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Chemometric-empowered spectroscopic techniques in pharmaceutical fields: A bibliometric analysis and updated review Baidillah Zulkifli; Fajar Fakri; Joan Odigie; Loveday Nnabuife; Chinwe C. Isitua; Williams Chiari
Narra X Vol. 1 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i1.80

Undeniable increase in pharmaceutical demand has encouraged researchers to develop analytical techniques to analyze drugs and monitor their effects. Chemometrics enabled simple spectroscopic approaches (such as infrared or UV spectroscopy) to analyze complex samples, including drug formulations, excreted fluids and tissues of living organisms. The aim of this study was to evaluate the research trend of this combinatorial technique utilized for pharmaceutical-related sample analysis using a bibliometric analysis. Bibliometric data of published literature from the Scopus database on March 14, 2023 were retrieved using the keyword combinations of "multivariate", "chemometrics", "pattern recognition", "drug", "pharmaceutical" and "spectroscopy". Network visualization analysis was performed using VOSviewer on the co-occurring keywords and authorships, presenting data such as top cited papers (n=10). The literature review was performed based on the research trend revealed by the clusters that emerged in the network visualization. The analysis revealed that the first paper was published in 1973 (n=1) and a total of 3544 records have been published as of March 14, 2023, comprising original research articles (n=3144, 88.71%) and review articles (n=232, 6.55%). The keyword “chemometrics” with Total Link Strength (TLS) of 826 emerged as the most abundant, followed by “metabolomics” (TLS=388), “Raman spectroscopy” (TLS=280), “metabonomics” (TLS=272), “nuclear magnetic resonance” or “NMR” (TLS=271), and “multivariate analysis” (TLS=254). Network visualization revealed that the research falls into two general categories: (1) drug toxicity and efficacy monitoring and (2) quality control of drug manufacturing. The top cited paper (n=3269) was a review article published in 1999 describing the utility of nuclear magnetic resonance combined with multivariate statistics for metabolite profiling of biological samples. The chemometric-empowered spectroscopy techniques were expected to provide objective measurement during clinical studies and monitoring of therapeutic effects.

Efficacy of acetazolamide and loop diuretics combinatorial therapy in congestive heart failure: A meta-analysis Duta , Teuku F.; Zulfa , Putri O.; Alina, Meulu; Henira, Najlaika; Tsurayya, Ghina; Fakri, Fajar; Acharya, Yogesh
Narra X Vol. 2 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i1.124

Acetazolamide, one of the carbonic anhydrase inhibitors, has been known to improve the efficacy of diuretic therapy in patients with in congestion heart failure. The aim this study was to investigate the effectiveness of acetazolamide when combined with loop diuretics in ameliorating diuresis and natriuresis in congestive heart failure using systematic review and meta-analysis. Randomized controlled trials (RCTs) and cohort studies were searched on PubMed, Scopus, and Embase on March 7, 2023, by using combinations of ‘acetazolamide’, ‘heart failure’ and along with their respective synonyms. The protocol had been registered on PROSPERO (CRD42023409864). The studies must investigate the effect of oral acetazolamide as the add-on to loop diuretic therapy to be included. Successful decongestion, natriuresis, and diuresis were set as the primary outcomes. The quality of the included studies was assessed using the Cochrane risk-of-bias tool for RCTs and Newcastle Ottawa Scale for observational studies. We identified 1176 titles in the initial search, and further reduced to five studies (three RCTs and two cohort studies) after in-depth screening. A total of 625 patients were recruited in the included studies published from 2015 to 2022. Results from meta-analysis revealed that acetazolamide and loop diuretics combination therapy ameliorated natriuresis (n=4; standardized means difference (SMD)=0.65; 95%CI: 0.07–1.24; p=0.03) and diuresis (n=2; SMD=0.29; 95%CI: 0.12–0.46; p=0.0009) when compared to loop diuretics alone. Acetazolamide and loop diuretics combinatorial therapy is efficacious in alleviating congestion in heart failure patients.

Antimicrobial Properties of Medicinal Plants in the Lower Area of Ie Seu-um Geothermal Outflow, Indonesia Fakri, Fajar; Harahap, Saima Putri; Muhni, Akmal; Khairan, Khairan; Hewindati, Yuni Tri; Idroes, Ghazi Mauer
Malacca Pharmaceutics Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i2.44

