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All Journal Media Kedokteran Hewan journal of Basic Medical Veterinary Indonesian Andrology and Biomedical Journal
Ratnaningtyas, Nurrohmah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Veterinary

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Dayak Onion (Eleutherine palmifolia) Extract Reduces MSG-Induced Obesity in Mice Rahmatullah, Aldin Akbar; Ratnaningtyas, Nurrohmah; Rahajeng, Anggreani Desi Ramadhani; Indrajaya, Putra; Firdaus, Ahmad Thoriqul; Hidayat, Rosid; Shaffirudin, Yosfiansya Fernandi; Zahli, Haikal Akmal; Irkhamy, Muhamad Naufal
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.72346

Abstract

This study evaluated the anti-obesity effects of Dayak onion (Eleutherine palmifolia) extract in MSG-induced obese mice. Twenty-five male mice were divided into five groups: negative control (CMC-Na), positive control (MSG, 4 mg/g BW), and three groups receiving MSG plus Dayak onion extract at 30, 60, or 120 mg/kg BW for 52 days. Body weight was measured weekly, and abdominal fat (retroperitoneal, epididymal, peritoneal) was weighed using a digital scale on day 53. One-way ANOVA with Duncan’s post hoc test analyzed differences (p<0.05). MSG increased body weight (40.8 ± 1.1 g) and fat compared to the negative control (31.2 ± 0.5 g). Dayak onion extract dose-dependently reduced body weight (T1: 38.2 ± 0.6 g; T2: 36.0 ± 0.9 g; T3: 32.3 ± 0.6 g) and fat, with the 120 mg/kg dose nearing control levels. Flavonoids and anthraquinones in the extract likely drive these effects, suggesting Dayak onion’s potential as a natural anti-obesity agent. Human studies are needed to confirm these findings.
Ameliorative Effects of Eleutherine palmifolia Extract on Monosodium Glutamate-Induced Reproductive Toxicity: Modulation of Oxidative Stress Markers and Spermatogenesis in a Murine Model Rahmatullah, Aldin Akbar; Ratnaningtyas, Nurrohmah; Mustofa, Imam; Mulyati, Sri; Sugihartuti, Rahmi; susilowati, Suherni; Putri, Cindy Ercha Aulia
Indonesian Andrology and Biomedical Journal Vol. 6 No. 1 (2025): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v6i1.72293

Abstract

Background : Chronic monosodium glutamate (MSG) exposure is linked to testicular toxicity, impacting spermatogenesis and oxidative stress markers. Objective : This study investigated the protective effects of Dayak onion (Eleutherine palmifolia) extract against MSG-induced testicular damage in mice. Methods : Twenty-five male mice (11 weeks, ~20 g) were divided into five groups: negative control (C-, 0.5% CMC-Na), positive control (C+, MSG 4 mg/g BW), and treatment groups (T1, T2, T3) receiving MSG plus Dayak onion extract (30, 60, 120 mg/kg BW, respectively) for 52 days. On day 53, testicular histology and serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels were analyzed. One-way ANOVA and Duncan’s post hoc test assessed differences (p<0.05). Results : Group C+ showed significantly reduced spermatogenic cell counts, elevated MDA, and decreased SOD compared to C-. Group T1 exhibited no significant improvement in spermatogonia and spermatocytes but increased spermatids. Groups T2 and T3 significantly improved spermatogenic cell counts, with T3 showing the closest recovery to C-. MDA levels decreased, and SOD activity increased dose-dependently, with T3 nearing C- levels. Conclusion : Dayak onion extract, particularly at 120 mg/kg BW, mitigates MSG-induced testicular toxicity, preserving spermatogenesis and balancing oxidative stress markers.
Protective Effect of The Extract of Dayak Onions (Eleutherine palmifolia) on Sertoli and Leydig Cell Necrosis in Mice (Mus Musculus) Induced with Monosodium Glutamate Rahmatullah, Aldin Akbar; Ratnaningtyas, Nurrohmah; Sugihartuti, Rahmi; Susilowati, Suherni; Safitri, Erma; Mulyati, Sri
Media Kedokteran Hewan Vol. 35 No. 2 (2024): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v35i2.2024.87-96

Abstract

This study aims to determine the effect of the extract of Dayak onions (Eleutherine palmifolia) on the number of necrotic Sertoli and Leydig cells in mice (Mus musculus) induced with monosodium glutamate (MSG). This study involved 25 male mice aged 11 weeks and weighing approximately 20 g. The mice were divided into five groups, namely C- (0.5% CMC-Na), C+ (4 mg/g BW of MSG and 0.5% CMC-Na), T1 (4 mg/g BW of MSG and 30 mg/kg BW of Dayak onion extract), T2 (4 mg/g BW of MSG and 60 mg/kg of Dayak onion extract), and T3 (4 mg/g BW of MSG and 120 mg/kg BW of Dayak onion extract). All treatments were administered for 52 days. The mice were euthanized on day 53 of the experiment. Their testicles were removed and used to prepare histological specimens with the H&E staining method. The results showed significant differences (p < 0.05) in the number of necrotic Sertoli and Leydig cells between the C+ group and the T1, T2, and T3 groups with gradually decreasing values. The results suggested that the administration of the extract of Dayak onions can prevent Sertoli and Leydig cell necrosis in mice induced with MSG at an optimal dose of 120 mg/kg BW.
Co-Authors Erma Safitri Firdaus, Ahmad Thoriqul Hidayat, Rosid IMAM MUSTOFA Indrajaya, Putra Irkhamy, Muhamad Naufal Putri, Cindy Ercha Aulia Rahajeng, Anggreani Desi Ramadhani Rahmatullah, Aldin Akbar Rahmi Sugihartuti, Rahmi Shaffirudin, Yosfiansya Fernandi Sri Mulyati Suherni Susilowati Zahli, Haikal Akmal