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Anti Inflammatory And Anti Bacterial Activity Of Sumbawa Oil Sugara, Taufan Hari; Nurbaety, Baiq
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.8010

Sumbawa oil is a traditional ingredient that known as local wisdom of the island society of Sumbawa. It is believed to treat wounds, sprains, rheumatism, thrush and toothache. This study aims to determine the the effectiveness of anti-inflammatory and antibacterial activity of sumbawa oil products based on the types of raw materials and its phytochemical compounds. There are 3 stages in this research, consists of collecting various trademark of sumbawa oil product, determining type of raw material and analysis of phytochemical compound, followed by pharmacological activity test (Anti-inflammatory and antibacterial). Anti-inflammatory test was performed by observing the decrease of percentage inflammation of 21 white rats in 7 groups of egg white injection treatment. Antibacterial test using TSA method by observing the inhibition zone against S. aureus and E. coli bacteria. The results showed that Sumbawa oil products are known to contain secondary metabolite compounds of saponins, Triterpenoids, steroids and Flavonoids. All samples of Sumbawa oil products showed anti-inflammatory activity based on a decrease in the percentage of inflammation in the white rats leg for 6 hours of observation. Sumbawa oil also shows antibacterial activity in the strong category and has a wide spectrum because it can inhibit the growth of gram positive and negative bacteria each of 11,83-14,67 mm and 10,67-12,33 mm.Â This study concluded that Sumbawa oil was shown to have antiinflamatory and antibacterial activity even though its value was still lower than standard drug.

Anti Inflammatory And Anti Bacterial Activity Of Sumbawa Oil Taufan Hari Sugara; Baiq Nurbaety
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Sumbawa oil is a traditional ingredient that known as local wisdom of the island society of Sumbawa. It is believed to treat wounds, sprains, rheumatism, thrush and toothache. This study aims to determine the the effectiveness of anti-inflammatory and antibacterial activity of sumbawa oil products based on the types of raw materials and its phytochemical compounds. There are 3 stages in this research, consists of collecting various trademark of sumbawa oil product, determining type of raw material and analysis of phytochemical compound, followed by pharmacological activity test (Anti-inflammatory and antibacterial). Anti-inflammatory test was performed by observing the decrease of percentage inflammation of 21 white rats in 7 groups of egg white injection treatment. Antibacterial test using TSA method by observing the inhibition zone against S. aureus and E. coli bacteria. The results showed that Sumbawa oil products are known to contain secondary metabolite compounds of saponins, Triterpenoids, steroids and Flavonoids. All samples of Sumbawa oil products showed anti-inflammatory activity based on a decrease in the percentage of inflammation in the white rats leg for 6 hours of observation. Sumbawa oil also shows antibacterial activity in the strong category and has a wide spectrum because it can inhibit the growth of gram positive and negative bacteria each of 11,83-14,67 mm and 10,67-12,33 mm.Â This study concluded that Sumbawa oil was shown to have antiinflamatory and antibacterial activity even though its value was still lower than standard drug.

SOSIALISASI PEMBERDAYAAN MASYARAKAT DESA GRIYA DALAM PEMANFAATAN DAUN KELOR MENJADI OLAHAN SEDIAAN GUMMY CANDIES (YUPPI) YANG BERNILAI EKONOMIS Yuli Fitriana; Irmatika Hendriyani; Dzun Haryadi Ittiqo; Nur Furqani; Baiq Nurbaety; Abdul Rahman Wahid; Melati Permata Hati; Taufan Hari Sugara
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 7, No 2 (2023): June
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v7i2.15322

