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Journal : health dynamics

Visualization of the Macrophage's Dynamic in TB-HIV Co-Infection Using the Molecular Imaging Techniques: A Narrative Review Fuad Minan Zuhri
Health Dynamics Vol 1, No 2 (2024): February 2024
Publisher : Knowledge Dynamics

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hd10205

Abstract

Introduction: Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) collaborate in order to weaken the immune system and increase the burden of both illnesses. Macrophages as the first intracellular niche against Mtb infection, are also involved in the persistence of the HIV infection, and may have an important role in the of tuberculosis (TB)-HIV co-infection. Improved knowledge of the macrophage function and pathogenesis dynamics may contribute to the development of newer and better diagnosis technique, prognosis assessment, and therapeutic intervention. By monitoring changes in the expression of molecular targets, macrophage identification methods that use molecular imaging techniques for cell image analysis can efficiently provide important information about macrophage biology and evaluate early response to therapy, which can facilitate medical personnel in the identification and treatment of TB-HIV disease. Methods: This study is a narrative review highlighting the utilization of molecular imaging techniques to capture macrophage dynamics in TB-HIV co-infection. Result and conclusion: Confocal laser scanning microscopy live imaging, flow cytometry, immunofluorescence microscopy, histochemical staining, scanning electron microscopy (SEM), and deconvolution microscopy images are among several molecular imaging techniques that can be used to visualize macrophage dynamics in TB-HIV co-infection.
Differences in Psychological Well-Being Between Healthcare Professionals and Health Science Students Participating in a Psychological Well-Being Training Program Nova Khairunnisa; Fasayu Berliana Agustin; Fuad Minan Zuhri; Rizqi Ulin Nuha; Imam Faisal Hamzah
Health Dynamics Vol 3, No 4 (2026): April 2026
Publisher : Knowledge Dynamics

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hd30402

Abstract

Background: Psychological well-being (PWB) refers to an individual’s ability to accept oneself, establish positive relationships with others, demonstrate autonomy in decision-making, manage environmental demands, maintain a clear sense of purpose in life, and continuously experience personal growth. In the healthcare context, PWB is essential because it is closely related to the quality of healthcare services and the effectiveness of the educational process among health science students. Differences in professional experience and developmental stages between healthcare professionals and students may lead to variations in their PWB profiles. This study aimed to analyze differences in PWB healthcare professionals and health science students who participated in a PWB training program. Methods: This study employed a quantitative approach using a cross-sectional comparative design. The participants consisted of 194 individuals, including 105 active healthcare professionals and 89 health science students who participated in a PWB training program organized by the Health Division of the Regional Board of the Muhammadiyah Student Association in Central Java. PWB was assessed using a questionnaire adapted from the instrument developed by Kartika (2014) and grounded in Ryff’s PWB model, which encompasses six core dimensions for evaluating PWB among healthcare professionals and health science students. Data were analyzed using the Mann–Whitney U test to examine differences between the two groups. Results: The results showed that most indicators of PWB differed significantly between healthcare professionals and health science students, particularly in the dimensions of self-acceptance, autonomy, and environmental mastery. Conclusion: There are significant differences in PWB profiles between healthcare professionals and health science students. These findings highlight the importance of developing PWB training programs that consider the specific needs and characteristics of each group so that mental health interventions can more effectively support healthcare service quality and educational processes in the health sector.
Visualization of the Macrophage's Dynamic in TB-HIV Co-Infection Using the Molecular Imaging Techniques: A Narrative Review Fuad Minan Zuhri
Health Dynamics Vol 1, No 2 (2024): February 2024
Publisher : Knowledge Dynamics

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hd10205

Abstract

Introduction: Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) collaborate in order to weaken the immune system and increase the burden of both illnesses. Macrophages as the first intracellular niche against Mtb infection, are also involved in the persistence of the HIV infection, and may have an important role in the of tuberculosis (TB)-HIV co-infection. Improved knowledge of the macrophage function and pathogenesis dynamics may contribute to the development of newer and better diagnosis technique, prognosis assessment, and therapeutic intervention. By monitoring changes in the expression of molecular targets, macrophage identification methods that use molecular imaging techniques for cell image analysis can efficiently provide important information about macrophage biology and evaluate early response to therapy, which can facilitate medical personnel in the identification and treatment of TB-HIV disease. Methods: This study is a narrative review highlighting the utilization of molecular imaging techniques to capture macrophage dynamics in TB-HIV co-infection. Result and conclusion: Confocal laser scanning microscopy live imaging, flow cytometry, immunofluorescence microscopy, histochemical staining, scanning electron microscopy (SEM), and deconvolution microscopy images are among several molecular imaging techniques that can be used to visualize macrophage dynamics in TB-HIV co-infection.