The lower area of the Ie Seu-um manifestation, located in Ie Seu-um village, Aceh Besar District, harbors several medicinal plants that exhibit potential for the treatment of infectious diseases. This study aims to assess the secondary metabolite content and in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans of medicinal plants inhabiting the geothermal region. Medicinal plants, namely Pluchea indica (L.) Less., Acrostichum aureum L., Acacia mangium L., and Calotropis gigantea (L.) Dryand., were collected within a range of 100-150 meters from the hot springs in the lower area. Methanol extracts of these medicinal plants underwent phytochemical screening and were tested for antimicrobial activity using the Kirby-Bauer disc diffusion method at a concentration of 50%. The results of phytochemical screening demonstrated positive variations in alkaloids, flavonoids, saponins, steroids, triterpenoids, and tannins for each medicinal plant. The antimicrobial activity of the methanol extracts noticeably inhibited the growth of S. aureus compared to E. coli and C. albicans. The largest inhibition zones were observed for the leaf part of A. mangium (12.70 ± 2.30 mm) against S. aureus, the aerial part of A. aureum (11.57 ± 2.01 mm) against E. coli, and the aerial part of P. indica (9.89 ± 1.11 mm) against C. albicans. Based on the research findings, medicinal plants originating from the lower area of the Ie Seu-um manifestation exhibit potential as antimicrobial agents, particularly against gram-positive bacteria.

Pemberdayaan Penerima Manfaat Program Keluarga Harapan (PKH) di Desa Lamglumpang dalam Produksi Sabun Antibakteri Berbahan Ampas Kopi dan Minyak Nilam Fajar Fakri; Didi Nurhadi Illian; Cut Nella Asyifa; Mirdha Iryana; Muhammad Amin Nasution
Jurnal Pengabdian Magister Pendidikan IPA Vol 7 No 4 (2024): Oktober-Desember 2024
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v7i4.9295

Coffee is one of Indonesia's leading commodities, making it the world's largest coffee producer. In Aceh, the culture of drinking coffee has become part of people's daily traditions, especially in Ulee Kareng Sub-district, which is known as one of the centers of coffee bean powder processing. Large amounts of coffee grounds are produced during the coffee processing process, but they are typically not utilized optimally and often end up as waste. We have the potential to process coffee grounds into value-added products like antibacterial soap. Furthermore, patchouli oil from patchouli plants growing in Aceh has strong antibacterial properties, making it an ideal ingredient for combining with coffee grounds in making antibacterial soap. This community service activity aims to empower the beneficiaries of the Family Welfare Program (PKH) in Lamglumpang Village by improving their skills in making antibacterial soap formulated from coffee grounds and patchouli oil. The training provided is in the form of making dish soap products, as well as understanding the economic potential of these ingredients. The activity stages include socialization, technical training, application of simple technology in production, as well as mentoring and evaluation of product results. Results showed high enthusiasm from participants, with active involvement in the training and a desire to continue soap production independently. We expect this program to create new economic opportunities, enhance the economic independence of the Lamglumpang Village community, and lessen their reliance on social assistance. This antibacterial soap innovation also supports waste reduction and sustainable utilization of local resources.

Chemometric-empowered spectroscopic techniques in pharmaceutical fields: A bibliometric analysis and updated review Zulkifli, Baidillah; Fakri, Fajar; Odigie, Joan; Nnabuife, Loveday; Isitua, Chinwe C.; Chiari, Williams
Narra X Vol. 1 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i1.80

Undeniable increase in pharmaceutical demand has encouraged researchers to develop analytical techniques to analyze drugs and monitor their effects. Chemometrics enabled simple spectroscopic approaches (such as infrared or UV spectroscopy) to analyze complex samples, including drug formulations, excreted fluids and tissues of living organisms. The aim of this study was to evaluate the research trend of this combinatorial technique utilized for pharmaceutical-related sample analysis using a bibliometric analysis. Bibliometric data of published literature from the Scopus database on March 14, 2023 were retrieved using the keyword combinations of "multivariate", "chemometrics", "pattern recognition", "drug", "pharmaceutical" and "spectroscopy". Network visualization analysis was performed using VOSviewer on the co-occurring keywords and authorships, presenting data such as top cited papers (n=10). The literature review was performed based on the research trend revealed by the clusters that emerged in the network visualization. The analysis revealed that the first paper was published in 1973 (n=1) and a total of 3544 records have been published as of March 14, 2023, comprising original research articles (n=3144, 88.71%) and review articles (n=232, 6.55%). The keyword “chemometrics” with Total Link Strength (TLS) of 826 emerged as the most abundant, followed by “metabolomics” (TLS=388), “Raman spectroscopy” (TLS=280), “metabonomics” (TLS=272), “nuclear magnetic resonance” or “NMR” (TLS=271), and “multivariate analysis” (TLS=254). Network visualization revealed that the research falls into two general categories: (1) drug toxicity and efficacy monitoring and (2) quality control of drug manufacturing. The top cited paper (n=3269) was a review article published in 1999 describing the utility of nuclear magnetic resonance combined with multivariate statistics for metabolite profiling of biological samples. The chemometric-empowered spectroscopy techniques were expected to provide objective measurement during clinical studies and monitoring of therapeutic effects.