ABSTRAKNutrceutical dapat didefinisikan sebagai makanan (bagian dari makanan) yang memberikan manfaat medis atau kesehatan, termasuk pencegahan dan atau pengobatan penyakit. Salah satu bentuk sediaan nutrceutical ialah Soft candy. Tanaman yang sering dijumpai dan cukup tinggi untuk menangkal radikal bebas adalah tanaman daun kelor. Metode yang digunakan dalam pembuatan soft candy dari daun kelor adalah mengekstraksi dengan menggunakan metode maserasi yang akan diambil ekstraknya untuk dijadikan soft candy. Perlakuan uji terhadap soft candy antara lain uji flavonoid, organoleptis, dan fisika. Dalam uji flavanoid potif mengandung flavonoid pada sediaan soft candy. Kata kunci: soft candy; kelor; flavonoid ABSTRACTNutrceutical can be defined as food (part of food) that provides medical or health benefits, including the prevention and or treatment of disease. One of the nutrceutical dosage forms is soft candy. Plants that are often found and are tall enough to ward off free radicals are Moringa leaves. The method used in making soft candy from Moringa leaves is extraction using the maceration method which will be extracted to make soft candy. The test treatment for soft candy includes flavonoid, organoleptic, and physical tests. In the positive flavanoid test it contains flavonoids in soft candy preparations. Keywords: soft candy; moringa; flavonoid

Anti Inflammatory And Anti Bacterial Activity Of Sumbawa Oil Sugara, Taufan Hari; Nurbaety, Baiq
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.8010

Sumbawa oil is a traditional ingredient that known as local wisdom of the island society of Sumbawa. It is believed to treat wounds, sprains, rheumatism, thrush and toothache. This study aims to determine the the effectiveness of anti-inflammatory and antibacterial activity of sumbawa oil products based on the types of raw materials and its phytochemical compounds. There are 3 stages in this research, consists of collecting various trademark of sumbawa oil product, determining type of raw material and analysis of phytochemical compound, followed by pharmacological activity test (Anti-inflammatory and antibacterial). Anti-inflammatory test was performed by observing the decrease of percentage inflammation of 21 white rats in 7 groups of egg white injection treatment. Antibacterial test using TSA method by observing the inhibition zone against S. aureus and E. coli bacteria. The results showed that Sumbawa oil products are known to contain secondary metabolite compounds of saponins, Triterpenoids, steroids and Flavonoids. All samples of Sumbawa oil products showed anti-inflammatory activity based on a decrease in the percentage of inflammation in the white rats leg for 6 hours of observation. Sumbawa oil also shows antibacterial activity in the strong category and has a wide spectrum because it can inhibit the growth of gram positive and negative bacteria each of 11,83-14,67 mm and 10,67-12,33 mm.Â This study concluded that Sumbawa oil was shown to have antiinflamatory and antibacterial activity even though its value was still lower than standard drug.

Edukasi pengelolaan limbah obat dalam rumah tangga di Desa Labuapi Nurbaety, Baiq; Fitriana, Yuli; Ittiqo, Dzun Haryadi; Sugara, Taufan Hari; Furqani, Nur; Nopitasari, Baiq Leny; Ningsih, Risma Widia; Rosdiawati, Rosdiawati
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 4 (2024): December
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i4.27944

