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All Journal Jurnal Jamu Indonesia Jurnal Tumbuhan Obat Indonesia Plexus Medical Journal
Munawaroh, Fauziyatul
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Public Health Other

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Efek Asam Klorogenat pada Ekspresi Mrna IL-6 dan CD86 Lobus Frontal Tikus Model Diabetes Mellitus Munawaroh, Fauziyatul; Hanif , Aisyah Amanda; Ragil Kemuning, Asri; Mutmainah, Iffa; Rachmawati, Yenny; Muharam Nurdin, Naufal
Plexus Medical Journal Vol. 3 No. 4 (2024): Agustus
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v3i4.1815

Abstract

Pendahuluan: Diabetes Mellitus (DM) merupakan penyakit kronik dengan berbagai komplikasi, salah satunya yaitu Encephalopati Diabetikum (ED). Hiperglikemia pada DM akan mengakibatkan neuroinflamasi melalui jalur M1 proinflamatorik. Beberapa agen proinflamatori akan meningkat dengan aktifnya jalur ini, seperti IL-6. Neuroglia kemudian teraktivasi dan mengekspresikan CD86 pada membran sel. Asam klorogenat (CGA) merupakan senyawa polyphenol pada kopi  yang  memiliki  efek antiinflamasi.  Tujuan penelitian ini adalah untuk memperjelas efek CGA pada aktivasi mikroglia jalur M1 dengan melihat ekspresi mRNA IL-6 dan CD86 pada lobus frontal tikus dengan model DM. Metode: 24 ekor tikus jantan secara acak dibagi menjadi enam kelompok yaitu :  kontrol,   DM 1,5 bulan dan DM 2 bulan,  dan kelompok dengan pemberian  CGA dengan  tiga  dosis  berbeda  (CGA1,  CGA2,  CGA3).  Jaringan lobus frontal diambil untuk analisa ekspresi mRNA IL-6 dan CD86 menggunakan RT-PCR. Hasil: Ekspresi mRNA IL-6 lobus frontal berbeda signifikan antara kelompok kontrol dengan DM1,5 (p=0.010); kontrol dengan DM2 (p=0.001); kelompok DM2 dengan CGA2 (p=0.028). Ekspresi mRNA CD86 lobus frontal trdapat perbedaan signifikan antara kelompok kontrol dengan semua kelompok DM, baik dengan CGA atau tanpa CGA (p<0.05). Kelompok DM2 berbeda signifikan dengan kelompok CGA2 (p=0.000) dan kelompok CGA3 (p=0,000). Kesimpulan: Ekspresi mRNA penanda jaras proinflamatorik M1 (IL-6 dan CD86) pada neuroinflamasi lobus frontal akibat DM lebih rendah setelah pemberian CGA dengan dosis 25 mg/KgBB.
Correlation between Time Variation of Steam Distillation of Temu Hitam’s Rhizomes (Curcuma aeruginosa) and Antibacterial Activity of Essential Oil Munawaroh, Fauziyatul; Luthfiana, Widya; Suparto, Irma Herawati; Sari, Yessie Widya; Wahyuni, Wulan Tri; Batubara, Irmanida
Jurnal Jamu Indonesia Vol. 8 No. 3 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i3.345

Abstract

Distillation time can affect the extraction of essential oils such as the rhizome of temu hitam (Curcuma aeruginosa) which has been shown to have antibacterial activity. Therefore, this study aims to determine the optimum distillation time to produce temu hitam rhizome oil with the strongest antibacterial activity. The rhizomes of temu hitam were steam distilled with different length of time every 30 minutes for 4 hours to obtain essential oil and determined the compounds contained in them using gas chromatography-mass spectrometry. Antibacterial activity was determined by disc diffusion against Streptococcus mutans, Escherichia coli, and Staphylococcus aureus. The most dominant compounds present in essential oils are eucalyptol (34.89%), epicurzerenone (20.58%), and camphor (16.90%) based on the average peak of the total distillation time. The strongest antibacterial potency was obtained in the first 30 minutes of distillation for S. mutans and E. coli, and in the seventh 30 minutes of distillation for S. aureus.
Ekstrak Akar Purwoceng sebagai neuroprotektan Terhadap Model Stroke pada Tikus: Memori Spasial, Jumlah Sel Piramidal, Ekspresi SOD1 dan SOD2 Munawaroh, Fauziyatul; Efiyanti, Christy; Utami, Putri; Dewi, Trisni; Batubara, Irmanida
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2236

