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All Journal Majalah Kesehatan FKUB JOURNAL LA MEDIHEALTICO Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Aplikasi IPTEK Indonesia
Aulia Yasmin, Aulia
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Humanities Computer Science & IT Education Engineering Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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PENGARUH KADAR GLUKOSA TERHADAP EKSPRESI PROTEIN AdhO36 BAKTERI Salmonella Typhi Winarsih, Sri; Sujuti, Hidayat; Yasmin, Aulia
Majalah Kesehatan FKUB Vol 4, No 3 (2017): MAJALAH KESEHATAN FAKULTAS KEDOKTERAN
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (612.515 KB) | DOI: 10.21776/ub.majalahkesehatan.2017.004.03.1

Abstract

Demam tifoid yang disebabkan oleh Salmonella Typhi merupakan salah satu penyakit infeksi terbanyak penyebab rawat inap penderita di Indonesia. Sehingga diperlukan penelitian tentang faktor-faktor yang mempengaruhi patogenesitas dari S.Typhi salah satunya adalah kadar glukosa. S. Typhi diketahui memiliki molekul adhesin pada bagian  outer membrane protein (OMP) dengan berat molekul 36 kDa atau disebut juga AdhO36. Molekul adhesin ini berfungsi sebagai perlekatan bakteri pada sel hospes. Pada penelitian ini ingin diketahui pengaruh kadar glukosa terhadap ekspresi protein AdhO36 OMP S. Typhi. Perlakuan glukosa diberikan pada lima kelompok bakteri yaitu konsentrasi 40 mg/100mL, 80 mg/100mL, 160 mg/100mL, 240 mg/100mL dan 320 mg/100mL. Hasil elektroforesis OMP pada lima kelompok bakteri tersebut menunjukkan peningkatan ketebalan pita protein, yaitu semakin tinggi kadar glukosa akan  semakin tebal protein yang  terekspresi. Ketebalan pita protein OMP 36 kDa dibaca menggunakan program Corel Photo Paint 11. Hasil analisis statistik menunjukkan perbedaan yang tidak bermakna (ANOVA, p = 0,559), namun secara deskriptif terlihat adanya peningkatan ketebalan protein OMP 36 kDa pada perlakuan konsentrasi glukosa yang makin besar. Kesimpulan penelitian ini adalah peningkatan kadar glukosa cenderung akan meningkatkan ekspresi protein AdhO36 S. Typhi. Kata kunci : AdhO36, Kadar Glukosa, OMP, Salmonella Typhi
Sistem Pendeteksi Asap Rokok Dengan Sensor MQ-2 Berbasis Mikrokontroler ESP32 Harahap, Erwin; Dhaifullah, Haris; Badruzzaman, Farid; Suparman, Anan; Suliadi, Suliadi; Yasmin, Aulia
Jurnal Aplikasi IPTEK Indonesia Vol 6, No 1 (2022)
Publisher : Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/4.16457

Abstract

Dalam kehidupan sehari-hari seringkali ditemukan berbagai macam tipe asap di lingkungan sekitar seperti: asap rokok, asap hasil pembakaran sampah, dan asap lainnya. Asap merupakan suatu hal yang dapat membahayakan tubuh ketika terhirup, dan keberadaannya juga dapat menandakan bahwa terdapat suatu barang yang sedang terbakar. Pada paper ini penulis merancang sebuah Sistem Pendeteksi Asap Rokok (SPAR) secara real-time berbasis sensor MQ-2 dan mikrokontroler ESP32. SPAR ditempatkan pada lokasi tertentu yang dapat memonitor suatu wilayah secara keseluruhan. Sensor MQ-2 berfungsi untuk mendeteksi keberadaan asap (diantaranya asap rokok) di wilayah tersebut dalam bentuk sinyal analog. Sinyal ini kemudian diterjemahkan ke dalam kode digital dan dibaca oleh mikrokontroler ESP32. Selanjutnya ESP32 mengirimkan perintah kepada buzzer untuk memberikan respon yang sesuai dengan kode program yang telah dirancang. Buzzer akan memberi respon berupa bunyi alarm, dimana hal ini menunjukkan bahwa telah terdeteksi adanya asap rokok di sekitar wilayah tersebut. Melalui suara alarm ini, pihak yang berwenang dapat segera memberikan respon yang sesuai. Hasil penelitian dan eksperimen telah berhasil membuat alat SPAR dan berfungsi baik dalam mendeteksi asap rokok.
Profile of Shingles Patients in Outpatient Settings Dermatology and Venereology Noviani, Laura; Kariosentono, Harijono; Yasmin, Aulia; Kusumasari, Nila
Journal La Medihealtico Vol. 5 No. 4 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i4.1498

