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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Monica, Pristia Widya
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Humanities Computer Science & IT Education Engineering Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences Other

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Reduction of Interleukin-6 after PRP-Exosomes Treatment in A Mouse Model of Androgenetic Alopecia Ellistasari, Endra Yustin; Widhiati, Suci; Julianto, Indah; Rosmarwati, Ervina; Monica, Pristia Widya; Yasmin, Aulia
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5508

Abstract

Purpose: This study aim to determine the role of platelet-rich plasma (PRP) exosomes as anti-inflammatory (IL-6) in a mouse model of androgenetic alopecia. Methodology: There are four group of androgenetic alopecia mice model with no treatment group (control group, K1), group treated with PRP-exosomes (K2), group treated with 5% topical minoxidil (K3) and the last group treated with combination of PRP-exosomes and 5% topical minoxidil (K4). All of the group was evaluated clinically and immunohistochemical examination of IL-6 was performed on the 32nd day. Results: Better hair growth results were obtained in the treatment group compared to the control group. In clinical evaluation, K4 had the best results, followed by K2 and K3. The expression of IL-6 is highest in the K1, followed by K4, K2 and K3 and statistically significant. Applications/Originality/Value: PRP-exosomes can enhance hair growth in androgenetic alopecia mice model. IL-6 expression in the control group is significantly higher than in the treatment group.
Efektivitas Terapi Minoksidil pada Alopesia Androgenetik: Studi in Vivo Monica, Pristia Widya; Kariosentono, Harijono; Widhiati, Suci
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i7.15878

Abstract

Alopesia androgenetik merupakan suatu kondisi genetik disebabkan oleh respons berlebih terhadap hormon androgen yang ditandai dengan berkurangnya ukuran folikel rambut terminal pada kulit kepala secara bertahap. Terapi yang tersedia saat ini untuk mencapai pengobatan yang efektif masih terbatas. Penelitian ini bertujuan untuk mengevaluasi efektivitas terapi minoksidil 5% melalui penilaian densitas folikel rambut pada mencit model alopesia androgenetik. Menggunakan metode mencit diinduksi menggunakan testosteron selama 10 hari, kemudian dibagi menjadi dua kelompok, kelompok pertama merupakan kelompok kontrol tanpa mendapakan perlakuan lanjutan. Kelompok kedua diberikan perlakuan aplikasi topikal minoksidil 5% sebanyak dua kali semprotan sekali sehari hingga hari ke-31. Pada hari ke-32, densitas folikel rambut dievaluasi melalui pemeriksaan histopatologi pewarnaan Hematoksilin & Eosin. Analisis statistik menggunakan uji Mann- Whitney dengan tingkat signifikansi p<0,05. Hasil penelitian menunjukan rerata densitas folikel rambut adalah 24,00 pada kelompok kontrol dan 40,14 pada kelompok perlakuan, dengan nilai p<0,05. Kelompok perlakuan aplikasi topikal minoksidil 5% secara signifikan meningkatkan densitas folikel rambut pada kulit mencit model AAG.
Co-Authors Aulia Yasmin, Aulia Ellistasari, Endra Yustin Indah Julianto, Indah Kariosentono, Harijono Rosmarwati, Ervina Widhiati, Suci