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All Journal Jurnal Biologi Tropis Journal of Pharmaceutical and Sciences.
Nasution , Muhammad Amin
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Kajian Etnofarmasi Tumbuhan Obat di Kawasan Geotermal Ie Seum, Aceh Besar: Eksplorasi Pengetahuan Tradisional dan Potensi Farmakologis. Fakri, Fajar; Isnaini , Nadia; Nasution , Muhammad Amin; Bakri , Tedy Kurniawan; Illian , Didi Nurhadi; Muhni , Akmal; Andry , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.864

Abstract

Indonesia is recognised as one of the world's megadiverse countries, possessing extraordinary biological wealth, including the medicinal plant potential in the geothermal area of Ie Seum, Ie Seum Village, Mesjid Raya Subdistrict, Aceh Besar District. This study aimed to explore and document local communities' traditional knowledge regarding using medicinal plants through an ethnopharmaceutical approach. A descriptive qualitative method was employed, with data collected via semi-structured interviews and participatory observation involving purposively selected informants. The findings identified nine medicinal plant species, with Eupatorium inulifolium and Vitex pinnata demonstrating the highest use value (UV) scores of 0.750 and 0.438, respectively, indicating their dominant usage in traditional healing practices. Leaves were the most frequently utilised plant parts, with standard preparation methods including boiling and pounding. These plants have traditionally been used to treat various health conditions, including fever, wounds, skin infections, and digestive disorders. The findings highlight the richness of traditional knowledge in Ie Seum and its potential as a foundation for developing natural product-based medicines. The extreme environmental conditions of the geothermal area are believed to influence the bioactive metabolite composition of the plants, potentially enhancing their pharmacological properties. This study underscores the importance of preserving local knowledge and encourages further scientific exploration to support the sustainable use of medicinal plants in developing traditional medicines.
Uji Aktivitas Antibakteri Formulasi Sediaan Obat Kumur Ekstrak Etanol Daun Senduduk (Melastoma malabathricum L.) Terhadap Pertumbuhan Streptococcus mutans Ayu , Tri Indah Pagar; Nasution , Haris Munandar; Rahayu, Yayuk Putri; Nasution , Muhammad Amin
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1002

Abstract

Background: Dental caries is a common oral health problem caused by Streptococcus mutans. Antiseptic mouthwash containing natural ingredients like senduduk leaves (Melastoma malabathricum L.) shows potential as an alternative, as it contains antimicrobial compounds (alkaloids, flavonoids, saponins, and tannins). Objective: To determine the antibacterial activity of senduduk leaf ethanol extract mouthwash against S. mutans and evaluate its physical characteristics. Methods: This experimental study included: (1) ethanol extraction of senduduk leaves using 96% ethanol maceration, (2) simplicia characterization and phytochemical screening, (3) formulation of three mouthwash concentrations (2.5%, 5%, 7.5%), (4) preparation evaluation (organoleptic properties, pH, viscosity), and (5) antibacterial activity testing using the well diffusion method. Results: The mouthwash preparation met physical criteria as a light-to-dark brown liquid with pH 6.33-6.43 and viscosity of 4.833-5.726 cps. Antibacterial tests showed dose-dependent effects, with the highest inhibition zone in the 7.5% formula (18.53 mm; strong category). Conclusion: Senduduk leaf extract shows potential as an antibacterial active ingredient in herbal mouthwash against S. mutans in vitro, though further testing (in vivo/clinical trials) is needed to validate therapeutic claims.
Antioxidant and Antibacterial Activity of Ethanol Extract of Butterfly Leaf (Bauhinia Purpurea L.) with Maceration Extraction Method Surendro, Yasmeen Nazhifah Amani; Nasution , Muhammad Amin; Lubis, Minda Sari; Pulungan, Anili Fithri
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7963

Abstract

The butterfly plant (Bauhinia purpurea L.) is a plant widely used in traditional medicine to treat various ailments. The butterfly plant's leaves have medicinal properties. The leaves of butterfly plants contain bioactive chemicals that can be employed as natural antibacterial and antioxidant agents. The purpose of this study was to evaluate the ethanol extract of butterfly leaves' antibacterial and antioxidant properties. Butterfly leaf extract was obtained using a maceration process with 96% ethanol solvent. Antioxidant activity was measured using the DPPH (1,1-diphenyl-2-picryhydrazyl) and FRAP (Ferric Reducing Antioxidant Power) techniques, with ascorbic acid as a comparator. The disc paper diffusion method was used to test the antibacterial activity against Streptococcus mutans bacteria. The DPPH method has an IC50 value of 27.5484 µg/ml with a very strong category, while the FRAP method has an IC50 value of 72.9311 µg/ml with a strong category. Butterfly leaf extract showed antibacterial efficacy against Streptococcus mutans bacteria at all doses, with maximum inhibition seen at an extract concentration of 50% (inhibition zone diameter: 16.3 mm ± 0.81). The study's findings suggest that butterfly leaf extract works well as a natural antibacterial and antioxidant.
Co-Authors Akmal Muhni Ayu , Tri Indah Pagar Bakri , Tedy Kurniawan Fajar Fakri Haris Munandar Nasution Illian , Didi Nurhadi Isnaini , Nadia Lubis, Minda Sari Muhammad Andry Pulungan, Anili Fithri Surendro, Yasmeen Nazhifah Amani Yayuk Putri Rahayu