Efficacy of acetazolamide and loop diuretics combinatorial therapy in congestive heart failure: A meta-analysis Duta , Teuku F.; Zulfa , Putri O.; Alina, Meulu; Henira, Najlaika; Tsurayya, Ghina; Fakri, Fajar; Acharya, Yogesh
Narra X Vol. 2 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i1.124

Acetazolamide, one of the carbonic anhydrase inhibitors, has been known to improve the efficacy of diuretic therapy in patients with in congestion heart failure. The aim this study was to investigate the effectiveness of acetazolamide when combined with loop diuretics in ameliorating diuresis and natriuresis in congestive heart failure using systematic review and meta-analysis. Randomized controlled trials (RCTs) and cohort studies were searched on PubMed, Scopus, and Embase on March 7, 2023, by using combinations of ‘acetazolamide’, ‘heart failure’ and along with their respective synonyms. The protocol had been registered on PROSPERO (CRD42023409864). The studies must investigate the effect of oral acetazolamide as the add-on to loop diuretic therapy to be included. Successful decongestion, natriuresis, and diuresis were set as the primary outcomes. The quality of the included studies was assessed using the Cochrane risk-of-bias tool for RCTs and Newcastle Ottawa Scale for observational studies. We identified 1176 titles in the initial search, and further reduced to five studies (three RCTs and two cohort studies) after in-depth screening. A total of 625 patients were recruited in the included studies published from 2015 to 2022. Results from meta-analysis revealed that acetazolamide and loop diuretics combination therapy ameliorated natriuresis (n=4; standardized means difference (SMD): 0.65; 95%CI: 0.07–1.24; p=0.03) and diuresis (n=2; SMD: 0.29; 95%CI: 0.12–0.46; p=0.0009) when compared to loop diuretics alone. Acetazolamide and loop diuretics combinatorial therapy is efficacious in alleviating congestion in heart failure patients.

Pemanfaatan pekarangan rumah untuk budidaya TOGA sebagai upaya meningkatkan kesehatan keluarga Fakri, Fajar; Muhni, Akmal; Asyifa, Cut Nella; Safira, Maya; Ashsiddiqi, Farhan
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 8 No 2 (2025)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v8i2.22874

Kesehatan keluarga merupakan faktor utama dalam meningkatkan kualitas hidup, namun pemanfaatan Tanaman Obat Keluarga (TOGA) di pekarangan rumah masih terbatas akibat kurangnya pengetahuan dan keterampilan, terutama di kalangan ibu rumah tangga. Program pengabdian ini bertujuan untuk meningkatkan peran ibu rumah tangga dalam budidaya dan pemanfaatan TOGA melalui edukasi dan pelatihan di Gampong Keuramat, Kecamatan Kuta Alam, Banda Aceh. Metode yang digunakan meliputi sosialisasi berbasis media leaflet dan presentasi, serta pelatihan praktik budidaya dan pengolahan hasil TOGA menjadi produk bernilai tambah. Evaluasi dilakukan melalui pre-test dan post-test, serta survei kepuasan peserta. Hasil menunjukkan lebih dari 90% peserta mampu mengaplikasikan materi yang diberikan, serta lebih dari 85% menyatakan kepuasan terhadap program pengabdian. Program ini tidak hanya meningkatkan keterampilan ibu rumah tangga dalam pemanfaatan TOGA untuk kesehatan keluarga, tetapi juga membuka peluang ekonomi melalui produksi jamu dan makanan fungsional. Meskipun masih terdapat tantangan dalam keberlanjutan program, hasil ini menunjukkan bahwa edukasi dan pelatihan dapat memberdayakan ibu rumah tangga sebagai agen perubahan dalam meningkatkan kesehatan keluarga dan berpotensi direplikasi di daerah lain.

Kajian Etnofarmasi Tumbuhan Obat di Kawasan Geotermal Ie Seum, Aceh Besar: Eksplorasi Pengetahuan Tradisional dan Potensi Farmakologis. Fakri, Fajar; Isnaini , Nadia; Nasution , Muhammad Amin; Bakri , Tedy Kurniawan; Illian , Didi Nurhadi; Muhni , Akmal; Andry , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.864

