signifikan, sedangkan teknologi Society 5.0 tidak menunjukkan pengaruh signifikan. Koefisien determinasi (Adjusted R²) sebesar 0,513 menunjukkan bahwa kedua variabel independen menjelaskan 51,3% variasi akuntabilitas pelaporan keuangan. Temuan ini menekankan pentingnya penerapan transparansi informasi yang memadai dan keterlibatan teknologi secara optimal dalam mendukung akuntabilitas keuangan di institusi publik.
Risk Management in Reducing Audit Findings: Evidence from Indonesia Local Government Weyha, Tifani Keren Hapuk; Furqan, Andi Chairil; Betty; Anshori, Ma'amun
Quantitative Economics and Management Studies Vol. 6 No. 4 (2025)
Publisher : PT Mattawang Mediatama Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/454RI.qems4076

Abstract

Risk management has become an integral element of entity governance, particularly in the public sector, which continues to face intense scrutiny in an effort to minimize audit findings. This study aims to analyze the impact of risk management implementation on audit findings in Indonesian local governments. Through a quantitative approach and linear regression analysis in STATA-17 programming, data was obtained from local governments in 2021, with a total of 542 observations processed. The results revealed that the implementation of risk management contributed to reducing audit findings, especially those related to non-compliance with satutory regulations, including findings that resulted in local financial losses, potential financial losses, revenue shortfalls, and administrative irregularities. This study provides new insights into the important role of risk management in strengthening governance, improving accountability, and optimizing financial management in local governments. Therefore, this study underscores the importance of integrating risk management into every financial management process within local governments to minimize regulatory non-compliance and to achieve effective, efficient, and accountable financial management.
PENGARUH PEMBERIAN VIRTUAL REALITY TERHADAP SKALA NYERI PASIEN POST APPENDIKTOMI DI RSUD KABUPATEN KARANGANYAR nanang; Betty; Yeni
STETHOSCOPE Vol 6 No 1 (2025): STETHOSCOPE
Publisher : Sekolah Tinggi Ilmu Kesehatan Mitra Husada Karanganyar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Appendectomy is a surgical procedure performed to remove the inflamed appendix caused by appendicitis. Post-appendectomy patients often experience significant pain, which can interfere with their recovery process. This study focuses on the administration of Virtual Reality (VR) therapy to reduce the pain scale in post-appendectomy patients. Postoperative pain management is crucial in patient care to expedite recovery and reduce the risk of complications. The objective of this study was to analyze the effect of VR administration on pain scale in post-appendectomy patients at RSUD Karanganyar. A quantitative pre-experimental design with a One Group Pre-test Post-test approach. The sample consisted of 38 patients who met the inclusion criteria, selected using purposive sampling. Data were collected using the Numeric Rating Scale (NRS) to measure pain intensity before and after VR intervention