<![CDATA[Dyslipidemia, an abnormality in lipid metabolism marked by elevated triglycerides, cholesterol, or LDL and low HDL, increases cardiovascular risk. Tamarillo (Solanum betaceum Cav.) contains flavonoids and anthocyanins with potential lipid-lowering effects. This study evaluated the effect of ethanol extract of Tamarillo fruit (ETB) at doses of 100 mg/kg body weight (BW)/day and 200 mg/kg BW/day on triglyceride levels in Wistar rats with dyslipidemia, compared with simvastatin at 10 mg/kg BW/day. A posttest-only control group design was applied using 25 male Wistar rats divided into five groups: negative control, positive control, ETB 100, ETB 200, and simvastatin. Dyslipidemia was induced with a high-fat diet and propylthiouracil for 14 days, followed by 14 days of treatment. Triglyceride levels were measured using the GPO-PAP method. Data were analyzed with the Shapiro–Wilk test, Levene’s test, and Kruskal–Wallis test. 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