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All Journal Media Kedokteran Hewan Indonesian Andrology and Biomedical Journal
Putri, Cindy Ercha Aulia
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Health Professions Medicine & Pharmacology Veterinary

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Ameliorative Effects of Eleutherine palmifolia Extract on Monosodium Glutamate-Induced Reproductive Toxicity: Modulation of Oxidative Stress Markers and Spermatogenesis in a Murine Model Rahmatullah, Aldin Akbar; Ratnaningtyas, Nurrohmah; Mustofa, Imam; Mulyati, Sri; Sugihartuti, Rahmi; susilowati, Suherni; Putri, Cindy Ercha Aulia
Indonesian Andrology and Biomedical Journal Vol. 6 No. 1 (2025): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v6i1.72293

Abstract

Background : Chronic monosodium glutamate (MSG) exposure is linked to testicular toxicity, impacting spermatogenesis and oxidative stress markers. Objective : This study investigated the protective effects of Dayak onion (Eleutherine palmifolia) extract against MSG-induced testicular damage in mice. Methods : Twenty-five male mice (11 weeks, ~20 g) were divided into five groups: negative control (C-, 0.5% CMC-Na), positive control (C+, MSG 4 mg/g BW), and treatment groups (T1, T2, T3) receiving MSG plus Dayak onion extract (30, 60, 120 mg/kg BW, respectively) for 52 days. On day 53, testicular histology and serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels were analyzed. One-way ANOVA and Duncan’s post hoc test assessed differences (p<0.05). Results : Group C+ showed significantly reduced spermatogenic cell counts, elevated MDA, and decreased SOD compared to C-. Group T1 exhibited no significant improvement in spermatogonia and spermatocytes but increased spermatids. Groups T2 and T3 significantly improved spermatogenic cell counts, with T3 showing the closest recovery to C-. MDA levels decreased, and SOD activity increased dose-dependently, with T3 nearing C- levels. Conclusion : Dayak onion extract, particularly at 120 mg/kg BW, mitigates MSG-induced testicular toxicity, preserving spermatogenesis and balancing oxidative stress markers.
Surgical Management of Comminuted Distal Femoral Fracture Using Intramedullary Pin in a Cat Putri, Cindy Ercha Aulia; Rahmatullah, Aldin Akbar; Afandi, Mohammad Auzaie; Halim, Muhammad Al-Syafiq bin Abdul
Media Kedokteran Hewan Vol. 36 No. 3 (2025): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v36i3.2025.329-341

Abstract

A 3-year-old male domestic short-haired cat, weighing 3.8 kg, was presented with lameness, swelling in the left hind limb groin area, and pain upon palpation. Radiographic examination confirmed a comminuted fracture in the diaphysis of the left femur. This case report aims to document the diagnostic approach and surgical management using an intramedullary pin technique. Surgical intervention was performed to restore the anatomical alignment of the fracture fragments. The procedure involved open reduction and internal fixation using an intramedullary pin. Post-operative medication included tramadol (1 mg/kg BW) for analgesia, ceftriaxone (25 mg/kg BW) as antibiotic therapy, and dexamethasone (2 mg/kg BW) for anti-inflammatory effects. Femoral fractures account for 20-26% of fractures in cats, with various treatment options available including pins and wires, Rush pins, threaded intramedullary pins, interlocking pins, clamp rod internal fixators, and plate-rod systems. The intramedullary pin technique was selected for this case due to its suitability for comminuted diaphyseal fractures. This case highlights the efficacy of intramedullary pin fixation as a viable treatment option for comminuted femoral fractures in cats when appropriate surgical technique and post-operative care are implemented.
Co-Authors Afandi, Mohammad Auzaie Halim, Muhammad Al-Syafiq bin Abdul IMAM MUSTOFA Rahmatullah, Aldin Akbar Rahmi Sugihartuti, Rahmi Ratnaningtyas, Nurrohmah Sri Mulyati Suherni Susilowati