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All Journal Jurnal Kesehatan Ilmiah Indonesia / Indonesian Health Scientific Journal Jurnal Buana Farma
Aliviani, Arvi
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Dampak Mutasi HMPV pada Pasien Kanker : Scoping Review Marsya, Shofi; Aliviani, Arvi; Tiranie, Dian; Vita, Elsa; Nabila, Levina; Aulia, Shera; Sadiyah, Halimah; Ramadhan, Gilang; Hanah, Ray; Aqiqah, Zahra; Sopiah, Popi
Jurnal Kesehatan Ilmiah Aufa Royhan Vol 10 No 1 (2025): Vol. 10 No. 1 Juni 2025
Publisher : Universitas Aufa Royhan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51933/health.v10i1.1919

Abstract

Human Metapneumovirus (HMPV) adalah virus RNA dari keluarga Paramyxoviridae yang menyebabkan infeksi saluran pernapasan dan dapat mengalami mutasi, meningkatkan risiko penyakit serius. Penelitian ini bertujuan untuk menggambarkan dampak mutasi HMPV terhadap keparahan infeksi pada pasien kanker. Metode penelitian menggunakan scoping review dengan sumber data dari Google Scholar, PubMed, dan Semantic Scholar, menggunakan kata kunci mutasi HMPV, kanker, dan dampak. Kriteria inklusi mencakup artikel berbahasa Indonesia dan Inggris, pasien kritis, artikel full-text/open access, serta publikasi tahun 2015–2025 yang relevan dengan topik. Analisis dilakukan menggunakan diagram PRISMA untuk menyeleksi artikel yang sesuai. Hasil penelitian menunjukkan bahwa infeksi HMPV pada pasien kanker dapat memperburuk kondisi akibat penurunan sistem imun yang disebabkan oleh terapi kanker seperti kemoterapi atau transplantasi sel punca. Infeksi ini juga berisiko menimbulkan komplikasi serius, seperti pneumonia dan gagal napas, serta menghambat pengobatan kanker yang sedang berlangsung. Mengingat status imun yang terganggu, pasien kanker lebih rentan terhadap dampak mutasi virus ini. Oleh karena itu, penelitian lebih lanjut diperlukan untuk memahami konsekuensi klinis mutasi HMPV guna mengoptimalkan strategi pencegahan dan penanganan.
ANALISIS EFEK SAMPING JANGKA PANJANG PENGGUNAAN ANTASIDA KALSIUM KARBONAT: NARRATIVE REVIEW Ridwan, Heri; Aliviani, Arvi; Febriyanti, Ine; Nathania, Levina Nabila; Ramadhan, Muhammad Gilang; Ramadani, Nur Oktavia; Maharani, Syifa Anisa
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1568

Abstract

The widespread use of calcium carbonate antacids in self-medication is often considered safe, but excessive consumption and long-term use can cause serious side effects that affect various body systems. This study aims to analyze the long-term side effects of calcium carbonate based on the latest scientific evidence. The method used was a narrative review by selecting relevant articles from PubMed, ScienceDirect, and Google Scholar through inclusion and exclusion criteria, resulting in six main articles for analysis. The results showed that prolonged use of CaCO₃ can cause progressive hypercalcemia, which has the potential to develop into Milk-Alkali Syndrome, characterized by hypercalcemia, metabolic alkalosis, and impaired kidney function. Further complications reported include nephrolithiasis, acute pancreatitis, metabolic disorders, and progressive renal dysfunction. In addition, CaCO₃ is known to interfere with the absorption of various drugs through chelation and changes in gastric pH, thereby potentially reducing the effectiveness of therapy. In conclusion, long-term use of calcium carbonate antacids without adequate monitoring can pose significant health risks, making education and supervision of antacid use essential to prevent toxicity and harmful drug interactions.
Co-Authors Aqiqah, Zahra Aulia, Shera Febriyanti, Ine Gilang Ramadhan Hanah, Ray Maharani, Syifa Anisa Marsya, Shofi Nabila, Levina Nathania, Levina Nabila Ramadani, Nur Oktavia Ramadhan, Muhammad Gilang Ridwan, Heri Sadiyah, Halimah Sopiah, Popi Tiranie, Dian Vita, Elsa