Abstract

Stroke due to cerebral ischemia is one of the leading causes of disability worldwide. Animal models of cerebral ischemia that is often used is Global Cerebral Ischemia (GCI). In GCI, the hippocampus is the most susceptible to neuronal cell death. Complications that occur after ischemia are due to increased oxidative stress. Some compounds in purwoceng are reported to have antioxidant activity which oxidative stress have not been studied in the GCI model stroke. This study aims to examine the effect of purwoceng extract on a stroke model (GCI) as a neuroprotective agent in the prevention of stroke complications that have not been previously studied. 25 rats with a stroke model were given purwoceng root extract with 3 doses (20, 30, and 40mg/kg BW) orally for three days. The mice were then tested for memory with the Morriz Water Maze (MWM) test; then histopathological analysis of pyramidal cells in the hippocampus and the expression of SOD1 and SOD2 genes was analyzed using RT-PCR. The MWM test showed that the memory results at the dose of 20mg/kg BW were better than that of the GCI group (p=0.0384), and the PCR of SOD2 showed improvement at the dose of 20mg/kg BW (p=0.0171). No significant difference in histopathological analysis and SOD1 mRNA expression across group. The administration of purwoceng root extract at a dose of 20 mg/kg BW had the effect of improving memory and SOD2 expression in GCI model rats
Ekstrak Akar Purwoceng sebagai neuroprotektan Terhadap Model Stroke pada Tikus: Memori Spasial, Jumlah Sel Piramidal, Ekspresi SOD1 dan SOD2 Munawaroh, Fauziyatul; Efiyanti, Christy; Utami, Putri; Dewi, Trisni; Batubara, Irmanida
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2236

Abstract

Stroke due to cerebral ischemia is one of the leading causes of disability worldwide. Animal models of cerebral ischemia that is often used is Global Cerebral Ischemia (GCI). In GCI, the hippocampus is the most susceptible to neuronal cell death. Complications that occur after ischemia are due to increased oxidative stress. Some compounds in purwoceng are reported to have antioxidant activity which oxidative stress have not been studied in the GCI model stroke. This study aims to examine the effect of purwoceng extract on a stroke model (GCI) as a neuroprotective agent in the prevention of stroke complications that have not been previously studied. 25 rats with a stroke model were given purwoceng root extract with 3 doses (20, 30, and 40mg/kg BW) orally for three days. The mice were then tested for memory with the Morriz Water Maze (MWM) test; then histopathological analysis of pyramidal cells in the hippocampus and the expression of SOD1 and SOD2 genes was analyzed using RT-PCR. The MWM test showed that the memory results at the dose of 20mg/kg BW were better than that of the GCI group (p=0.0384), and the PCR of SOD2 showed improvement at the dose of 20mg/kg BW (p=0.0171). No significant difference in histopathological analysis and SOD1 mRNA expression across group. The administration of purwoceng root extract at a dose of 20 mg/kg BW had the effect of improving memory and SOD2 expression in GCI model rats
Co-Authors Aisyah Amanda Hanif Asri Ragil Kemuning Christy Efiyanti Dewi, Trisni Iffa Mutmainah Irma Herawati Suparto Irmanida Batubara Luthfiana, Widya Naufal Muharam Nurdin Putri Utami, Putri Rachmawati, Yenny Wulan Tri Wahyuni Yessie Widya Sari