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All Journal Journal of Health and Nutrition Research
Guli, Musjaya
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Medicine & Pharmacology Nursing Public Health

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The Anticancer Activity of Ethanol Extract of Begonia medicinalis on Colorectal Cancer Rat Model Induced With 7,12-Dimethylbenz[A]Anthracene Guli, Musjaya; Ardiputra, Muh Akbar; Pitopang, Ramadanil; Sari, Retno; Hatta, Mochammad; Prawiro, Sumarno Reto; Saifah, Andi; Sardi, Bambang; Rahma, Rahma; Rahmawati, Nurul Dina
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.411

Abstract

Colorectal cancer remains one of the leading causes of cancer-related deaths after lung cancer, highlighting the urgent need for more effective therapies with minimal side effects. Begonia medicinalis has been reported to have potential anticancer properties. This study aimed to evaluate the anticancer activity of Begonia medicinalis extract by assessing neutrophil concentration in a 7,12-dimethylbenz[a]anthracene (DMBA)-induced colorectal cancer rat model. The research employed a laboratory-based experimental approach with a post-test-only group design, comprising five groups with five replications each: treatment group I receiving a 25 mg/kg body weight, treatment group II receiving a 50 mg/kg body weight, treatment group III receiving a 100 mg/kg body weight, an normal group that was not DMBA-induced and did not receive therapy, and a negative control group that was DMBA-induced but did not receive therapy. The results of this study demonstrate that Begonia medicinalis extract effectively suppresses neutrophil concentration in a DMBA-induced colorectal cancer rat model. Treatment with 50 mg/kg body weight and 100 mg/kg body weight doses successfully reduced neutrophil cell levels in the experimental subjects, with the best results seen at the 100 mg/kg body weight dosage. This study provides new insights into the effects of plant-based therapies, Begonia medicinalis extract, in modulating the immune system by suppressing neutrophil concentration in a colorectal cancer rat model.
Ambient Air Pollution Exposure and Social Health Outcomes in Communities Near the Kawatuna Landfill, Palu, Indonesia Saifah, Andi; Ardiputra, Muh. Akbar; Miswan, Miswan; Safirah, Nur Annisa; Arifuddin, Adhar; Guli, Musjaya; Parmin, Parmin
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.540

Abstract

Communities living near landfill sites are often exposed to high levels of ambient air pollution, which may impact their physical and psychosocial health. This study aims to explore the relationship between ambient air pollution exposure, particularly carbon monoxide (CO) and nitrogen dioxide (NO₂), and the social health outcomes of communities residing near the Kawatuna Landfill in Palu, Indonesia. A cross-sectional study involving 143 respondents was conducted using structured interviews and environmental exposure assessments. Correlation analyses, Mann-Whitney U tests, and regression models were applied to examine the relationships between air pollution exposure and respiratory disorders, smoking behavior, stress levels, and social interaction. The findings revealed a significant positive correlation between CO and NO₂ exposure and stress levels (r=0.217, p = 0.022), although the relationship was weak. No significant associations were found between air pollution exposure and smoking behavior, social interaction, or respiratory disorders in multivariate analyses. The Mann-Whitney U test indicated that individuals with respiratory disorders were exposed to higher levels of CO and NO₂ (p = 0.038). Ambient air pollution exposure in this community is more closely related to psychosocial stress than to physical health behaviors or social interaction. Community-based health interventions should consider the cultural context and perceived environmental risks to effectively promote health in such vulnerable populations.
Co-Authors Adhar Arifuddin Andi Saifah Ardiputra, Muh Akbar Ardiputra, Muh. Akbar Bambang Sardi Miswan Miswan Mochammad Hatta Parmin - Prawiro, Sumarno Reto Rahma Rahma Rahmawati, Nurul Dina Ramadanil Pitopang Retno Sari Safirah, Nur Annisa