Dewanti, Intan Putri
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Effect of Garlic (Allium sativum) Extract Administration on the Histopathological Features of Mammary Glands in Female Sprague-Dawley Rats Induced with 7,12-Dimethylbenz(a)anthracene (DMBA) Dewanti, Intan Putri; Br Damanik, Efrisca Meliyuta; Amat, Anita Lidesna Shinta; Sasputra, I Nyoman
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.10948

Abstract

Latar Belakang: Kanker adalah penyebab utama kedua kematian secara global, terhitung sekitar 9,6 juta kematian, atau satu dari enam kematian pada tahun 2018. Angka insidensi kanker payudara sebanyak 11.6% dan angka kematian 6,6% pada tahun 2018. Tanaman obat diduga memiliki potensi sebagai antikanker dengan efek samping minimal jika digunakan dengan dosis dan waktu penggunaan yang tepat serta cara penggunaan yang tepat. Tujuan Penelitian : Untuk mengetahui pengaruh pemberian ektrak bawang putih terhadap gambaran histopatologi payudara tikus Sprague-Dawley betina yang diinduksi DMBA. Metodologi : Penelitian ini menggunakan metode eksperimental post test only control group design dengan 6 kelompok perlakuan. Sampel sebanyak 30 tikus setiap kelompok berisi 5 ekor tikus. Data dianalis dengan menggunakan uji normalitas Shapiro-wilk dan uji non-parametrik Kruskal Wallis. Hasil : Hasil penelitian didapatkan tidak terdapat pengaruh pada pemberian ekstrak bawang putih terhadap gambaran histopatologi payudara tikus Sprague-Dawley betina yang diinduksi DMBA. Kelompok 1 epithel duktus normal. Kelompok 2 perubahan epithel duktus hiperplasia dengan atipia. Kelompok 3, kelompok 4, kelompok 5, kelompok 6 perubahan epithel duktus severe hiperplasia. Hasil uji statistik Kruskall-Wallis didapatkan perbedaaan yang tidak signifikan (p>0,05). Hasil uji post hoc Mann-Whitney pada kelompok 1 dan 2 didapatkan perbedaaan yang signifikan (p<0,05). Kesimpulan : Pemberian ekstrak bawang putih (Allium sativum) tidak dapat memberikan perubahan terhadap gambaran histopatologi payudara tikus Sprague-Dawley betina yang diinduksi 7,12 Dimetilbenz(a)antrasen (DMBA).
Effect Of Garlic Extract (Allium sativum) Histopathology Description Of The Breast In Female White Rats Sprague-Dawley Strain Induced 7,12 Dimetilbenz(a)antrasen (DMBA) Dewanti, Intan Putri; Damanik, Efrisca M. Br.; Amat, Anita Lidesna Shinta
Cendana Medical Journal Vol 11 No 1 (2023): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v11i1.10727

Abstract

Background: Cancer is one of leading cause of death number 2 in the world,or one of the six deaths in the 2018. The incidance of breast cancer as much as 11,6% and the number of death are 6,6% in 2018. Medical plant be expacted has potential as an anticancer with minimal side effects when used at the correct dosage, timing and when used it properly. Objectives: To determine the effect of garlic extract on the histopathological picture of female Sprague-Dawley rats induced DMBA. Methodology: This study used an experimental method with a post test only control group design approach using 6 treatment groups. The number of samples was 30 rats with each group containing 5 rats. All data were analyzed using the Shapiro- Wilk normality test followed by the Kruskal Wallis non-parametric test. Results: The results showed that there was no effect on the administration of garlic extract on the histopathological picture of female Sprague-Dawley rats induced DMBA. Group 1 there was no change in the ductal epithel. Group 2 there were changes in the ductal epithelium to hyperplasia with atypia. Group 3, group 4, group 5, group 6 there were changes in the epithelial ducts up to severe hyperplasia. The results of the Kruskall-Wallis statistical test showed that there were no significant differences between groups (p> 0.05). The results of the Mann-Whitney post hoc test in groups 1 and 2 showed a significant difference (p <0.05). Conclusion: DMBA induced can cause changes in the histopathological picture of female Sprague-Dawley rats breast. There was no effect of garlic extract on the histopathological picture of the female Sprague-Dawley rats breasts induced by DMBA.
HUBUNGAN DOKTER DAN PASIEN DI RUMAH SAKIT PENDIDIKAN Nurismail, Eko Novanto; Corputty, Dian Yelisa; Dewanti, Intan Putri; Lada, Christina Olly; Buntoro, Ika Febianti Olly
Cendana Medical Journal Vol 11 No 2 (2023): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v11i2.14003

Abstract

The doctor-patient relationship, in this case communication, empathy and ways of serving patients, can be explored from an early age and continue to be developed and upheld by a doctor for successful therapy and in an effort to improve public health in the future within the teaching hospital environment. The purpose of this review article is to determine the importance of the doctor-patient relationship in a teaching hospital environment. This review uses 40 journals as sources in order to improve doctor-patient relationships in teaching hospitals. From this review it can be concluded that the main goal that young doctors are expected to achieve apart from medical science is soft skills in the form of how to create optimal therapeutic relationships with patients which can be practiced continuously during the professional education period at the Teaching Hospital.