AbstrakLimbah medis merupakan limbah yang mengandung bahan atau kandungan yang dapat menginfeksi seseorang atau makhluk hidup di sekitarnya. Pada umumnya, masyarakat belum mengetahui bahwa pengolahan limbah medis dan limbah rumah tangga memiliki perbedaan. Pembuangan obat dan sediaan farmasi lain secara tidak tepat akan menimbulkan hal-hal yang tidak diinginkan seperti obat dijual kembali secara ilegal dan disalahgunakan, terutama jika obat dibuang dalam kemanasan aslinya. Masyarakat di Desa Labuapi masih banyak yang belum memahami tentang cara pembuangan limbah obat rumah tangga dengan baik dan benar. Masyarakat yang menangani obat yang rusak/kadaluwarsa dengan cara dibuang ke tempat sampah rumah tangga dan penyimpanan obat yang tidak terpakai dilakukan hingga mencapai tanggal kadaluwarsa. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk memberikan informasi pengelolaan limbah obat rumah tangga di Desa Labuapi. Peserta yang terlibat dalam pengabdian ini sejumlah 23 orang yang terdiri dari perwakilan ibu rumah tangga, kader dan karang taruna. Metode yang digunakan dalam kegiatan ini adalah metode ceramah, pemberian leaflet, booklet dan metode pre - post test dalam bentuk kuesioner. Subyek pengabdian kepada masyarakat ini adalah masyarakat Desa Labuapi. Berdasarkan hasil pretest dan posttest dari kegiatan tersebut dapat dilihat terjadi peningkatan pengetahuan masyarakat Desa Labuapi tentang pengelolaan limbah obat rumah tangga. Pada saat pretest nilai rata-rata peserta adalah 43,47% yang dalam kategori kurang sedangkan pada saat posttest nilai rata-rata peserta meningkat menjadi 78,69% yang dalam kategori Baik. Hal ini menunjukkan bahwa para peserta dapat menerima edukasi yang diberikan dengan baik. Kata kunci: pengelolaan; limbah obat; rumah tangga; desa labuapi AbstractMedical waste is waste that contains materials or ingredients that can infect a person or living creatures around them. In general, people do not know that the processing of medical waste and household waste is different. Improper disposal of medicines and other pharmaceutical preparations will result in undesirable things such as illegal resale of medicines and misuse, especially if the medicines are thrown away in their original packaging. Many people in Labuapi Village still do not understand how to dispose of household medicinal waste properly and correctly. People handle damaged/expired medicine by throwing it in the household trash and storing unused medicine until it reaches the expiry date. The aim of this community service activity is to provide information on household drug waste management in Labuapi Village. There were 23 participants involved in this service consisting of representatives of housewives, cadres and youth organizations. The methods used in this activity are the lecture method, giving leaflets, booklets and the pre-post test method in the form of a questionnaire. The subjects of this community service are the people of Labuapi Village. Based on the pretest and posttest results from this activity, it can be seen that there has been an increase in the knowledge of the Labuapi Village community regarding household drug waste management. During the pretest the participants' average score was 43.47% which was in the poor category, while during the posttest the participants' average score increased to 78.69% which was in the Good category. This shows that the participants can receive the education provided well. Keywords: management; medicinal waste; household; labuapi village

Implementation of FTIR-Based Fingerprinting, Antioxidant Compounds Profiling by UHPLC-Q-Orbitrap HRMS, and Docking Study COVID-19 Inhibitor of Buas-Buas (Premna serratifolia) Leaf Extract from Pontianak Indonesia Dini Hadiarti; Mahwar Qurbaniah; Ely Setiawan; Taufan Hari Sugara
ALCHEMY Jurnal Penelitian Kimia Vol 21, No 1 (2025): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.21.1.92020.149-161

This research aims to profile the active antioxidant compounds from leaf extracts of Buas-buas (Premna serratifolia) growing in Pontianak of West Kalimantan (Indonesia) through a metabolomics approach and their activity as anti-COVID-19 candidates by molecular docking. In this study, P. serratifolia leaves were macerated and fractionated using solvents with different polarities. The extracts were then tested for antioxidant activity using the DPPH method, determined the total phenolic content (TPC), flavonoids (TFC), and steroids (TSC), and analyzed antioxidant the functional groups and compounds by Fourier Transform Infrared spectroscopy (FTIR) and Ultra High-Performance Chromatography UHPLC-Q-Orbitrap HRMS. The functional groups on antioxidant activity were determined by Principal Component Analysis (PCA) and Partial Least Square (PLS) regression. Based on a metabolomics approach, the PCA and PLS analysis shows that hydroxyl was the most active antioxidant from P. serratifolia leaves. UHPLC-Q-Orbitrap HRMS analysis showed the presence of scopoletin, esculetin, 7-hydroxycoumarine, matairesinol, hymecromone, and hexylresorcinol in the water fraction of P. serratifolia leaves. Molecular docking with 4YE6, 1OG5, and 3NRZ shows that matairesinol had the most potential as an antioxidant. Mataresinol and hexyresorcinol are phenolic compounds that have great potential as a COVID-19 inhibitor based on molecular docking with 5R81, 7CMD, and 6M2N.

