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All Journal Jurnal Biologi Tropis Lumbung Farmasi : Jurnal Ilmu Kefarmasian SALUT: Journal of Social and Education
Maulira, Dinda Ayu
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences Other

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Determination of Specific and Non-Specific Parameters of Ethanol Extract of Propolis from Tetragonula sp. Maulira, Dinda Ayu; Suhayatman, Early Windari; Ridwan, Sucilawaty; Wahyuni, Nurul
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8889

Abstract

Propolis, which is produced by Tetragonula sp., has the potential to treat a number of illnesses, including microbial infections, wounds, depression, and cancer. However, in order for propolis to be used as a raw material for traditional medicine, it must be standardized. The goal of this study was to standardize the values of specific and non-specific parameters. Propolis was extracted using the maceration method with 70% ethanol solvent until a thick extract was obtained, and the thick extract was tested for both specific and non-specific parameters. In terms of specific parameters, the obtained extract is a thick yellowish-brown liquid, has a characteristic sour propolis scent, and is sticky. Phytochemical screening also showed that the extract was positive for flavonoids, phenolics, alkaloids, saponins and tannins. Meanwhile, the nonspecific test obtained a drying shrinkage value of 35.059%, moisture content of 33.698%, specific gravity of 1.0082 g/ml, and total ash content of 1.26%. The results of the specific and nonspecific parameter tests have met the established extract requirements. Further quantitative identification of the activity of compounds in propolis is recommended for the development of traditional medicine.
Literature Review : Development of Monoclonal Antibodies Using The Expression System of Nicotiana benthamiana Anugraheni, Audina Filsa Nur; Nuralyza, Imasayu; Maulira, Dinda Ayu; Ramadhani, Aliza Salsabila; Nugrahani, Baiq Dwiyan; Sunarwidhi, Anggit Listyacahyani
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8919

Abstract

Monoclonal antibodies (mAbs) have become a key component in modern biotechnology and healthcare, playing essential roles in the treatment of diseases such as cancer, viral and bacterial infections, asthma, and in diagnostic applications. However, conventional mAb production using mammalian cell systems is costly, time-consuming, and presents scalability limitations. To address these challenges, current technological advances have led to the development of alternative platforms using plant-based expression systems. This review aims to explore the potential and progress in producing monoclonal antibodies through the Nicotiana benthamiana plant-based expression system, which offers several advantages including rapid production, cost efficiency, greater production capacity, and reduced risk of contamination. The method employed in this review is a literature study conducted through database searches (Google Scholar, PubMed, Science Direct, and others) focusing on peer-reviewed articles from 2015 to 2024. The articles were selected and then analyzed thematically was performed to extract relevant data. The results indicate that Nicotiana benthamiana can efficiently produce functional mAbs with glycosylation profiles comparable to mammalian systems. In addition, plant antibodies have also been successfully applied in various therapeutic and diagnostic studies. Further research is needed to ensure the safety and effectiveness of Nicotiana benthamiana plant-based mAb, as well as efforts to develop production scale for wider medical applications.
Pengembangan Formula Sediaan Patch Ekstrak Propolis Tetragonula sp. Menggunakan Metode Simplex Lattice Design Maulira, Dinda Ayu; Pratiwi, Eskarani Tri; Hajrin, Wahida; Ridwan, Sucilawaty
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.35926

