Pebriaini, Prisma Andita
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Immune response in IGF-1 and growth parameters among infected children Ardianah, Eva; Widjaja, Nur Aisiyah; Indriani, Diah; Melaniani, Soenarnatalina; Kuntoro; Wibowo, Arief; Notobroto, Hari Basuki; Purnomo, Windhu; Indawati, Rachmah; Saputro, Sigit Ari; Santoso, Febrina Mustika; Puspitasari, Ria; Pebriaini, Prisma Andita; Nurfidaus, Yasmine; Irawan, Roedi; Hidayat, Boerhan; Hidayati, Siti Nurul; Hanindita, Meta Herdiana
BKM Public Health and Community Medicine Vol 41 No 08 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v41i08.18379

Abstract

Purpose: Infections in children can affect weight gain and linear growth by influencing metabolism and nutrition. Chronic inflammation results in growth failure mediated by pro-inflammatory cytokines and poor nutritional intake, which affects the GH/IGF-1 axis. This study aimed to investigate the impact of the inflammatory response on children's anthropometry, particularly HAZ, and the role of IGF-1. Methods: An observational study with a cross-sectional design was conducted from September 2021 to July 2022. The study involved children diagnosed with infections. The subjects had undergone a physical and laboratory investigation, which included a thorax photo, urine culture, Mantoux test, and complete blood test in a hospital setting. A complete medical history was obtained from the pediatrician. Results: The prevalence of undernutrition was 37.33%; the prevalence of underweight/severely underweight, stunted/severely stunted, and wasted/severely wasted was 25.33%, 30.66%, and 14.67% respectively. Stunted/severely stunted was more prevalent in subjects under 2 years old, compared to subjects more than 2 years old (22/41 vs. 7/34, p=0.014). SEM analysis revealed that the inflammatory response affected IGF-1 levels (r=0.850, p=0.000), while IGF-1 affected body composition (r=0.245, p=0.025), and then affected HAZ (r=1.000, p=0.000). The effect of IGF-1 on HAZ appears to be indirect, acting through body composition. Parental height has a weak, albeit significant, effect on body composition (r=0.101, p=0.025) and HAZ (r=0.192, p=0.040). Univariate analysis revealed strong correlations between IL-6 and IL-10 and IGF-1 (r=0.870, p=0.000 and 0.876, p=0.000, respectively). In contrast, parental height showed a correlation with HAZ/LAZ (r=0.319, p=0.000). Maternal height was correlated positively with WAZ (r=0.320, p=0.044). Conclusion: The prevalence of stunting among children under two years of age indicates that early childhood constitutes a critical period for intervention in growth and development. Inflammatory response has been demonstrated to influence IGF-1 levels in children. The role of IGF-1 on HAZ was mediated by body composition.
The effect of e-waste in urban health: a systematic review Pebriaini, Prisma Andita; Kurnia, Galuh Mega; Prasasti, Corie Indria
BKM Public Health and Community Medicine Vol 41 No 05 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v41i05.20058

Abstract

Purpose: E-waste is among the most rapidly increasing types of waste worldwide. This paper aims to systematise the existing literature and explore future research prospects on the effect of e-waste on urban health. Methods: This systematic review follows the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. This literature search utilized articles available in the ScienceDirect, PubMed, and Google Scholar databases, published within the last ten years (2014-2024), to explore the relationship between e-waste and urban health. Results: E-Waste poses serious environmental and health risks, especially in areas with weak regulations and poor waste management. Exposure to hazardous substances through air, soil, and water, such as lead, mercury, and polycyclic aromatic hydrocarbons (PAHs), can lead to respiratory, cardiovascular, and neurodevelopmental issues. Informal recycling worsens these risks, particularly for workers and nearby communities. Weak enforcement, economic barriers, and low public awareness further exacerbate the problem. Effective mitigation includes extended producer responsibility (EPR), formal recycling systems, and a circular economy. Urgent action is needed through stronger policies, enforcement, and awareness; future research should focus on developing sustainable e-waste solutions. Conclusion: Our findings underscore the urgent need for integrated e-waste management policies and practices to safeguard urban public health and mitigate the adverse effects of e-waste exposure. This review lays the groundwork for future research aimed at understanding and addressing the complex health challenges posed by e-waste in urban environments.