Abstract

Herpes zoster (HZ) is a latent varicella zoster virus (VZV) reactivation has been related to aging and immunocompromised condition that affects the skin and mucosa. It becomes increasingly common. However, studies on the clinical profile of HZ in Indonesia are still lacking. Objective of the study is to describe clinico-epidemiological profiles of HZ in Dr. Moewardi General Hospital Surakarta, Indonesia in the period of January 2018 – December 2022. We conducted a retrospective study using the medical records of patients visiting Dermatovenereology Outpatient Clinic of Dr. Moewardi General Hospital Surakarta from January 2018 to December 2022. 48 subjects included in this study 31 of them are females (65%). The subjects were dominated by those aged >50 years old (n:30; 63%). Herpes zoster mostly occurred at thoracal dermatome (n:22: 46%). Top three comorbidities were hypertension (n:10; 21%) followed by autoimmune diseases (n:9: 18%) and malignancy history (n; 6; 13%). Antiviral drugs (n:33; 69%) and antibiotic ointment (n:33; 69%) were the most therapy. More than 50% of subjects received anticonvulsant gabapentin (n:28; 58%) and one-fourth of subjects received analgesic (n:12; 25%). Herpes Zoster most affects middle adulthood population invo involving thoracal dermatome. Hypertension, autoimmune disease and history of malignancy are the common comorbidity. The main therapy of HZ is antivirus in combination with anticonvulsant and analgesic.
Reduction of Interleukin-6 after PRP-Exosomes Treatment in A Mouse Model of Androgenetic Alopecia Ellistasari, Endra Yustin; Widhiati, Suci; Julianto, Indah; Rosmarwati, Ervina; Monica, Pristia Widya; Yasmin, Aulia
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5508

Abstract

Purpose: This study aim to determine the role of platelet-rich plasma (PRP) exosomes as anti-inflammatory (IL-6) in a mouse model of androgenetic alopecia. Methodology: There are four group of androgenetic alopecia mice model with no treatment group (control group, K1), group treated with PRP-exosomes (K2), group treated with 5% topical minoxidil (K3) and the last group treated with combination of PRP-exosomes and 5% topical minoxidil (K4). All of the group was evaluated clinically and immunohistochemical examination of IL-6 was performed on the 32nd day. Results: Better hair growth results were obtained in the treatment group compared to the control group. In clinical evaluation, K4 had the best results, followed by K2 and K3. The expression of IL-6 is highest in the K1, followed by K4, K2 and K3 and statistically significant. Applications/Originality/Value: PRP-exosomes can enhance hair growth in androgenetic alopecia mice model. IL-6 expression in the control group is significantly higher than in the treatment group.
Co-Authors A.A. Ketut Agung Cahyawan W Badruzzaman, Farid Dhaifullah, Haris Ellistasari, Endra Yustin Erwin Harahap Hidayat Sujuti Indah Julianto, Indah Kariosentono, Harijono Monica, Pristia Widya Nila Kusumasari Noviani, Laura Rosmarwati, Ervina Suliadi Suliadi Suparman, Anan Widhiati, Suci