Abstract

Propolis mengandung flavonoid yang memiliki aktivitas antiinflamasi pada konsentrasi 5%. Flavonoid memiliki permeabilitas rendah pada kulit, sehingga diformulasikan dalam bentuk patch. Pembuatan patch memerlukan HPMC dan PVP sebagai polimer untuk menjaga kualitas fisik patch. Penelitian ini bertujuan untuk mengoptimasi konsentrasi polimer pada patch dengan kandungan ekstrak propolis. Penelitian dilakukan dengan mengekstraksi propolis menggunakan etanol 70% dengan metode maserasi dan dilanjutkan dengan uji kualitatif flavonoid. Untuk proses optimasi, digunakan metode simplex lattice design (SLD) dengan variabel yang dioptimalkan yaitu konsentrasi HPMC dan PVP. Parameter respon yang dievaluasi yaitu sifat fisik meliputi pH, ketebalan, ketahanan lipat, dan daya serap kelembapan. Formula optimum  dievaluasi sifat fisik seperti sebelumnya dengan tambahan uji organoleptis dan keseragaman bobot. Kemudian, formula optimum diverifikasi menggunakan analisis statistik one sample t-test pada perangkat lunak SPSS versi 25 dengan nilai P > 0,05. Hasil penelitian didapatkan rendemen ekstrak sebesar 43,54% dan positif mengandung flavonoid. Berdasarkan metode SLD diperoleh formula optimum dengan konsentrasi HPMC 6% dan PVP 1%. Patch formula optimum memiliki tekstur yang halus, berwarna jernih kekuningan, dan beraroma khas propolis. Verifikasi formula optimum menunjukkan tidak adanya perbedaan bermakna antara respon percobaan dan respon prediksi dengan nilai pH 4,92±0,015; ketebalan 0,218±0,003 mm; ketahanan lipat 343±2,00 dan daya serap kelembapan 5,26±0,047%. Formula patch optimum yang mengandung HPMC 6% dan PVP 1% menghasilkan karakteristik fisik yang baik dan hasil verifikasi yang menunjukkan kesesuaian antara respon prediksi dan hasil percobaan.
Pancasila Sebagai Jiwa Kepribadian Bangsa  : Relevansinya Bagi Generasi Muda di Era Globalisasi Mutthoimah, Ulfatul; Anugraheni, Audina Filsa Nur; Putri, Baiq Haura Audina Ananta; Pramudya, Muhammad Zaidan; Hawarikatun, Baiq; Kanata, Nur Ramdhani; Maulira, Dinda Ayu
Journal of Social and Education Vol. 2 No. 1 (2025): Journal of Social and Education
Publisher : Lembaga Riset dan Publikasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66909/lrp.salut.v2i1.117

Abstract

Pancasila sebagai dasar negara sekaligus jiwa kepribadian bangsa Indonesia menghadapi tantangan serius di era globalisasi, terutama dalam internalisasi nilai-nilainya oleh generasi muda. Arus globalisasi yang membawa budaya asing, gaya hidup individualistik, serta kemajuan teknologi informasi telah berdampak pada menurunnya pemahaman dan pengamalan nilai-nilai Pancasila. Artikel ini bertujuan untuk menganalisis tingkat pemahaman, sikap, serta relevansi Pancasila bagi generasi muda. Metode penelitian dilakukan melalui studi literatur dengan teknik analisis isi yang mengkaji secara mendalam tema utama, kecenderungan berpikir, serta temuan penting dari literatur. Hasil kajian menunjukkan bahwa meskipun sebagian besar generasi muda menyadari pentingnya Pancasila, masih banyak yang belum menerapkannya secara konsisten dalam kehidupan sehari-hari. Oleh karena itu, dibutuhkan strategi edukatif yang adaptif seperti pendidikan karakter berbasis nilai Pancasila, pemanfaatan media digital, serta peran aktif keluarga, institusi pendidikan, dan masyarakat. Penanaman nilai Pancasila sejak dini menjadi langkah strategis untuk memperkuat identitas nasional dan ketahanan ideologi bangsa di tengah derasnya pengaruh globalisasi.
Co-Authors Anugraheni, Audina Filsa Nur Hajrin, Wahida Hawarikatun, Baiq Kanata, Nur Ramdhani Mutthoimah, Ulfatul Nugrahani, Baiq Dwiyan Nuralyza, Imasayu NURUL WAHYUNI Pramudya, Muhammad Zaidan Pratiwi, Eskarani Tri Putri, Baiq Haura Audina Ananta Ramadhani, Aliza Salsabila Ridwan, Sucilawaty Suhayatman, Early Windari Sunarwidhi, Anggit Listyacahyani