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All Journal Journal of Biobased Chemicals (JOBC)
Sinta Bella Triyanti
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Chemical Engineering, Chemistry & Bioengineering Chemistry

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Evaluation of Nutmeg Extract as a Natural Anti-Acne Agent Against P. acnest Sari, Indah; Angga Saputra Yasir; Indarto I; Sinta Bella Triyanti; Aida Febina Sholeha; Veni Putri Nurhayati
Journal of Biobased Chemicals Vol. 5 No. 1 (2025): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jobc.v5i1.5590

Abstract

Acne vulgaris is a common inflammatory skin disorder primarily caused by the proliferation of Propionibacterium acnes. In response to increasing demand for natural and safer therapeutic alternatives, this study investigated the phytochemical composition, total flavonoid content, and antibacterial activity of the ethanolic extract of Myristica fragrans flesh. Phytochemical screening revealed the presence of flavonoids, terpenoids, tannins, saponins, and alkaloids—classes of compounds widely recognized for their antimicrobial properties. The total flavonoid content (TFC), determined using the aluminum chloride colorimetric method, was found to be 0.1582 ± 0.0044 mg quercetin equivalents per gram of dry extract. Antibacterial assays using the disc diffusion method demonstrated dose-dependent inhibition of both Staphylococcus aureus and P. acnes, with greater efficacy observed against P. acnes. These results suggest that nutmeg flesh extract possesses significant antibacterial potential, particularly as a candidate for anti-acne cosmetic formulations. Moreover, this study highlights the underexplored value of nutmeg flesh—a byproduct of spice processing—as a sustainable source of bioactive compounds for skincare applications.
Evaluation of Nutmeg Flesh Extract as a Natural Anti-Acne Agent Against Cutibacterium acnes Angga Saputra Yasir; Indah Puspita Sari; Indarto I; Sinta Bella Triyanti; Aida Febina Sholeha; Veni Putri Nurhayati
JOBC Vol. 5 No. 1 (2025): Journal of Biobased Chemicals
Publisher : University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acne vulgaris is a common chronic inflammatory skin disorder primarily caused by Cutibacterium acnes infection. This study aims to investigate the phytochemical composition, total flavonoid content, and antibacterial activity of the ethanolic extract of Myristica fragrans fruit flesh against C. acnes and Staphylococcus aureus. The dried fruit flesh was extracted using ultrasonic-assisted ethanol extraction, followed by qualitative phytochemical screening and total flavonoid quantification via the aluminum chloride colorimetric method. Antibacterial activity was evaluated using the disc diffusion method at extract concentrations of 10%, 20%, and 30%, with standard antibiotics as positive controls. The extract contained key bioactive compounds including flavonoids, terpenoids, tannins, saponins, and alkaloids. Total flavonoid content averaged 0.15820 ± 0.00440 mg quercetin equivalent per gram of dry extract. The extract exhibited dose-dependent antibacterial effects, with more potent inhibition against C. acnes than S. aureus. Inhibition zones at 30% concentration reached notable diameters, confirming significant antibacterial activity based on CLSI standards. These findings highlight the potential of M. fragrans fruit flesh as a promising natural source of multifunctional bioactive compounds for anti-acne cosmeceutical development. Further studies involving compound isolation and in vivo efficacy testing are recommended to support its clinical application.
Co-Authors Aida Febina Sholeha Angga Saputra Yasir Angga Saputra Yasir Annisaa Siti Zulaicha Indah Puspita Sari Indarto I Mochammad Imron Awalludin Veni Putri Nurhayati