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Putri, Ayu Sekarani Damana
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Medicine & Pharmacology Nursing Public Health

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Comparison of Neutrophile-to-Lymphocyte Ratio Between Dengue Haemorrhagic Fever and Dengue Shock Syndrome in Pediatric Patients at Anutapura Hospital Amri, Imtihanah; Rahma, Rahma; Hutasoit, Gina Andyka; Putri, Ayu Sekarani Damana; Harun, Haerani; Rasyid, Riyadh
Journal of Health and Nutrition Research Vol. 4 No. 1 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i1.360

Abstract

Dengue Hemorrhagic Fever (DHF) is an acute viral infectious disease that attacks the body. DHF is divided into 4 grades (I, II, III, IV), in which degrees 3 and 4 are also known as Dengue Shock Syndrome (DSS). When the disease severity is detected too late, it can be fatal. Therefore, a predictor or inflammatory marker is needed to detect and predict this. In this study, the inflammatory marker assessed is the NLR value. This study compares the neutrophil-lymphocyte ratio and the incidence of Dengue Hemorrhagic Fever and Dengue Shock Syndrome in pediatric patients at the Anutapura Regional Hospital, Central Sulawesi Province. This study uses an observational analytical method with a cross-sectional design using secondary data from medical records at the Anutapura Regional Hospital, Palu, in 2021-2023. The sample included is patients with a diagnosis of DHF, totaling 100 samples. The sampling technique used is random sampling. Based on the Mann-Whitney test, a significant difference (p = 0.001) was found in the NLR value between DHF and DSS. The mean NLR in DHF was lower (1.28 (±0.98 SD)) than in DSS (2.07 (±1.59 SD)). There was no significant relationship between age (p=0.217) and gender (p=0.597) in the DHF and DSS groups. It is then concluded that there is a significant difference in NLR values between DHF and DSS, where NLR values are lower in DHF and higher in DSS.
Evaluation of C-Reactive Protein, Neutrophil-To-Lymphocyte Ratio, and Absolute Neutrophil Count as Simple Diagnostic Markers for Spontaneous Bacterial Peritonitis Putri, Ayu Sekarani Damana; Supriono, Supriono; Tonowidjojo, Vera Diana; Fitriani, Junjun; Utama, Gede Nanda; Muthmainah, Andi Alfia; Asrinawati, Andi Nur
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.497

Abstract

Spontaneous bacterial peritonitis (SBP) is a serious complication of liver cirrhosis with high morbidity and mortality. Early diagnosis is crucial; however, ascitic fluid analysis is invasive and often yields a low culture positivity rate. This study aimed to evaluate the diagnostic performance of C-reactive protein (CRP), absolute neutrophil count (ANC), and neutrophil-to-lymphocyte ratio (NLR) as non-invasive markers for the early detection of SBP. A prospective observational study was conducted on 90 liver cirrhosis patients with ascites undergoing diagnostic paracentesis at Saiful Anwar Hospital, Indonesia. CRP, ANC, and NLR levels were compared between the SBP and non-SBP groups. Receiver operating characteristic (ROC) curves were used to assess diagnostic accuracy, and logistic regression identified independent predictors. NLR and ANC levels were significantly higher in SBP patients (p = 0.004 and p = 0.033, respectively), while the difference in CRP levels was not statistically significant (p = 0.372). NLR showed the best performance (sensitivity 81.8%, specificity 68.2%) at a cut-off of 6.8 and was independently associated with SBP (OR = 11.09, p = 0.019). ANC had similar sensitivity but lower specificity, while CRP demonstrated the weakest predictive value. In conclusion, NLR and ANC are emerging as promising, simple, and cost-effective non-invasive biomarkers for the early screening of SBP in cirrhotic patients, particularly in settings where paracentesis is not readily available. NLR, in particular, holds significant diagnostic value. Conversely, CRP may be less reliable in this patient population. Larger multicenter studies are needed to validate these findings
Co-Authors Asrinawati, Andi Nur Fitriani, Junjun Gina Andyka Hutasoit Haerani harun Imtihanah Amri Muthmainah, Andi Alfia Rahma Rahma Rasyid, Riyadh Supriono Supriono Tonowidjojo, Vera Diana Utama, Gede Nanda