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All Journal Journal of Food and Pharmaceutical Science Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Journal of Food and Pharmaceutical Sciences
Ryan Radix Rahardhian, Muhammad
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Other

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In Silico Study of Compounds Identified in Curcuma aeruginosa Roxb Rhizome as BRAF V600E Inhibitors in Melanoma Cancer Suharsanti, Ririn; Ryan Radix Rahardhian, Muhammad; Kusmita, Lia
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21589

Abstract

Curcuma aeruginosa Roxb rhizome contains secondary metabolite compounds and plays a role in various activities such as antioxidant, antibacterial, anthelmintic, antiandrogenic, antinociceptive, and anticancer. Anticancer activity that has been reported in Curcuma aeruginosa Roxb rhizome is limited to breast and cervical cancer. The purpose of this study was to explore the potential of Curcuma aeruginosa Roxb rhizome in melanoma cancer through the mechanism of inhibiting the BRAF V600E. The 96% ethanol extract of Curcuma aeruginosa Roxb rhizome was separated to produce n-hexane (HF), ethyl acetate (EAF), and ethanol (EF) fractions. The GC-MS results showed that there were 31 compounds from the three fractions. The docking validation process was carried out on the native ligand N-(3-{[5-(4-chlorophenyl) -1H-pyrrolo [2,3b]pyridin3yl] carbonyl}2,4difluorophenyl) propane-1-sulfonamide. All compounds were prepared as ligands for molecular docking with the BRAF V600E receptor (PDB ID: 3OG7). Docking validation on native ligand showed RMSD 1.03Å. The smallest binding affinity are 4,4a,5,6,7,8-Hexahydronaphthalen-2(3H)-one (-6,89 kcal/mol); 1Cyclohexyl-2-propen-1-one (-6,68 kcal/mol); Cyclooctenone (-6,23 kcal/mol); and vemuravnib is still better as K+ (-11.11 kcal/mol). All three compounds do not bind to key amino acid residues of BRAF V600E such as vemuravenib at GLN A:530, CYS A:532; ASP A:594. These results indicate that further structural development is needed for better activity.
In Silico Study of Compounds Identified in Curcuma aeruginosa Roxb Rhizome as BRAF V600E Inhibitors in Melanoma Cancer Suharsanti, Ririn; Ryan Radix Rahardhian, Muhammad; Kusmita, Lia
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21589

Abstract

Curcuma aeruginosa Roxb rhizome contains secondary metabolite compounds and plays a role in various activities such as antioxidant, antibacterial, anthelmintic, antiandrogenic, antinociceptive, and anticancer. Anticancer activity that has been reported in Curcuma aeruginosa Roxb rhizome is limited to breast and cervical cancer. The purpose of this study was to explore the potential of Curcuma aeruginosa Roxb rhizome in melanoma cancer through the mechanism of inhibiting the BRAF V600E. The 96% ethanol extract of Curcuma aeruginosa Roxb rhizome was separated to produce n-hexane (HF), ethyl acetate (EAF), and ethanol (EF) fractions. The GC-MS results showed that there were 31 compounds from the three fractions. The docking validation process was carried out on the native ligand N-(3-{[5-(4-chlorophenyl) -1H-pyrrolo [2,3b]pyridin3yl] carbonyl}2,4difluorophenyl) propane-1-sulfonamide. All compounds were prepared as ligands for molecular docking with the BRAF V600E receptor (PDB ID: 3OG7). Docking validation on native ligand showed RMSD 1.03Å. The smallest binding affinity are 4,4a,5,6,7,8-Hexahydronaphthalen-2(3H)-one (-6,89 kcal/mol); 1Cyclohexyl-2-propen-1-one (-6,68 kcal/mol); Cyclooctenone (-6,23 kcal/mol); and vemuravnib is still better as K+ (-11.11 kcal/mol). All three compounds do not bind to key amino acid residues of BRAF V600E such as vemuravenib at GLN A:530, CYS A:532; ASP A:594. These results indicate that further structural development is needed for better activity.
Penyuluhan Dan Pelatihan Pembuatan Permen Kopi Colo Kelurahan Colo Kecamatan Dawe Kudus Ryan Radix Rahardhian, Muhammad; Fuad Masduqi, Ahmad; Dian Advistasari, Yustisia; Wahyu Ariani, Lilies
Jurnal Dimas Vol 3 No 1 (2021): Jurnal Pengabdian Kepada Masyarakat
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1190.211 KB) | DOI: 10.53359/dimas.v3i1.22

Abstract

Potensi kopi yang dimiliki Kecamatan Dawe Kudus, pihak Kepala Dinas Kebudayaan dan Pariwisata Kabupaten Kudus berupaya membantu memasarkan produk unggulan dari lereng Gunung Muria. Potensi yang dimiliki Kabupaten Kudus utamanya Desa Colo ini luar biasa. Kopi Muria juga tak kalah kualitasnya dengan kopi di daerah lain. Metode yang digunakan dalam kegiatan ini meliputi ceramah, tanya jawab, dan demonstrasi. Ceramah dan tanya jawab dilakukan pada saat proses pelatihan teori di hari pertama. Metode demonstrasi pembuatan permen kopi colo (KOPICO) dilakukan dengan praktik dilakukan pada hari ke dua. Kegiatan ini melibatkan dosen dengan berbagi tugas sebagai fasilitator, Instruktur sebagai pendemonstrasi, Ibu lurah sebagai perwakilan masyrakatan untuk sambutan, serta ibu-ibu pkk sebagai peserta. Keunggulan pada permen kopi yang diformulasikan ini adalah terdiri dari ekstrak kopi, dan bahan-bahan pendukung lainnya mudah diperoleh, sedangkan keunikannya adalah permen alami ini berbentuk gel dan tidak membutuhkan tambahan apapun sehingga bisa langsung dimakan dan cara pembuatannya mudah. Pengabdian ini juga bertujuan mengangkat manfaat bahan alami kopi sebagai bahan dasar permen yang aman dan sehat. Luaran yang diharapkan dapat dicapai adalah meningkatnya pengetahuan dan keterampilan kader ibu-ibu PKK dan pengusaha kopi dalam membuat permen kopi serta publikasi artikel ilmiah pengabdian di jurnal nasional tidak terakreditasi.
Co-Authors Dian Advistasari, Yustisia Fuad Masduqi, Ahmad Lia Kusmita Ririn Suharsanti, Ririn Wahyu Ariani, Lilies