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All Journal Berkala Kedokteran Journal of Pharmaceutical Care and Sciences Sains Medisina
Rizantha, M. Iqbal
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Review Artikel: Potensi Daun Meniran (Phyllanthus niruri L.) Sebagai Antivirus Influenza Nastiti, Kunti; Lisaura, Inggrit Windy; Husnati, Lailan; Bariroh, Laili; Rizantha, M. Iqbal
Sains Medisina Vol 3 No 6 (2025): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v3i6.797

Abstract

Penelitian ini bertujuan untuk mengkaji potensi daun meniran (Phyllanthus niruri L.) sebagai agen antivirus terhadap virus influenza melalui pendekatan kajian literatur. Latar belakang penelitian ini didasarkan pada meningkatnya kebutuhan terhadap alternatif terapi yang aman, alami, dan efektif untuk menangani infeksi influenza yang bersifat akut, mudah menular, dan sering mengalami mutasi genetik. Metode yang digunakan berupa telaah pustaka terhadap enam artikel ilmiah terpilih yang dipublikasikan antara tahun 2022 hingga 2025. Artikel-artikel tersebut dianalisis secara kualitatif melalui pendekatan analisis isi dan sintesis naratif, mencakup studi in vitro, in vivo, serta formulasi sediaan farmasi. Hasil kajian menunjukkan bahwa P. niruri memiliki aktivitas antivirus yang bekerja melalui penghambatan replikasi virus, peningkatan produksi interferon gamma (IFN-γ), serta stimulasi sistem imun adaptif. Selain itu, formulasi tablet hisap ekstrak meniran dan aplikasi dalam pakan unggas atau biosintesis nanopartikel memperluas potensi terapetik tanaman ini. Meniran juga terbukti mampu meningkatkan titer antibodi terhadap vaksin influenza pada hewan uji. Dengan demikian, P. niruri dinilai berpotensi tinggi sebagai terapi tambahan atau pencegahan berbasis herbal terhadap influenza.
A Analisis Kandungan Bahan Kimia Obat Natrium Diklofenak Dalam Jamu Encok Lisaura, Inggrit Windy; Hastika, Febby Yulia; Manurung, Davidson; Mara, Ignatius Ronaldy; Husnati, Lailan; Bariroh, Laili; Rizantha, M. Iqbal
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 2 (2024): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i2.574

Abstract

Background: Jamu is a traditional herbal medicine made from natural ingredients, inherited as a cultural heritage passed down from generation to generation for health purposes. The increasing use of jamu has led some producers to add pharmaceutical chemicals (BKO) to their products, which can be dangerous and cause side effects for consumers. Purpose: This study aims to analyze the content of sodium diclofenac in jamu used for joint pain relief. Methods: The research methodology includes a qualitative approach using Thin Layer Chromatography (TLC) and a quantitative approach using UV-VIS Spectrophotometry. Results:  The qualitative analysis using TLC on the jamu pegel linu/encok sample tested positive for sodium diclofenac with an Rf value of 0,87. The quantitative test using UV-Vis spectrophotometry yielded an a value of 0,092, a b value of 0,114, and an r value of 0,993. The concentration of sodium diclofenac in the jamu pegel linu sample was found to be 18,90 ppm. Conclusion: The tested jamu sample for joint pain relief contains sodium diclofenac and is not suitable for distribution.  
Determination of Flavonoid Levels and Anti-Inflammatory Activity of Lime Root Extract (Citrus aurantifolia) by Granuloma Pouch Method Mukti, Yusuf Anggoro; Rohama, Rohama; Jannah, Ghina Raudhatul; Rizantha, M. Iqbal; Daud, Muhammad Alfian
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24410

Abstract

Non-communicable diseases (NCDs) are still the leading cause of death at the global level. In Indonesia, NCDs contribute 71% of the total mortality rate. One of the causes of non-communicable diseases is the occurrence of oxidative stress in the body which is a condition of imbalance between free radical compounds and antioxidants. One of the sources of free radical formation in the body is when the inflammatory process occurs. Lime is used by the Indonesian people as a seasoning for cooking or empirically as an appetite enhancer, antipyretic and antibacterial. Research states that  lime root extract has very strong antioxidant activity with an IC50 value of 24.81 ppm and positively contains alkaloids, flavonoids, saponins and tannins. Flavonoids are thought to act as antioxidants and anti-inflammatory through their ability to donate hydrogen atoms and the ability to bind prostaglandins, COX-1 and COX-2 and lipooxygenase enzymes. The very strong antioxidant activity and the presence of flavonoids contained make lime root have the potential as an anti-inflammatory. Determination of flavonoid levels of lime root extract using UV-Vis spectrophotometry method with quercetin as a comparison and testing of anti-inflammatory activity of lime root extract using the Granuloma Pouch  method using mouse test animals. The results showed that the total flavonoid level was 36.8 mg QE (Quersetin Equialen)/g or 3.68%. And itexerts an anti-inflammatory effect through its ability to reduce the volume of exudate, lower the total exudate leukocytes, and lower the number of neutrophils in the exudate, most notably at a concentration of lime root extract of 20%.
Co-Authors Bariroh, Laili Daud, Muhammad Alfian Hastika, Febby Yulia Husnati, Lailan Jannah, Ghina Raudhatul Lisaura, Inggrit Windy Manurung, Davidson Mara, Ignatius Ronaldy Mukti, Yusuf Anggoro Nastiti, Kunti Rohama, Rohama