Enhanced Methods for Synthesizing Hydroxyxanthone Using Eaton and ZnCl2 Catalyst with Microwave Irradiation Yuanita, Emmy; Eryani, Farica; Septiyana, Maulida; Lestarini, Ima Arum; Dharmayani, Ni Komang Tri; Sugara, Taufan Hari
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.753-758

The methods for synthesizing hydroxyxanthone compounds are continually advancing. Among these, microwave-assisted organic synthesis (MAOS) has emerged as a particularly advantageous technique due to its reduced reaction times, improved yields, and enhanced selectivity. This study reports the efficient synthesis of 3,7 dihydroxyxanthone through the reaction of 2,5-dihydroxybenzoate and resorcinol, using Eaton’s reagent and zinc chloride (ZnCl2) as catalyst under MAOS conditions. The structures of the resulting compounds were analyzed using Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR). The efficiency of the catalytic systems was evaluated based on the product yields. The Eaton reagent catalysis resulted in a 9.38% yield of a red solid, while the ZnCl2-catalyzed reaction produced a significantly higher yield of 23.07%, with the product appearing as an orange solid. These results demonstrate that Zn

ANTIOXIDANT ACTIVITY OF TEGINING GANANG (Senna hirsuta L) LEAF EXTRACT USING DPPH METHOD Hendriyani, Irmatika; Maulida, Meri Kartika; Wahid, Abdul Rahman; Khairi, Widayatul; Sugara, Taufan Hari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1724

Tegining ganang (Senna hirsuta L) is a commodity plants on Lombok Island and is traditionally used to treat minor wounds, severe wounds, and skin infections. This study aimed to evaluate the antibacterial and antioxidant activities of ethanol, ethyl acetate, and n-hexane extracts of Tegining ganang leaves against Staphylococcus aureus and Escherichia coli using the DPPH method. The results showed that the ethyl acetate extract exhibited the highest antibacterial activity. Escherichia coli with an inhibition zone of 8.16 mm. For Staphylococcus aureus, the inhibition zone was 1.16 mm. However, all three extracts demonstrated weak antifungal activity. Phytochemical screening revealed the presence of alkaloids and flavonoids in all the extracts. Additionally, the ethanol and ethyl acetate extracts contained phenolic compounds and tannins, which were absent in the n-hexane extract. In the antioxidant activity assay, the 96% ethanol extract demonstrated excellent antioxidant activity with average absorbance values of 0,496 ± 0,018 at 10 ppm, 0,438 ± 0,008 at 20 ppm, 0,357 ± 0,003 at 30 ppm, and 0,326 ± 0,002 at 40 ppm, resulting in an IC?? value of 16,67 ppm. The ethyl acetate extract had an absorbance of 0,537 ± 0,010 at 10 ppm, 0,487 ± 0,002 at 20 ppm, 0,443 ± 0,011 at 30 ppm, 0,392 ± 0,003 at 40 ppm, and 0,383 ± 0,005 at 50 ppm, with an IC?? of 28,50 ppm ...

Uji Analgesik Ekstrak Akar Tunjuk Langit (Helminthostachys zeylanica L.) Pada Mencit Putih Jantan (Mus musculus) Fitriana, Yuli; Hendriyani, Irmatika; Wahid, Abdul Rahman; Rasmiwati, Rasmiwati; Iradhatullah, Sri Putriani; Faisal, Muhammad; Nurbaety, Baiq; Sugara, Taufan Hari
Medika: Jurnal Ilmiah Kesehatan Vol 5 No 1 (2025): Medika: Jurnal Ilmiah Kesehatan
Publisher : Universitas Nahdlatul Ulama Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69503/medika.v5i1.991

