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IN SILICO STUDY INVESTIGATING TO KEAP1-KELCH INHIBITORY POTENTIAL OF PLUCHEA INDICA LEAVES BIOACTIVE COMPOUNDS Ria Rismawati; Mar'atus Sholihah; Nur Fajar Aprilia Sari
Nusantara Hasana Journal Vol. 5 No. 4 (2025): Nusantara Hasana Journal, September 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i4.1704

Abstract

Pluchea indica (beluntas) is a herbal drug candidate that has a high antioxidant capacity. This research reports the analysis of ligand-protein interactions, drug-like properties, biological activity, and prediction of ADMET profile of bioactive compounds contains in P. indica leaves as antioxidants. The interaction of the ligand-KEAP1 resulted in the lowest binding affinity value for the stigmasterol compound with a weight of -12.1 Kcal/mol with several chemical bonds formed and produced amino acid residues. Analysis of drug-like properties using SwissADME showed that P. indica complied with all parameters of Lipinski's rule. Biological activity with online PASS test showed high biological activity as an antioxidant. Finally, prediction of ADMET profile using admetSAR showed that P. indica had good pharmacological criteria.
PEMANFAATAN LIMBAH SANDBLASTING INDUSTRI PERKAPALAN MENJADI PRODUK BATA BETON PEJAL MENDUKUNG MATERIAL HIJAU Nur Fajar Aprilia Sari; Luqman Cahyono; Amanda Rosalina; Maret’atus Sholihah; Ria Rismawati; Ovi Prina Gastriani; Muhammad Akbar Febianto
Nusantara Hasana Journal Vol. 5 No. 4 (2025): Nusantara Hasana Journal, September 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i4.1705

Abstract

Indonesia, as a maritime country, has industrial activities that generate a large amount of waste. One of the largest waste-producing sectors is the shipping industry, particularly from ship maintenance and repair activities in shipyards. In this industry, there is a process called sandblasting, which is used to clean ship surfaces from rust, old paint, and other contaminants. The silica sand used in this sandblasting process is classified as hazardous and toxic waste (B3 waste). This waste poses a risk of environmental pollution if not properly managed.The research problem in this study is how to utilize sandblasting waste as an alternative material in the production of solid concrete bricks. The objective of the study is to process this waste into technically and environmentally feasible solid concrete bricks. The methods used include chemical characterization of raw materials using XRF, making test specimens in the form of 50 × 50 × 50 mm cubes, and conducting compressive strength and TCLP (Toxicity Characteristic Leaching Procedure) tests. The results show that the A2 variation produced a compressive strength of 142 kg/cm², exceeding the SNI 03-0349:1989 standard for quality I concrete bricks, and the TCLP test results indicated that the levels of Cu and Cr met the quality standards set by Government Regulation No. 22 of 2021. Therefore, solid concrete bricks made from hazardous and toxic waste are considered feasible as an environmentally friendly alternative construction material.
DESAIN PROTOTIPE UNIT FILTRASI UNTUK PENGOLAHAN LIMBAH AIR WUDHU Mar’atus Sholihah; Vivin Setiani; Ria Rismawati; Nora Amelia Novitrie; Sekarsari Wibowo; Nur Fajar Aprilia Sari
Nusantara Hasana Journal Vol. 5 No. 5 (2025): Nusantara Hasana Journal, October 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aims to design and evaluate a simple prototype filtration unit for the treatment of ablution (wudhu) wastewater generated from religious facilities. Ablution water is categorized as domestic wastewater that is commonly discharged directly into the environment without prior treatment, although it still poses a potential risk of pollution. The developed prototype employs a multi-layer filter configuration consisting of palm fiber, zeolite, activated carbon, and sponge, with a total media height of 40 cm and an operational flow rate of 100 L/h. Based on design calculations, the system achieved a Hydraulic Loading Rate (HLR) of 0.4 m³/m²·h and an Empty Bed Contact Time (EBCT) of 60 minutes, indicating conservative hydraulic characteristics with a relatively long contact time. Performance testing showed that the filtration unit effectively reduced turbidity from 3 NTU to 1.2 NTU, achieving a removal efficiency of 88%, and increased the pH value from 5.6 to 7.0, thereby meeting the Class II water quality standard as regulated in Government Regulation No. 22 of 2021. These findings demonstrate that the designed filtration system is effective in improving the physical quality of ablution wastewater and has strong potential for application in public facilities such as mosques and educational institutions to support water conservation and sustainable wastewater management.