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All Journal Sari Pediatri Paediatrica Indonesiana
Santoso, Dara Ninggar
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Health Professions Medicine & Pharmacology

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Predictors of pediatric Henoch-Schönlein purpura recurrence Santoso, Dara Ninggar; Kurniati, Nia; Hendarto, Aryono; Chozie, Novie Amelia; Prawira, Yogi; Marsubrin, Putri Maharani Tristanita
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.307-15

Abstract

Background Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children and is usually self-limited with a favorable prognosis. However, recurrence in children is associated with a poorer prognosis, i.e., a higher risk of progressing to chronic kidney disease (CKD) as a long-term complication. In Indonesia, the recurrence rate of HSP and its predictors in children have not been well established . Objective To estimate the incidence of recurrent HSP and determine its predictors in children at Dr. Cipto Mangunkusumo National General Hospital (RSCM). Methods A retrospective cohort review of medical records followed children aged <18 years at RSCM for 6 months after HSP diagnosis based on the the European League Against Rheumatism (EULAR)/ Paediatric Rheumatology European Society (PRESS)/Paediatric Rheumatology International Trials Organization (PRINTO) criteria. Multivariate, Cox logistic regression, and Kaplan-Meier analyses were performed. Results This study included 116 children aged 2–17 years with HSP. Twenty-six (22.4%) of the subjects experienced recurrence, with an incidence of 3.56 per 100,000 person-years. The only statistically significant predictor for recurrence was  the presence of infection after the first episode of HSP (HR 11.301; 95%CI 4.327 to 29.519; P<0.001). The cumulative survival of subjects with infection for recurrence over 6 months  was  51%, with mean 5.3 months survival duration (95%CI 4.76 to 5.99; P< 0.0001). Chronic kidney disease, a long-term complication of HSP, was noted in 22 (19%) participants. Conclusion Recurrence of HSP was  observed in 22.4% of our subjects within 6 months follow up. However, subjects with a history of infection after their first episode of HSP resolution should be notified about the possibility of recurrence. Chronic kidney disease occurred in 22 participants (19%), possibly becoming a long-term complication of HSP.
Efek Penggunaan Deksametason Ajuvan untuk Meningitis Bakteri pada Anak Handryastuti, Setyo; Rafli, Achmad; Wicaksono, Yuda Satrio; Mangunatmadja, Irawan; Soebadi, Amanda; Santoso, Dara Ninggar
Sari Pediatri Vol 25, No 6 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.6.2024.405-13

Abstract

Latar belakang. Meningitis bakterial pada anak, umumnya disebabkan oleh Streptococcus pneumoniae, Neisseria meningitidis, dan Haemophilus influenzae tipe b. Penggunaan deksametason sebagai terapi ajuvan untuk antibiotik masih menjadi perdebatan pada kasus meningitis bakterialis anak karena adanya bukti yang kontradiktif mengenai dampaknya terhadap hasil luaran klinis.Tujuan. Meninjau literatur yang ada mengenai efek dari penggunaan deksametason pada meningitis bakteri pada anak, dengan fokus pada morbiditas, mortalitas, dan efek samping.Metode. Pencarian literatur sistematis dilakukan menggunakan database Pubmed, EMBASE, Scopus, dan Cochrane. Studi yang memenuhi kriteria inklusi adalah uji klinis acak atau meta-analisis, diterbitkan dalam bahasa Inggris, dilakukan dalam 10 tahun terakhir, dan membandingkan efek penggunaan deksametason pada meningitis bakterial anak.Hasil. Lima meta-analisis disertrakan dalam tinjauan ini. Tidak terdapat penurunan signifikan dalam mortalitas dengan penggunaan deksametason dibandingkan plasebo. Konsistensi temuan menunjukkan manfaat deksametason pada fungsi pendengaran pasien meningitis bakteri. Efek terhadap kelainan neurologis masih belum jelas, dan efek samping cenderung serupa antara kelompok yang diobati dan tidak.Kesimpulan. Bukti menunjukkan potensi manfaat deksametason pada fungsi pendengaran anak dengan meningitis bakteri. Namun, dampak terhadap mortalitas dan kelainan neurologis masih memerlukan penelitian lebih lanjut. Keputusan penggunaan deksametason harus dipertimbangkan dengan hati-hati oleh dokter, sementara penelitian lanjutan, terutama dosis optimal untuk hasil neurologis, diperlukan.
Co-Authors Aryono Hendarto Irawan Mangunatmadja Marsubrin, Putri Maharani Tristanita Nia Kurniati Novie Amelia Chozie Rafli, Achmad Setyo Handryastuti, Setyo Soebadi, Amanda Wicaksono, Yuda Satrio Yogi Prawira, Yogi