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All Journal Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research)
Arsyad, M Aryadi
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Agriculture, Biological Sciences & Forestry Veterinary

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Effect of administration of ajwa date extract on renal histopathological changes in meloxicam induced in rats Abdul Halim, Musdalifah; Arsyad, M Aryadi; Dwi Kesuma Sari; Sartini Natsir; Muhammad Husni Cangara; Yulia Yusrini Djabir
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 7, No 2, JULY 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v7i2.21785

Abstract

Objective: This study aimed to examine the nephroprotector effect of ajwa date extract on the kidneys of white rats induced by meloxicam. Methods: 25 male (Rattus norvegicus) rats weighing 200-300 g were divided into 5 groups (n = 5), namely group 1 healthy control without meloxicam and ajwa date extract, group 2 negative control with meloxicam 30mg/kgBB without ajwa dates, group 4 with ajwa date extract 150mg/kgBW and meloxicam 30mg/kgBW, and group 5 with ajwa date extract 300mg/kgBW and meloxicam 30mg/kgBW. The treatment was given for 14 days, on the 15th day a necropsy was performed to take kidney organs for microscopic evaluation or histipathological examination. Results: Meloxicam at a dose of 30mg/kgBW caused damage to the kidneys with observations of glomerular hemorrhage, tubular necrosis, hydropic degeneration and narrowing of the tubular lumen as well as narrowing of the capsular space with an average degree of damage reaching 75% while ajwa date extract doses of 150 and 300mg/kgBW has a nephroprotector effect against meloxicam induction. Conclusion: Ajwa date extract doses of 150 and 300mg/kgBW had a nephroprotector effect on meloxicam induction.
The Effect of Ajwa Date Fruit Extract (Phoenix Dactylifera L.) Against Liver Damage in White Rats (Rattus Norvegicus) Induced by Meloxicam Fatimah Mappanyompa; Arsyad, M Aryadi; Sari, Dwi Kesuma; Natsir, Sartini; Cangara, Muhammad Husni; Djabir, Yulia Yusrini
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 7, No 1, JANUARY 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v7i1.21788

Abstract

Abstract Objective: This study was aimed to investigate the protective effect of Ajwa date palm extract (Phoenix Dactylifera L.) against liver damage in white rats (Rattus norvegicus) induced by Meloxicam. Methods: The samples used in this study were twenty five male white rats divided into five groups with body weight 200 – 300gr, namely a healthy control group, negative control given Meloxicam 30mg/kgBB, treatment group 1 was given Ajwa date fruit extract 75mg/kgBW and Meloxicam 30mg/kgBW, treatment group 2 was given Ajwa date fruit extract 150mg/kgBW and Meloxicam 30mg/kgBW, and treatment group 3 was given Ajwa date fruit extract 300mg/kgBW and Meloxicam 30mg/BW for 14 days. On the 15th day, the rats were anesthetized for blood tests and euthanized for liver organ observation. Results: The result showed by giving Ajwa date palm extract with higher doses and Meloxicam 30mg/kgBW, resulted a decrease in ALT and AST enzyme levels which were close to normal values ​​in rats. Histological observation showed extensive damage to liver cell tissue, with signs of inflammation, hemorrhage, necrosis, and hydropic degeneration. By giving high doses of Ajwa date palm extract and Meloxicam 30mg/kgBW, gave a view of a decrease degree on liver tissue damage. Conclusion: The extract of Ajwa date palm (Phoenix Dactylifera L.) can provide a protective effect against liver damage in white rats (Rattus Norvegicus) induced by Meloxicam with decreased levels of liver function enzymes which are Alananine Transaminase (ALT) and Aspartate Aminotransferase (AST), along in the changes of liver histopathological view which showed a decrease degree of liver cell tissue damage. Keywords: Ajwa date palm extract; Meloxicam; Liver tissue damage.
Co-Authors Abdul Halim, Musdalifah Cangara, Husni Djabir, Yulia Yusrini Dwi Kesuma Sari Fatimah Mappanyompa Natsir, Sartini Sartini Natsir Yulia Yusrini Djabir