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All Journal International Journal of Applied and Scientific Research (IJASR)
Ajanwachukwu Ogbonna Wilson
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Religion Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Social Sciences

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Evaluation of the Histological Effects of Allium Cepa Administration on the Prostate Histology and Prostate Specific Antigen of Male Albino Rats Induced with Ciprofloxacin Mathew, Uwuigbe; Ohiwerei Wisdom Omogbai; Edebiri Ogbemudia E; Ajanwachukwu Ogbonna Wilson; Oriahoghen E E
International Journal of Applied and Scientific Research Vol. 2 No. 11 (2024): November 2024
Publisher : MultiTech Publisher

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The primary objective of this study is to assess the histological impact of Allium cepa administration on prostate histology and prostate-specific antigen (PSA) levels in male albino rats that were induced with ciprofloxacin. A total of 100 albino rats, each weighing between 150–250g, were used in the experiment. The experimental group was further divided into four subgroups, each containing 10 rats, labeled as Groups A, B, C, D, and E. Group A served as the control, while Group B received only ciprofloxacin. Group C was administered ciprofloxacin along with 100mg of Allium cepa extract, whereas Group D received ciprofloxacin and 200mg of Allium cepa extract. Group E was treated solely with Allium cepa extract. Groups B, C, and D were given 22.86 mg/kg of oral ciprofloxacin (500 mg/tablet), manufactured by Fidson Health Care Ltd. The ciprofloxacin was obtained from a reputable pharmaceutical store in Ekpoma, Edo State, and administered via gavage. The control group was provided with only water and food. The PSA levels in control and test subjects were recorded as Mean ± SEM. For the control group, the PSA level was 0.6250 ± 0.085 ng/ml. The PSA levels for test groups B, C, D, and E were 1.575 ± 0.417 ng/ml, 1.200 ± 0.123 ng/ml, 1.125 ± 0.048 ng/ml, and 3.300 ± 0.835 ng/ml, respectively. Notably, only Group E exhibited a significant increase (P<0.05) in PSA levels when compared to the control group.In conclusion, this study indicates that exposure to ciprofloxacin and Allium cepa at mild or moderate doses can lead to severe histopathological changes in the testis, prostate, and epididymis, with the exception of the brain
Histological Effect of Ultra Violet (UV) Light on the Testis of Albino Wistar Rats Uwuigbe Mathew; Ohiwerei Wisdom Omogbai; Ogbe O Clementina; Ajanwachukwu Ogbonna Wilson; Obeagu E I
International Journal of Applied and Scientific Research Vol. 2 No. 12 (2024): December 2024
Publisher : MultiTech Publisher

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UV light, or ultraviolet light, is a type of radiation that falls between the visible light and X-ray regions of the electromagnetic spectrum. It is a form of electromagnetic radiation emitted by the sun and artificial sources, such as tanning beds and UV lamps. It has a shorter wavelength than visible light, ranging from 100 to 400 nanometers (nm). It is categorized into three types based on their wavelengths: UVA, UVB, and UVC. The aim of this study is to evaluate the histopathological effect of uv light on the testis of male Wistar albino rats. A total of fifty (50) adult Albino Wistar rats of comparable sizes were used for this study. They were divided into four equal groups (A – E) with ten (10) rats each. Group A served as the control and the rats were given distilled water and feed only. In addition to feed and water, Groups B rats were kept under Uv light for 30mins, Group C rats were kept under Uv light for 1hour twice daily, Group D rats were kept under Uv light for 2 hours thrice daily and Group E were kept under Uv light for 4 hours thrice daily. The administration was given daily for 14 days (2 weeks) and the weights of both the test and control animals was monitored before and after administration of Uv light. After the administration, the rats were put under light chloroform anaesthesia and the stomach was obtained. ANOVA was used to analyze the results of the weight and differences was considered significant at p<0.05 level of confidence. All data was expressed in table as mean ± standard deviation (SD). From the results, it was observed that Group B showed mild adenofibroma, Group C exhibited denatured testicular cells, indicating severe damage. Group D had adenocarcinoma and fatty tissue, suggesting potential malignancy and Group E presented fatty tissue. In conclusion, the exposure of testis to uv light cause significant alterations in testis histology
Co-Authors Edebiri Ogbemudia E Mathew, Uwuigbe Obeagu E I Ogbe O Clementina Ohiwerei Wisdom Omogbai Oriahoghen E E Uwuigbe Mathew