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All Journal Journal of Biobased Chemicals (JOBC) Analit: Analytical And Environmental Chemistry
Sinta Bella Triyanti
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Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science

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Evaluation of Nutmeg Extract as a Natural Anti-Acne Agent Against P. acnest Sari, Indah; Angga Saputra Yasir; Indarto I; Sinta Bella Triyanti; Aida Febina Sholeha; Veni Putri Nurhayati
Journal of Biobased Chemicals Vol. 5 No. 1 (2025): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jobc.v5i1.5590

Abstract

Acne vulgaris is a common inflammatory skin disorder primarily caused by the proliferation of Propionibacterium acnes. In response to increasing demand for natural and safer therapeutic alternatives, this study investigated the phytochemical composition, total flavonoid content, and antibacterial activity of the ethanolic extract of Myristica fragrans flesh. Phytochemical screening revealed the presence of flavonoids, terpenoids, tannins, saponins, and alkaloids—classes of compounds widely recognized for their antimicrobial properties. The total flavonoid content (TFC), determined using the aluminum chloride colorimetric method, was found to be 0.1582 ± 0.0044 mg quercetin equivalents per gram of dry extract. Antibacterial assays using the disc diffusion method demonstrated dose-dependent inhibition of both Staphylococcus aureus and P. acnes, with greater efficacy observed against P. acnes. These results suggest that nutmeg flesh extract possesses significant antibacterial potential, particularly as a candidate for anti-acne cosmetic formulations. Moreover, this study highlights the underexplored value of nutmeg flesh—a byproduct of spice processing—as a sustainable source of bioactive compounds for skincare applications.
CHOLINE CHLORIDE BASED DEEP EUTECTIC SOLVENTS: PHYSICOCHEMICAL PROPERTIES AND SPECTROSCOPIC INSIGHTS Indah Puspita Sari; Annisaa Siti Zulaicha; Sinta Bella Triyanti
Analit : Analytical and Environmental Chemistry Vol. 9, No. 02 October (2024) Analit : Analytical and Environmental Chemistry
Publisher : Jurusan Kimia FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/analit.v9i02.200

Abstract

This study focuses on the synthesis and characterization of Choline Chloride-based Deep Eutectic Solvents (DES) using Citric Acid (ChCl+CA) and Malic Acid (ChCl+MA) as hydrogen bond donors. The DES were prepared at various molar ratios, and their physicochemical properties, including viscosity, density, pH, water content, and molecular interactions, were comprehensively analyzed. The FTIR spectroscopic analysis revealed key shifts in the functional groups, indicating strong hydrogen bonding between the DES components. While ChCl+CA and ChCl+MA successfully formed stable eutectic solvents at a 1:1 molar ratio, synthesis with higher molar ratios (1:2 and 1:3) and ChCl+Ethylene Glycol (ChCl+EG) were unsuccessful, highlighting the importance of component compatibility and molar ratios. The density and viscosity measurements showed the potential applicability of these DES in extraction processes. This research contributes to the development of DES as green solvents, with future applications in pigment extraction for cosmetic purposes.   Keywords: Deep Eutectic Solvents, Choline Chloride, Citric Acid, Malic Acid, Pigment Extraction, Cosmetic Applications
Co-Authors Aida Febina Sholeha Angga Saputra Yasir Annisaa Siti Zulaicha Indah Puspita Sari Indarto I Mochammad Imron Awalludin Veni Putri Nurhayati