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Devita Riafinola
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Journal : strada journal of pharmacy

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Antibacterial FormulationEmulgel Preparation Containing 3% Citronella Oil (Cymbopogon Nardus L) With Carbomer 0.5%, 1%, 1.5% Devita Riafinola Andaririt
Strada Journal of Pharmacy Vol. 5 No. 1 (2023): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i1.93

Abstract

Acne is a bacterial infection that can diminish a person's confidence. Acne is caused by the microorganisms Propionibacterium acnes. Citronella oil has citronellal, citronellol, geraniol compounds that contain a very strong antimicrobial activity. Therefore, emulsion-based topical preparations are made with carbomer bases that are suitable for use. This study sought to determine the effect of 0.5%, 1%, and 1.5% carbomer bases with 3% citronella oil extract on the chemical physics properties of emulsion preparations. (Organoleptic, pH, viscosity and dispersion, stability and Freeze-Thaw test). This investigation employed an experimental method to compare three formulas with varying levels of carbomer in an emulsion preparation test for citronella oil extract. The researcher then analysed the chemical substance's physical characteristics. Based on the evaluation results, it was determined that all formulations had identical organoleptic properties, including a silky texture, citronella oil aroma, and a white hue. According to the results of One-Way ANOVA, viscosity, pH, dispersion, stability, and the Freeze-Thaw test, there were no significant variations in the formula.
Testing the Anti-Bacterial Activity of Star Gooseberry Leaves (Souropus Androgynus L) Using the Disc Diffusion Method Using the n-Hexane Fraction Against Propionic Bacterium Acnes Devita Riafinola Andaririt; Ardi Broto
Strada Journal of Pharmacy Vol. 5 No. 2 (2023): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i2.100

Abstract

Acne vulgaris or acne, is a common inflammatory condition in the polysebaceous unit that occurs in teenagers and young adults and is characterized by comedones, papules, pustules, and nodules. One of the factors that causes acne is the Propionic bacterium acnes bacteria. One type of plant with antibacterial properties for acne is the Star Gooseberry Leaf plant (Souropus Androgynus L), which contains alkaloids, saponins, tannins, and flavonoids that act as antibacterials. Susanti (2012). This research aimed to obtain data on the antibacterial activity of the compound components contained in the n-hexane fraction of Star Gooseberry Leaves (Souropus Androgynus L) against the Propionic bacterium acnes bacteria, which can be seen from the inhibition zone. The method used was disc diffusion with three groups of control, namely (K(S), K(+), and K(-)). The test bacteria Propionic bacterium acnes, where the Control Sample consists of 4 test concentrations, namely 30 mg, 60 mg, 120 mg, and 240 mg. The positive control used two µg/disc Clindamycin, while the negative control was 2% DMSO. The results of the disc diffusion test of the ethanol fraction of Star Gooseberry Leaves (Souropus Androgynus L) using the disc diffusion method with concentrations of 30 mg/ml and 60 mg/ml did not provide an inhibition zone, the concentration of 120 mg/ml was 11.1 ± 0.10 mm, the concentration was 240 mg/ml was 14.63 ± 0.25 mm. The negative control DMSO 2% did not provide an inhibitory zone diameter, whereas the positive control Clindamycin 2 µg/disk provided an inhibition zone of 25.47 ± 0.70 mm.
Antibacterial Activity Test of Ashitaba Leaf Extract Ointment Formulation (Angelica Keiskei (miq) Koidz) against Staphylococcus epidermidis Bacteria Luluk Aniqoh Meliana Putri; Devita Riafinola Andaririt
Strada Journal of Pharmacy Vol. 3 No. 1 (2021): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v3i1.138

