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All Journal Ahmar Metastasis Health Journal (AMHJ) Jurnal Penelitian Inovatif
Putri, Rd. Natasya Aurellia
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Humanities Dentistry Education Engineering Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Mekanisme Escherichia coli dalam Patogenesis Infeksi Saluran Kemih: Literature Review Nursifa, Anis Fauziah; Hafiz, Mochammad Ikhbar; Amalia, Najwa Syifa; Maulidina, Nayla Fasya; Choironissa, Nazwa Shifa; Salma, Nisrina Nabila; Putri, Rd. Natasya Aurellia; Ringo, Regita Ayu Revalina Siringo; Puspita, Reva Sri; Rosdiani, Rosdiani; Sopiah, Popi
Jurnal Penelitian Inovatif Vol 5 No 2 (2025): JUPIN Mei 2025
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jupin.1480

Abstract

Infeksi Saluran Kemih (ISK) merupakan salah satu infeksi bakteri yang paling umum terjadi dan dapat menyebabkan komplikasi serius apabila tidak ditangani secara tepat. Escherichia coli, khususnya Uropathogenic Escherichia coli (UPEC), merupakan patogen utama penyebab ISK dengan berbagai mekanisme patogenik. Studi ini bertujuan untuk meninjau secara sistematis mekanisme patogenesis E. coli dalam menyebabkan ISK. Metode yang digunakan adalah scoping review terhadap literatur yang dipublikasikan antara tahun 2016 hingga 2025, dengan sumber data dari Google Scholar, ScienceDirect, dan Semantic Scholar. Seleksi dilakukan berdasarkan kriteria PICO: Population (penderita ISK), Intervention (Escherichia coli), Comparison (tidak ada), Outcome (mekanisme patogenesis). Sebanyak tujuh artikel yang relevan berhasil diseleksi dan dianalisis. Hasil kajian menunjukkan bahwa UPEC merupakan penyebab dominan ISK, dengan kemampuan adhesi melalui pili sebagai faktor virulensi utama yang memungkinkan bakteri melekat pada sel epitel saluran kemih. Mekanisme patogenesis melibatkan proses kolonisasi, adhesi, invasi, replikasi, serta aktivasi respons imun dan inflamasi. Kajian ini memberikan kontribusi penting dalam memahami strategi patogenik E. coli, yang dapat mendukung pengembangan pendekatan diagnostik dan terapeutik yang lebih efektif dalam pengelolaan ISK.
Corticosteroids as “God Drugs”: Between Therapeutic Efficacy and Side Effects Oktorra, Elsya Jaisi; Permana, Dicka Trie; Amanda, Revana Putri; Fitriyani, Fitriyani; Puspita, Reva Sri; Nurcholisa, ⁠Siti; Putri, Rd. Natasya Aurellia; Ridwan, Heri
Ahmar Metastasis Health Journal Vol. 5 No. 3 (2025): Ahmar Metastasis Health Journal
Publisher : Yayasan Ahmad Mansyur Nasirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/amhj.v5i3.713

Abstract

Corticosteroids are potent anti-inflammatory and immunosuppressive agents widely used in clinical practice due to their rapid therapeutic effects. Despite their proven efficacy, prolonged and inappropriate use is associated with a wide range of adverse effects affecting multiple organ systems. This systematic review aimed to evaluate the therapeutic benefits of corticosteroids and to summarize their reported side effects based on literature published between 2015 and 2025. A systematic search was conducted using Google Scholar, PubMed, and ScienceDirect with the keywords “corticosteroids,” “benefits,” and “side effects.” Eligible studies were full-text, open-access articles published in English or Indonesian. Eight articles met the inclusion criteria and were analyzed descriptively. The findings indicate that corticosteroids are effective in managing inflammatory conditions such as asthma, autoimmune diseases, atopic dermatitis, nephrotic syndrome, and postoperative inflammation. However, long-term use is associated with metabolic and endocrine disturbances (hyperglycemia and Cushing’s syndrome), musculoskeletal complications (osteoporosis and osteonecrosis), dermatological effects (skin atrophy and irritation), ocular disorders (increased intraocular pressure and glaucoma), and cardiovascular effects. Systemic corticosteroids pose the highest risk of adverse effects, while topical and ocular formulations predominantly cause local reactions but may still lead to serious complications with prolonged use. Children and older adults are particularly vulnerable. In conclusion, corticosteroids remain essential in clinical therapy, but their use must be rational, closely monitored, and supported by patient education to minimize long-term risks.
Co-Authors Amalia, Najwa Syifa Amanda, Revana Putri Choironissa, Nazwa Shifa Fitriyani Fitriyani Hafiz, Mochammad Ikhbar Maulidina, Nayla Fasya Nurcholisa, ⁠Siti Nursifa, Anis Fauziah Oktorra, Elsya Jaisi Permana, Dicka Trie Puspita, Reva Sri Ridwan, Heri Ringo, Regita Ayu Revalina Siringo Rosdiani Rosdiani Salma, Nisrina Nabila Sopiah, Popi