Akar tunjuk langit (Helminthostachys zeylanica L.) merupakan salah satu tanaman yang dapat digunakan sebagai obat tradisional dimana di dalamnya terkandung senyawa-senyawa flavonoid, fenolik dan saponin yang mempunyai aktifitas biologis, diantaranya adalah efek analgetik dengan menghambat sintesis enzim siklooksigenase 2 (COX-2). Penelitian ini betujuan untuk mengetahui efek analgesik dari ekstrak Akar Tunjuk Langit (Helminthostachys zeylanica L.) pada Mencit putih jantan (Mus musculus). Penelitian ini menggunakan metode eksperimental Laboratorium dengan menggunakan 28 ekor Mencit putih jantan yang terbagi menjadi 6 kelompok yaitu kelompok kontrol positif (Asam Mefenamat), kontrol negatif (CMC- Na 0,5%), kontrol base line (minum add libitum) dan kelompok perlakuan ekstrak akar tunjuk langit dengan variasi dosis yaitu 100, 200 dan 300 mg/kgBB secara peroral, setelah 30 menit diberikan rangsangan kimia asam asetat 0,5 ml secara intraperitoneal. Pengujian dilakukan selama 3 hari. Parameter yang diamati adalah geliat mencit tiap 5 menit selama 60 menit. Data yang diperoleh dianalisis secara statistik dengan One- S Kolmogorov-Smirnov test, One Way Anova dan Post Hoc test (LSD) dengan taraf kepercayaan 95%. Hasil skrining fitokimia ekstrak akar tunjuk langit didapat bahwa pada pengujian metabolit sekunder flavonoid, saponin dan fenol menunjukkan hasil positif. Hasil penelitian menunjukkan bahwa persen daya analgetik dosis 100 mg/kgBB (25,77% ± 2,56), dosis 200 mg/kgBB (24,04% ± 0,78), dosis 300 mg/kgBB (29,18% ± 5,71) dan dosis Asam Mefenamat (58,48% ± 3,54). Dari hasil penelitian dapat disimpulkan bahwa ekstrak akar tunjuk langit dosis 300 mg/KgBB merupakan dosis terbaik sebagai analgetik dalam menurunkan nyeri pada mencit yang diinduksi asam asetat dengan nilai 29,18% ± 5,71 proteksi tetapi berbeda signifikan dengan dosis Asam Mefenamat.

Antibacterial Activity Test of Ethanol Extract of Palm Leaves (Catharantus roseus) Against Staphylococcus aureus and Escherichia coli Bacteria Fitriana, Yuli; Iradhatullah, Sri Putriani; Sugara, Taufan Hari; Hendriyani, Irmatika; Nurbaety, Baiq; Faisal, Muhammad
THRIVE Health Science Journal Vol. 2 No. 2 (2025): September
Publisher : Balai Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56566/thrive.v2i2.424

Ethanol extract of virgin palm leaves (Catharantus roseus) contains active compounds that have potential as natural antibacterial. This study aims to test the antibacterial activity of the extract against Staphylococcus aureus and Escherichia coli bacteria. The leaves of the tread are extracted using the maceration method with a 70% ethanol solvent. The extraction results showed a yield of 6.1% and the identification of compound content showed the presence of alkaloids, flavonoids, saponins, tannins, and phenols. The antibacterial test was carried out by disc diffusion method using concentrations of 60%, 80%, and 100%. Antibacterial activity was tested by calculating the resulting inhibition zones against both types of bacteria. The results showed that in Staphylococcus aureus bacteria, the concentration of 100% resulted in an inhibition zone of 11.66 mm which was classified as strong. In contrast, in Escherichia coli bacteria, the same concentration resulted in an inhibition zone of 2.66 mm which was in the weak category. This difference in effectiveness is due to the cell wall structure of gram-positive and gram-negative bacteria. The results of this study identified that ethanol extract of virgin leaves has a greater potential for gram-positive bacteria than gram-negative. The ethanol extract of virgin leaves demonstrated antibacterial activity against both Staphylococcus aureus and Escherichia coli, with stronger effects observed against S. aureus.

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