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All Journal HAYATI Journal of Biosciences Cermin Dunia Kedokteran
Nathasia
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Health Professions

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Effect of Porang (Amorphophallus muelleri Blume) Flour Diet on Postprandial Blood Sugar Rates and Insulin Resistance in Male Wistar Rats (Rattus norvegicus) Diabetes Mellitus Nathasia; Widhiartini, Ida Ayu Alit; Dwipayana, I Made Pande; Wahyuni, Nila; Maratni, Ni Putu Tesi; Hendrayana, Made Agus
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.95-102

Abstract

Medical nutrition therapy is essential in diabetes management, especially as diabetes is often linked with aging. Porang tuber flour contains glucomannan, a compound with potential glucose-lowering effects. This study aimed to evaluate the effect of porang flour feeding frequency on 2-hour postprandial blood glucose (2hPPBG) and HOMA-IR in diabetic rats. Using a quasi-experimental pre-test and post-test control group design, 21 male Wistar rats were induced with diabetes via streptozotocin and nicotinamide, then randomly assigned to three groups: G0 (control, given aquadest), G1 (porang flour 300 mg/kg BW daily), and G2 (porang flour 300 mg/kg BW every two days). Five rats died during treatment. Wilcoxon test results showed a difference in 2hPPBG levels between each group before and after treatment. There was no decrease in G0 (p = 0.893), but a decrease in G1 (p = 0.043) and G2 (p = 0.028). The difference between HOMA-IR before and after treatment did not decrease in groups G0 (p = 0.345), G1 (p = 0.138), and G2 (p = 0.249). Post hoc test for 2hPPBG levels between groups showed a significant difference between G0 and G1 (p<0.001), a significant difference between G0 and G2 (p<0.001), and no significant difference between G1 and G2 (p = 0.135). One-way ANOVA test of HOMA-IR showed no significant difference between G0, G1, and G2 (p = 0.148). It was concluded that porang flour can reduce 2hPPBG, but not HOMA-IR. There was no difference in 2hPPBG levels between administering porang flour daily and every other day.
Uremic Frost - Kelainan Kulit pada Gagal Ginjal Kronik Nathasia; Wijayadi, Linda Julianti
Cermin Dunia Kedokteran Vol 47 No 9 (2020): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i9.567

Abstract

Uremic frost merupakan kelainan kulit yang jarang, karena ditemukan pada pasien gagal ginjal kronik yang belum menjalani hemodialisis. Kelainan ini ditandai dengan lapisan putih kekuningan akibat kristal urea yang mengendap di permukaan kulit. Seorang wanita 44 tahun datang dengan keluhan utama kulit kering, bersisik, dan gatal seluruh tubuh sejak 1 bulan. Pasien baru didiagnosis gagal ginjal kronik. Pada pemeriksaan dermatologi didapatkan makula hiperpigmentasi, berbatas tegas, multipel, ukuran lentikular-plakat, dan krusta putih kekuningan. Tatalaksana dermatologi uremic frost adalah dengan pelembap dan antihistamin oral, pengobatan lebih lanjut untuk penyakit ginjal yang mendasari. Uremic frost is a rare skin disorder, found in chronic kidney failure patients who have not undergone hemodialysis. This disorder is characterized by yellowish white layer on the skin surface due to urea crystals. A 44-year-old female patient presented with dry, scaly, and itchy skin on the whole body in the last 1 month. The patient has just been diagnosed with chronic kidney failure. Dermatological examination revealed hyperpigmented macules, well-defined, multiple, lenticular-placard size and also a yellowish-white crust. Management in dermatology is with moisturizers and oral antihistamines, further treatment should be given to underlying kidney disease.
Co-Authors I Made Pande Dwipayana I.A.A. Widhiartini Made Agus Hendrayana Ni Putu Tesi Maratni Nila Wahyuni