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Indrajaya, Putra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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Dayak Onion (Eleutherine palmifolia) Extract Reduces MSG-Induced Obesity in Mice Rahmatullah, Aldin Akbar; Ratnaningtyas, Nurrohmah; Rahajeng, Anggreani Desi Ramadhani; Indrajaya, Putra; Firdaus, Ahmad Thoriqul; Hidayat, Rosid; Shaffirudin, Yosfiansya Fernandi; Zahli, Haikal Akmal; Irkhamy, Muhamad Naufal
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.72346

Abstract

This study evaluated the anti-obesity effects of Dayak onion (Eleutherine palmifolia) extract in MSG-induced obese mice. Twenty-five male mice were divided into five groups: negative control (CMC-Na), positive control (MSG, 4 mg/g BW), and three groups receiving MSG plus Dayak onion extract at 30, 60, or 120 mg/kg BW for 52 days. Body weight was measured weekly, and abdominal fat (retroperitoneal, epididymal, peritoneal) was weighed using a digital scale on day 53. One-way ANOVA with Duncan’s post hoc test analyzed differences (p<0.05). MSG increased body weight (40.8 ± 1.1 g) and fat compared to the negative control (31.2 ± 0.5 g). Dayak onion extract dose-dependently reduced body weight (T1: 38.2 ± 0.6 g; T2: 36.0 ± 0.9 g; T3: 32.3 ± 0.6 g) and fat, with the 120 mg/kg dose nearing control levels. Flavonoids and anthraquinones in the extract likely drive these effects, suggesting Dayak onion’s potential as a natural anti-obesity agent. Human studies are needed to confirm these findings.
Amelioration of Cigarette Smoke-Induced Hepatic Injury by Green Tea (Camellia sinensis) Extract: Evidence from SGOT and SGPT Biomarkers in a Murine Model Indrajaya, Putra; Mudawamah, Mudawamah; Kalsum, Umi; Trisakti, Adinda Rizky; Rahmatullah, Aldin Akbar
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.72636

Abstract

This study investigated the hepatoprotective effects of green tea extract (GTE) against cigarette smoke-induced liver damage in mice. Twenty-five male mice (Mus musculus) were divided into five groups: negative control (C-), positive control exposed to cigarette smoke (C+), and three experimental groups exposed to cigarette smoke and treated with different doses of GTE: 20 mg/kg BW (T1), 40 mg/kg BW (T2), and 60 mg/kg BW (T3). Following 36 days of treatment, serum SGOT and SGPT levels were measured as biomarkers of hepatocellular injury. Results showed significant elevation of both enzymes in the C+ group (SGOT: 50.46 ± 2.49 U/L; SGPT: 19.48 ± 1.47 U/L) compared to the C- group (SGOT: 35.10 ± 2.49 U/L; SGPT: 10.22 ± 1.68 U/L), indicating cigarette smoke-induced hepatotoxicity. GTE administration demonstrated dose-dependent hepatoprotection, with the highest dose (T3) showing the most substantial effect (SGOT: 38.26 ± 1.25 U/L; SGPT: 11.01 ± 1.05 U/L). Statistical analysis revealed significant differences between groups (p<0.05). The hepatoprotective mechanisms of GTE likely involve its potent antioxidant properties, enhancement of endogenous antioxidant systems, anti-inflammatory effects, modulation of xenobiotic metabolism, and mitochondrial protection. These findings suggest that green tea extract may serve as a promising natural hepatoprotective agent against cigarette smoke-induced liver injury, with potential applications in preventive healthcare strategies.
Co-Authors Firdaus, Ahmad Thoriqul Hidayat, Rosid Irkhamy, Muhamad Naufal Mudawamah Mudawamah Rahajeng, Anggreani Desi Ramadhani Rahmatullah, Aldin Akbar Ratnaningtyas, Nurrohmah Shaffirudin, Yosfiansya Fernandi Trisakti, Adinda Rizky Umi Kalsum Zahli, Haikal Akmal