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All Journal Medika: Jurnal Ilmiah Kesehatan Thrive Health Science Journal
Iradhatullah, Sri Putriani
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Uji Analgesik Ekstrak Akar Tunjuk Langit (Helminthostachys zeylanica L.) Pada Mencit Putih Jantan (Mus musculus) Fitriana, Yuli; Hendriyani, Irmatika; Wahid, Abdul Rahman; Rasmiwati, Rasmiwati; Iradhatullah, Sri Putriani; Faisal, Muhammad; Nurbaety, Baiq; Sugara, Taufan Hari
Medika: Jurnal Ilmiah Kesehatan Vol 5 No 1 (2025): Medika: Jurnal Ilmiah Kesehatan
Publisher : Universitas Nahdlatul Ulama Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69503/medika.v5i1.991

Abstract

Akar tunjuk langit (Helminthostachys zeylanica L.) merupakan salah satu tanaman yang dapat digunakan sebagai obat tradisional dimana di dalamnya terkandung senyawa-senyawa flavonoid, fenolik dan saponin yang mempunyai aktifitas biologis, diantaranya adalah efek analgetik dengan menghambat sintesis enzim siklooksigenase 2 (COX-2). Penelitian ini betujuan untuk mengetahui efek analgesik dari ekstrak Akar Tunjuk Langit (Helminthostachys zeylanica L.) pada Mencit putih jantan (Mus musculus). Penelitian ini menggunakan metode eksperimental Laboratorium dengan menggunakan 28 ekor Mencit putih jantan yang terbagi menjadi 6 kelompok yaitu kelompok kontrol positif (Asam Mefenamat), kontrol negatif (CMC- Na 0,5%), kontrol base line (minum add libitum) dan kelompok perlakuan ekstrak akar tunjuk langit dengan variasi dosis yaitu 100, 200 dan 300 mg/kgBB secara peroral, setelah 30 menit diberikan rangsangan kimia asam asetat 0,5 ml secara intraperitoneal. Pengujian dilakukan selama 3 hari. Parameter yang diamati adalah geliat mencit tiap 5 menit selama 60 menit. Data yang diperoleh dianalisis secara statistik dengan One- S Kolmogorov-Smirnov test, One Way Anova dan Post Hoc test (LSD) dengan taraf kepercayaan 95%. Hasil skrining fitokimia ekstrak akar tunjuk langit didapat bahwa pada pengujian metabolit sekunder flavonoid, saponin dan fenol menunjukkan hasil positif. Hasil penelitian menunjukkan bahwa persen daya analgetik dosis 100 mg/kgBB (25,77% ± 2,56), dosis 200 mg/kgBB (24,04% ± 0,78), dosis 300 mg/kgBB (29,18% ± 5,71) dan dosis Asam Mefenamat (58,48% ± 3,54). Dari hasil penelitian dapat disimpulkan bahwa ekstrak akar tunjuk langit dosis 300 mg/KgBB merupakan dosis terbaik sebagai analgetik dalam menurunkan nyeri pada mencit yang diinduksi asam asetat dengan nilai 29,18% ± 5,71 proteksi tetapi berbeda signifikan dengan dosis Asam Mefenamat.
Antibacterial Activity Test of Ethanol Extract of Palm Leaves (Catharantus roseus) Against Staphylococcus aureus and Escherichia coli Bacteria Fitriana, Yuli; Iradhatullah, Sri Putriani; Sugara, Taufan Hari; Hendriyani, Irmatika; Nurbaety, Baiq; Faisal, Muhammad
THRIVE Health Science Journal Vol. 2 No. 2 (2025): September
Publisher : Balai Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56566/thrive.v2i2.424

Abstract

Ethanol extract of virgin palm leaves (Catharantus roseus) contains active compounds that have potential as natural antibacterial. This study aims to test the antibacterial activity of the extract against Staphylococcus aureus and Escherichia coli bacteria. The leaves of the tread are extracted using the maceration method with a 70% ethanol solvent. The extraction results showed a yield of 6.1% and the identification of compound content showed the presence of alkaloids, flavonoids, saponins, tannins, and phenols. The antibacterial test was carried out by disc diffusion method using concentrations of 60%, 80%, and 100%. Antibacterial activity was tested by calculating the resulting inhibition zones against both types of bacteria. The results showed that in Staphylococcus aureus bacteria, the concentration of 100% resulted in an inhibition zone of 11.66 mm which was classified as strong. In contrast, in Escherichia coli bacteria, the same concentration resulted in an inhibition zone of 2.66 mm which was in the weak category. This difference in effectiveness is due to the cell wall structure of gram-positive and gram-negative bacteria. The results of this study identified that ethanol extract of virgin leaves has a greater potential for gram-positive bacteria than gram-negative. The ethanol extract of virgin leaves demonstrated antibacterial activity against both Staphylococcus aureus and Escherichia coli, with stronger effects observed against S. aureus.
Co-Authors Baiq Nurbaety Hendriyani, Irmatika Irmatika Hendriyani Muhammad Faisal Rasmiwati, Rasmiwati Taufan Hari Sugara Wahid, Abdul Rahman Yuli Fitriana