Abstract

Acne is a condition in which the pores of the skin are blocked, causing inflamed pus pockets. One of the factors causing acne is bacteria. Staphylococcus epidermidis bacteria are bacteria found in acne. The use of medicinal plants is an alternative as a treatment for diseases including diseases caused by bacterial infections. Ashitaba leaves (Angelica Keiskei (miq) Koidz) positively contain alkaloids, saponins, tannins and flavonoids which play a role as antibacterials. The purpose of this study was to determine the antibacterial activity of the formulation of ashitaba leaf extract ointment preparations against Staphylococcus epidermidis bacteria that cause acne, using the well diffusion test method. Observation of the inhibitory power was tested on ashitaba leaf extract and ashitaba leaf extract ointment preparations with extract concentrations of Formula I 10%, Formula II 15%, Formula 20%. The results of this study are that the formulation of ashitaba leaf extract ointment preparations can have inhibitory power against Staphylococcus epidermidis bacteria. The highest inhibition zone in Formula III with an extract concentration of 20% with an inhibition zone diameter value of 7.27 mm.
Formulation And Evaluation Quality Physique Preparation Lip Tint Extract Sweet Potato ( Ipomoea batatas (L.) Lamb) with Extract Dragon Fruit ( Hylocereus polyrhizus ) As a Natural Lip Pigment Poppy Martha Lowra; Devita Riafinola Andaririt; Sri Rahayu Dwi P; Ivan Junius Mesak
Strada Journal of Pharmacy Vol. 6 No. 2 (2024): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i2.147

Abstract

ABSTRACT Introduction: Lip Tint is one of the stock cosmetics that have role in give role decorative on lip pigment coloring . The rise of use dye synthesis in preparation dangerous liptint​ for lips so use material Sweet Potato Nature ( Ipomoea batatas) (L.) Lamb) which is combined Dragon Fruit ( Hylocereus polyrhizus ) can replace dye synthesis in the preparation. Purpose : to know difference concentration extract sweet potato jalar ( ipomoea Batatas (l.) lamb) combination extract fruit dragon ( hylocereus polyrhizus ) against evaluation quality physical . Method: research experimental formulation stock lip tint with using sweet potatoes concentrations of 10%, 20% and 30% combined fruit dragon 6%. Substance color natural contained in sweet potatoes are keratinoids and in fruit dragon that is anthocyanin . Results: In the study This show that stock lip tint sweet potato concentrations of 10, 20 and 30% combined fruit dragon 6%. Yield liptint that has texture , color , aroma, and Power stickiness , power spread , good viscosity . The pH of the preparation is at a value of 8 but No cause irritation to the skin . The results of the data analysis were obtained No there is significant difference in power test spread , power test adhesion and viscosity test and occurs significant differences in pH and FIII were most preferred by respondents . Conclusion: Research This own conclusion concentration sweet potato extract and extract fruit dragon influence results testing quality physique preparation . Quality test results physique show that stock lip tint with sweet potato concentration of 30% (F III) provides results best .
The Potential of Quercetin as Parkinson's Disease Therapy Assessed From Binding Affinity To Adenosine A2a Receptor Using In-Silico Adjie Wahyu Pradana; Sri Rahayu Dwi Purnaningtyas; Devita Riafinola Andaririt; Luluk Aniqoh Meliana Putri
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.156

Abstract

Parkinson's disease is a degenerative disease that causes impaired mobility and muscle control caused by decreased dopamine production in the brain. Parkinson's disease therapy is dopaminergic therapy using levodopa which works by replacing the reduced dopamine, the use of levodopa has side effects such as dizziness, nausea, and excessive sleepiness. The use of istradefylline with levodopa as a non-dopaminergic therapy in parkinson's reduces side effects and increases therapeutic targets. Quercetin is thought to have activity in improving motor function in parkinson's. The aim of this study was to look at the potential of quercetin as a parkinson's therapy. Objective: Finding the activity of quercetin as Parkinson's therapy compared with istradefylline using in-silico. Method: The design of this study is in-silico, which is a study using the help of computer calculations, the method used is molecular docking based on the principle of bonding compounds to receptors. Ligand compounds obtained from PubChem and receptor clusters obtained from Protein Data Bank. The docking Software used is Pyrex, and Discovery Studio Analizer. Independent variables in this study were quercetin and istradefylline, while the dependent variable was binding affinity ligand to adenosine A2a receptor. In this study, statistical analysis was conducted using an independent sample t-test. Results: In-silico test with molecular docking method showed each 9 ligand position to the receptor, the results of data analysis with the test of independent sample t-test, at the degree of significance α = 0.05 obtained statistical results with a significance value of 0.013 which means that the quercetin ligand has stronger potential compared to istradefylline. Quercetin has a binding affinity value of -8.1 kcal/mol, while istradefylline has a binding affinity value of -6.9 kcal / mol. Conclusion: Quercetin has been shown to have potential as an alternative therapy for parkinson's disease
A Physical Quality and Antioxidant Test of Strawberry Leaf Fraction Lotion DPPH Method (1,1- Diphenyl-2- Picryhydrazyl) Candra Asih Setyaningrum, Candra; Arif Wijayanto; Juvita Herdianty; Devita Riafinola Andaririt
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.176

