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All Journal MEDISAINS JOURNAL OF PHILANTHROPY: The Journal of Community Service
Susanti , Dwi
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Education Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Edukasi Kebiasaan Cuci Tangan pada Anak Pra Sekolah Sebagai Upaya Menurunkan Kejadian Diare di TK ABBA Sunan Gunung Jati Dias Utami , Khristina; Susanti , Dwi; Lutfiyati , Afi; Ferianto
JOURNAL OF PHILANTHROPY: The Journal of Community Service Vol. 1 No. 1 (2023): Journal of Philanthropy, Januari 2023
Publisher : Samodra Ilmu: Lembaga Penelitian, Penerbitan, dan Jurnal Ilmiah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58353/jop.v1i1.74

Abstract

Diarrhea is the second cause of childhood mortality after pneumonia. Globally, diarrhea affects 525.000 (0,030%) children, moreover it has impacted almost 1,7 billion yearly (WHO, 2017). The prevalence in Indonesia has reached to 182,3 (6,2%) among 5-14 years old. In Daerah Istimewa Yogyakarta, the diarrheal disease has always been among the 10 biggest pediatric disease, especially in preschool students are account for 8,47%. The high numbers of diarrheal diseases caused by several factors, one of them is a lack of awareness in wash hand using soap. Educational activity for diarrheal disease and wash hands using soap was conducted in TK Islam Sunan Gunung Jati Kasihan Bantul. The result from this questionnaire shows the majority of students in 6 years old are 59,7%, female students was noted in 57,9%, students that are diarrhea-free in the past 3 months are 87,7%, and students that always wash their hands are 63,2%. This activity used a video as a learning media with 6 steps to wash your hand from WHO, along with the demonstration to wash hands with soap. The result of this education is the students able to answer several questions after the activity. It approves that education use video and hand-wash demonstrations with soap, improves the students’ awareness to prevent diarrhea in children.
Protective effects of black garlic extract on sperm quality and liver histopathology following cigarette smoke exposure: an in vivo experimental study Lisdiana; Amida, Nurul; Susanti , Dwi; Lamondo, Djuna; Basar, Annisa
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.29404

Abstract

Background: Cigarette smoke contains numerous toxic compounds that generate reactive oxygen species, leading to oxidative stress that can impair reproductive function and induce liver damage. Natural antioxidants such as black garlic have been reported to possess strong free radical–scavenging properties. Purpose: This study aimed to evaluate the protective effects of black garlic extract on sperm quality, liver enzyme levels, and liver histopathology in rats exposed to cigarette smoke. Methods: A randomized post-test-only control group experimental design was used. Twenty-five male Wistar rats were divided into five groups: normal control, cigarette smoke exposure, and three treatment groups receiving black garlic extract at doses of 250, 500, and 1000 mg/kg body weight for 30 days. Sperm concentration, viability, and motility were assessed. Liver function was evaluated using serum ALT and AST levels, and liver histopathology was examined using hematoxylin–eosin staining. Data were analyzed using one-way ANOVA followed by post hoc tests. Results: Cigarette smoke exposure significantly reduced sperm concentration, viability, and motility and induced hepatocellular degeneration and necrosis. Administration of black garlic extract improved sperm parameters and reduced histopathological liver damage, with the most pronounced protective effect observed at a dose of 500 mg/kg body weight. However, no significant differences were observed in serum ALT and AST levels among groups. Conclusion: Black garlic extract exerts protective effects against cigarette smoke–induced reproductive and hepatic damage, with the most effective dose observed at 500 mg/kg body weight. These findings support its potential as a natural antioxidant for mitigating oxidative damage. Further studies are required to elucidate the underlying molecular mechanisms and identify the active compounds responsible for these effects.
Co-Authors Amida, Nurul Basar, Annisa Djuna Lamondo Ferianto Khristina Dias Utami Lisdiana Lutfiyati, Afi