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Panjaitan, Riong Seulina
Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta. Scopus ID: 57211394035
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Journal : Jurnal Kimia Mulawarman

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Studi Penambatan Molekul Flavonoid Pada Reseptor α-Glukosidase menggunakan PLANTS Budi Mulyati; Riong Seulina Panjaitan
JURNAL KIMIA MULAWARMAN Vol 18 No 2 (2021)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v18i2.1004

Abstract

ABSTRACT Plants that contain flavonoids are widely used in traditional medicine. Flavonoids can reduce blood glucose levels with their ability as anti-oxidants. The purpose of this study was to determine natural compounds from flavonoid derivatives that have good affinity and conformation and their interactions in inhibiting α-glucosidase (an enzyme that breaks down carbohydrates into glucose) and determine the sequence of ligands that interact more strongly with α protein / enzyme α-glucosidase. Molecular docking is a computational method that aims to imitate the interaction of a ligand molecule with the protein it targets in in-vitro tests. Molecular docking between flavonoids and α-glucosidase receptors was carried out using the PLANTS method to see its affinity. The flavonoids used as ligands were flavones, flavanols and chalcone with the results of the docking scores respectively, -65.41, -64.39 and -63.07 where the standard ligand used in this study was deoxynojirimycin (-77.12). In the active side of the α-Glucosidase enzyme that binds to flavonoid ligands is Gly 555, Glu 526 and Pro 556.
Co-Authors Ade Ramadhan Anggraeni, Vina Juliana Ani Rombe Sarungngu’ Bayuadi Bayuadi Budi Mulyati, Budi Dewi Kurnia Dwi Handayani Dwi Yunisa Dinli Fida Madayanti Fida Madayanti Warganegara Haidar Dwi Putranto Liany Carolina Rambu Lika Liany Carolina Rambulika Lidya Natalia Lika Lastri Sitorus Marisa Tamara Sari Maya Purnama Mei Syara Nabila Mifta Damayanti Nurul Asfia Purwati Purwati Purwati Purwati Rabima Rabima Regina Regina Rika Parisa Riri Dwi Apriia Risty Setyati Ashari Rizki, Sandi Muhammad Sahda Sabilah Luhtansa Saiful Anwar Sandi Muhammad Rizki Sany Yulianti Septiana Berbara Blaon Seviana Utami Lestari Silvy Widya Rahmi Sutriningsih Sutriningsih Violetta Djohansah Zuraida Sagala