Abstract

Lotion is a cosmetic preparation that functions to moisturize and protect the skin by providing a soothing effect. This research utilizes natural ingredients in the form of strawberry leaf extract (Fragaria vesca) to create a lotion formulation with high antioxidant activity. The objective of this study is to determine the effect of varying concentrations of strawberry leaf extract on the physical quality and antioxidant activity of the lotion. This experimental study involved formulating lotions with different concentrations of strawberry leaf extract at 2%, 4%, and 6%. The antioxidant activity was evaluated using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method to measure the extract's ability to scavenge free radicals. The main active component in strawberry leaf extract is polyphenol compounds, which act as natural antioxidants in cosmetic products. The results showed that the strawberry leaf fraction lotion had a soft texture, green color, and a characteristic strawberry leaf scent. The pH test had a significance value of 0.00. The viscosity test also had a significance value of 0.00. The adhesion test results showed a significance value of 0.00, and the spreadability test also had a significance value of 0.00. The DPPH antioxidant test showed regression values of 0.932 for the positive control, 0.854 for the negative control, 0.948 for F1, 0.985 for F2, and 0.967 for F3. This study provides strong evidence that strawberry leaf fraction is suitable as an active ingredient in antioxidant cosmetic products, with the potential to compete with conventional ingredients. The SPSS test results showed a significant effect of concentration on free radical inhibition, as well as significant differences in pH, spreadability, and adhesion tests among the formulations. However, some groups did not meet the assumptions of normality and homogeneity, indicating the need for alternative analytical methods for further validation
Formulation and Physical Quality Evaluation of Cyperus rotundus L. Water Fraction Gel Alfara Derista Felany; Juvita Herdianty; Devita Riafinola Andaririt; Ivan Junius Mesak
Strada Journal of Pharmacy Vol. 8 No. 1 (2026): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v8i1.202

Abstract

The development of topical preparations from natural ingredients requires rigorous physical quality evaluation to ensure their safety, stability, and efficacy. This study aimed to formulate and evaluate the physical quality of a gel preparation containing the water fraction of Cyperus rotundus L. at various concentrations. The water fraction of the rhizome was formulated into gel preparations with concentrations of 5% (F1), 10% (F2), 15% (F3), and 20% (F4) using Carbopol 940 as a gelling agent. The physical quality evaluation included organoleptic tests, homogeneity, pH, spreadability, adhesion, and viscosity. The results showed that all gel formulas met the established physical quality requirements. An increase in the concentration of the water fraction significantly affected the physical characteristics of the preparation, such as a more intense color, as well as an increase in pH, adhesion, and viscosity. All formulas exhibited a pH suitable for the physiological range of the skin (5.53–6.80), good spreadability (5.49–6.77 cm), and adequate adhesion (>2 seconds). It was concluded that the nut grass rhizome water fraction gel has stable and acceptable physical characteristics, making it a potential candidate for further development as a topical preparation.
Co-Authors Adjie Wahyu Pradana Agus Wahyudi Alfara Derista Felany amalianurzahra Ardhi Broto Sumanto Arif Wijayanto Candra Asih Setyaningrum, Candra Ivan Junius Mesak Juvita Herdianty Novi Kurniasari Poppy Martha Lowra Purnaningtyas, Sri Rahayu Dwi Putri, Luluk Aniqoh Meliana Ratna Wardani Sri Rahayu Dwi P Tutus Fibri