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All Journal MNJ (Malang Neurology Journal) JUKEJ: Jurnal Kesehatan Jompa
Rukmi, Kartika Widya
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Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Abses Paru Pada Pasien Tuberkulosis Dengan Diabetes Melitus Yang Tidak Terkontrol Efiyanti, Christy; Prawiro, Asysyukriati; Syahbunan, Khansa Kiasati Chandra; Rusmajati, Jetty; Rukmi, Kartika Widya; Kemuning, Asri Ragil; Desdiani, Desdiani
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 1 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss1.1471

Abstract

The coexistence of tuberculosis (TB) and diabetes mellitus (DM) increases the risk of severe lung complications such as pulmonary abscess. Aim: This study evaluates the outcomes of such cases, emphasizing the effectiveness of combined therapeutic approaches. Methods: This retrospective study reviewed 121 patients diagnosed with TB and DM treated at a hospital in Depok City between January 2023 and April 2024. The study included four patients with confirmed lung abscesses. Diagnosis was established using clinical and supporting examination analyses. We monitored the patients for up to nine months after initiating treatment. All patients received standard TB and DM therapy along with intravenous antibiotics for two weeks and continued with oral antibiotics for six weeks. Results: Radiological findings consistently showed lung cavities with fluid levels and thick walls. Clinical outcomes demonstrated substantial improvement in all cases, with resolution of abscesses and symptom alleviation. Patients with lung abscesses who received early, combination treatment with antibiotics and medication for TB and DM had positive results. Conclusion: In our study, the administration of antibiotics for eight weeks, alongside simultaneous treatment for TB and DM, led to significant clinical improvement. Further research is warranted to management of lung abscesses in patients with TB and DM and intravenous antibiotics as the first-line approach.
PIMPINELLA PRUATJAN MOLK. AS A POTENTIAL ANTI-DIABETIC NEUROPATHY WITH ANTIOXIDANT MECHANISMS: A REVIEW Dewi, Trisni Untari; Mondiani, Yeni Quinta; Rukmi, Kartika Widya; Munawaroh, Fauziyatul; Rusmajati, Jetty; Batubara, Irmanida
MNJ (Malang Neurology Journal) Vol. 12 No. 2 (2026): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2026.012.02.17

Abstract

Medicinal plant utilization in the clinical management of metabolic disorders, including Diabetes Mellitus (DM) and its associated complications, has gained considerable scientific attention in recent decades. Their perceived tolerability positions them as viable complementary or adjunct options to standard pharmacological regimens. Purwoceng (Pimpinella pruatjan Molk.) is a plant indigenous to Indonesia that demonstrates notably high concentrations of antioxidant constituents. Given that oxidative stress constitutes a fundamental driver in the pathophysiology of DM, it is implicated in the development of complications including diabetic peripheral neuropathy. Objective: To review existing evidence on the potential of purwoceng in reducing blood glucose levels and repairing nerve damage in diabetic neuropathy, including its mechanisms, active compounds, and toxicity profile. Methods: A literature review was conducted using keywords including Pimpinella pruatjan/Molk, Purwoceng, Antioxidant, Diabetes Mellitus, Diabetic Neuropathy, and secondary metabolites. Relevant studies were selected and critically reviewed. Results: Several studies identified secondary metabolites in purwoceng, including phenolics, flavonoids, tannins, coumarins, saponins, terpenes, and steroids. These compounds exhibit antioxidant and anti-inflammatory properties, suggesting potential benefits in reducing hyperglycemia and preventing or repairing nerve damage in diabetic neuropathy. Available evidence also indicates no significant acute toxicity in renal and hepatic organs. Conclusion: Purwoceng exhibits promising potential as an adjunctive therapeutic agent in the management of Diabetes Mellitus and its neuropathic complication, mediated principally through antioxidant and anti-inflammatory mechanisms, with a favorable preliminary safety profile. Rigorous clinical investigations are warranted to substantiate its efficacy and safety in human subjects.
Co-Authors Asri Ragil Kemuning Christy Efiyanti Desdiani, Desdiani Irmanida Batubara Mondiani, Yeni Quinta Munawaroh, Fauziyatul Prawiro, Asysyukriati Rusmajati, Jetty Syahbunan, Khansa Kiasati Chandra Trisni Untari Dewi