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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Proceeding ISETH (International Summit on Science, Technology, and Humanity) Journal of General-Procedural Dermatology & Venereology Indonesia
Rosmarwati, Ervina
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Computer Science & IT Engineering Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Lucio phenomenon in pregnancy: A histopathology review Fiqnasyani, Siti Efrida; Oktavriana,, Triasari; Rosmarwati, Ervina; Novriana, Dita Eka; Mudigdo, Ambar
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Lucio phenomenon (LP) is a reaction occurring in lepromatous, non-nodular, diffuse leprosypatients who have not received multidrug therapy (MDT). The diagnosis of LP are based on clinical features and supported by histopathological examination. This report was conducted to establish a diagnosis of LP byhistopathological examination, considering that cases of LP in pregnancy are quite rare so that clinicians can be more precise. Case: A 35-year-old pregnant woman complained of extensive ulcers on her hand and legs. Madarosis, saddle nose, and earlobes were found A slit skin smear examination showed a bacterial index of +4 and a morphological index of 20%. A skin biopsy from a leg ulcer with HE staining revealed thinning of the epidermis,foamy macrophages, inflammatory cell infiltrate in the dermis and subcutaneous layers, necrotizing vasculitis with thickening of blood vessel walls, and perivascular lymphohistiocytic infiltrate. Histopathological examination of auricular infiltrate showed basket weave type hyperkeratosis, grenz zone, lymphohistiocytic inflammatory cell infiltrates, foamy and touton cells. Histopathological examination by FF staining showed a heavy M. leprae invasion. Discussion: Histopathological characteristics of LP in this patient found flattened epidermis, subepidermal grenz zone, aggregates and sheets of foamy macrophages admixed with predominantly huge numbers of acid-fast bacilli, foamy macrophages and touton cells. The main microscopic features also found subcutis necrotizing vasculitis. Histopathological examinations are essential to diagnose LP. Conclusion: Histopatholgy of Lucio Phenomenon found grenz zone, inflammatory cell infiltrate and foamy cells. This histopatholgy will support the diagnosis and best treatment for LP patient.
Hand Eczema in Nurses in COVID-19 Treatment Room: Frequency of Handwashing, Hand Sanitizer, Moisturizer, and Duration of Latex Gloves Use Rosmarwati, Ervina; Widhiati, Suci; Novriana, Dita Eka; Rahma, Alfina; Kariosentono, Harijono; Irawanto, Muhammad Eko; Kusumawardani, Arie; Ellistasari, Endra Yustin; Oktavriana, Triasari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 2 (2022): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.2.2022.92-98

Abstract

Background: The COVID-19 pandemic causes health workers to use level 2 and level 3 personal protective equipment. Hand washing and the use of latex gloves are important in limiting the spread of COVID-19, but they can potentially induce hand eczema and skin pH disturbance if used too frequently. Purpose: Determine the correlation between the frequency of handwashing and duration of using hand sanitizer and moisturizer as well as skin pH level on the incidence of hand eczema in nurses in the COVID-19 treatment room at RSUD Dr. Moewardi Surakarta. Methods: This cross-sectional study was conducted in the COVID-19 treatment room at RSUD Dr. Moewardi Surakarta with 90 nurses as subjects. A validated questionnaire carried out the frequency of handwashing, hand sanitizer, moisturizer, duration of using latex gloves, and hand eczema complaints. The subject's pH assessment was conducted after 4-5 hours in the COVID-19 treatment room. Data were analyzed bivariately with a Spearman rank correlation test. Result: There was a significant correlation with the incidence of hand eczema with the frequency of handwashing with soap (r=0.305 and p=0.003) and the duration of using latex gloves (r=0.328 and p=0.002) with a weak category correlation (r=0.200-0.399). The frequency of using hand sanitizer, moisturizer, and skin pH did not correlate with the incidence of hand eczema. Conclusion: Frequency of handwashing and the duration of using latex gloves correlated with the incidence of hand eczema, meanwhile frequency of using hand sanitizer, using moisturizer, and skin pH didn't correlate with the incidence of hand eczema.
Retrospective Study of Decubitus Ulcer in Hospitalized Patients Rosmarwati, Ervina; Mulianto, Nurrachmat
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 1 (2023): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.1.2023.46-51

Abstract

Background: Decubitus ulcer is an area of necrotic tissue due to compression of protrusion because of prolonged immobilization. Decubitus ulcer is complication that often occur due to prolonged bed rest. Decubitus ulcer can interfere with patient's recovery process and prolonged hospital stay.  Purpose: To investigate profile of decubitus ulcer in hospitalized patients in Dr. Moewardi General Hospital Surakarta during 2017- 2020. Methods: This descriptive retrospective study was conducted by using medical record of decubitus ulcers (ICD 10 L89.0, L89.1, L89.2, L89.3) in Dr. Moewardi General Hospital Surakarta during 1st January 2017-31st December 2020. Result: There were 375 decubitus ulcer patients, mostly aged 70 years or more (29.1%) and dominated by women (56%). Patients with decubitus ulcers often hospitalized in the regular ward (75.2%) with the longest length of stay being around 0-10 days (49.6%) and the most common comorbidities was malignancy (20.5%). Systemic antibiotic ceftriaxone was most often given to decubitus ulcer patients (21.6%). Most of the patients with decubitus ulcers had stage 2 decubitus ulcers (53.6%) with a predisposition to the affected area being the sacrum area (33%). The most frequently used therapy for decubitus ulcers was hydrogel dressing (33.9%). Conclusion: Decubitus ulcers are often found in patients over 70 years of age with comorbid malignancies. The most common diagnosis was stage 2 decubitus ulcers, predisposing to the sacral region and the most frequently used therapy was hydrogel dressing with ceftriaxone as a systemic antibiotic.
Reduction of Interleukin-6 after PRP-Exosomes Treatment in A Mouse Model of Androgenetic Alopecia Ellistasari, Endra Yustin; Widhiati, Suci; Julianto, Indah; Rosmarwati, Ervina; Monica, Pristia Widya; Yasmin, Aulia
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5508

Abstract

Purpose: This study aim to determine the role of platelet-rich plasma (PRP) exosomes as anti-inflammatory (IL-6) in a mouse model of androgenetic alopecia. Methodology: There are four group of androgenetic alopecia mice model with no treatment group (control group, K1), group treated with PRP-exosomes (K2), group treated with 5% topical minoxidil (K3) and the last group treated with combination of PRP-exosomes and 5% topical minoxidil (K4). All of the group was evaluated clinically and immunohistochemical examination of IL-6 was performed on the 32nd day. Results: Better hair growth results were obtained in the treatment group compared to the control group. In clinical evaluation, K4 had the best results, followed by K2 and K3. The expression of IL-6 is highest in the K1, followed by K4, K2 and K3 and statistically significant. Applications/Originality/Value: PRP-exosomes can enhance hair growth in androgenetic alopecia mice model. IL-6 expression in the control group is significantly higher than in the treatment group.
Co-Authors Ambar Mudigdo Aulia Yasmin, Aulia Dita Eka Novriana Ellistasari, Endra Yustin Fiqnasyani, Siti Efrida Indah Julianto, Indah Irawanto, Muhammad Eko Kariosentono, Harijono Kusumawardani, Arie Monica, Pristia Widya Nurrachmat Mulianto Oktavriana,, Triasari Rahma, Alfina Triasari Oktavriana Widhiati, Suci