Indonesia is recognised as one of the world's megadiverse countries, possessing extraordinary biological wealth, including the medicinal plant potential in the geothermal area of Ie Seum, Ie Seum Village, Mesjid Raya Subdistrict, Aceh Besar District. This study aimed to explore and document local communities' traditional knowledge regarding using medicinal plants through an ethnopharmaceutical approach. A descriptive qualitative method was employed, with data collected via semi-structured interviews and participatory observation involving purposively selected informants. The findings identified nine medicinal plant species, with Eupatorium inulifolium and Vitex pinnata demonstrating the highest use value (UV) scores of 0.750 and 0.438, respectively, indicating their dominant usage in traditional healing practices. Leaves were the most frequently utilised plant parts, with standard preparation methods including boiling and pounding. These plants have traditionally been used to treat various health conditions, including fever, wounds, skin infections, and digestive disorders. The findings highlight the richness of traditional knowledge in Ie Seum and its potential as a foundation for developing natural product-based medicines. The extreme environmental conditions of the geothermal area are believed to influence the bioactive metabolite composition of the plants, potentially enhancing their pharmacological properties. This study underscores the importance of preserving local knowledge and encourages further scientific exploration to support the sustainable use of medicinal plants in developing traditional medicines.

Herbal flavonoids in preserving testicular physiology under oxidative stress: A bibliometric analysis of systematic reviews Zulkifli, Baidillah; Fakri, Fajar; Gholib, Gholib; Akmal, Muslim; Adam, Mulyadi; Sabri, Mustafa; Lubis, Triva Murtina; Zainuddin, Zainuddin; Zulfitri, Zulfitri; Admi, Masda; Syah, Nanda Yulian; Usrina, Nora; Fajri, Fauzan
The International Journal of Tropical Veterinary and Biomedical Research Vol 8, No 2 (2023): Vol. 8 (2) November 2023
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v8i2.36616

Herbal antioxidants have gained attention recently as possible treatments for disorders of male reproductive function linked to oxidative stress because of their ability to neutralize free radicals.The investigation into herbal flavonoids for preserving oxidative stress-impaired testicular physiology has been effectively conducted through the visualization of bibliometric analysis. Bibliometric data of published papers collected from the PubMed and Scopus databases in 2018-2023. Network visualization was performed using VOSviewer software on the set keywords that occur (n=15). The literature review was conducted according to the research trends identified by the clusters that appeared in the network visualization. The result revealed that a total of 266 records have been published based on the specified search set keywords since 2018. Through the analysis of keywords, inclusion and exclusion criteria, and the relevant content of papers, 11 articles were identified as suitable for conducting a literature review. Network visualization revealed that the research falls into two general categories: (1) toxicity to the testicles caused by oxidative stress and (2) prevention of oxidative stress impact on tissue through herbal medicine. Examination of the paper's content revealed that certain antioxidant compounds from plants can stabilize free radicals in the testicles. These antioxidants include vitexin, diosmin, hesperidin, phenolic acids, naphthoquinones, fisetin, pachypodol, sciadopitysin, carvacrol, and morin. However, further research is needed to compare active antioxidant content in different herbal plants and identify optimal concentrations for therapeutic effects.

Pemberdayaan Petani Garam Melalui Inovasi Sabun Cuci Piring Berbasis Garam dan Branding Produk Lokal Prajaputra, Vicky; Vonna, Adinda Gusti; Fakri, Fajar; MC, Ulil Amri; Isnaini, Nadia; Panggabean, Dara Meutia; Rezkina, Cutwan Annura; Putri, Rizka Auriza; Musfira, Rifqi; Nurzima; Arifqi, Muhammad; Azizah, Nurfiah; Jannah, Raudhatul; Shahieza, Najmi Dibya; Firzatullah, Muhammad Nabil
Jurnal Pengabdian Magister Pendidikan IPA Vol 8 No 4 (2025): Oktober-Desember 2025
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v8i4.12832

This community empowerment program aims to enhance the capacity and welfare of Kuala Gigieng salt farmers through the innovation of salt-derived products and the strengthening of product branding. The activities were carried out at the Training Center of Universitas Syiah Kuala and in Gampong Neuheun, Aceh Besar District, using a participatory training approach. The stages included socialization, training on the production of salt-based dishwashing soap, practice in crushing and packaging refined salt, business management assistance, and evaluation through pre-test and post-test. The pre-test results showed that most participants had limited understanding of soap making, branding, and business management (≥50% in the poor category). After the training, significant improvements were recorded: 62.29% of participants demonstrated excellent understanding of soap production, 78.57% understood tools and ingredients, 85.71% understood branding and marketing, and 100% expressed very high interest in the program. The dishwashing soap produced was characterized by good foaming quality, effective cleaning ability, and a fresh aroma from patchouli oil. In addition, raw salt was successfully processed into 250 g packaged refined salt under the brand Merak Bintang Global, which increased its market value by approximately 40% compared to bulk salt. Business management assistance also encouraged the establishment of simple financial records and a clearer organizational structure within the farmer group.

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