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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Journal of Halal Science and Research
Kartikasari, Ayu Lifia Nur
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Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Other

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Journal : Journal of Halal Science and Research

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Optimization of naringenin sunscreen cream formula using the simplex lattice design method Kartikasari, Ayu Lifia Nur; Wibowo, Anisa Devi Kharisma; Kuncahyo, Ilham
Journal of Halal Science and Research Vol. 4 No. 2 (2023): September
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jhsr.v4i2.7172

Abstract

Naringenin is a pure isolate belonging to a group of flavonoid compounds with pharmacological effects such as anti-inflammatory, anticancer, antiatherogenic, antifibrogenic, and antioxidant properties. The purpose of this study was to determine the effect of variations in the combination of emulator tween 80 and span 80 on physical quality and stability in naringenin sunscreen preparations, obtain the optimum formula composition from emulsifying agents, and activity of naringenin sunscreen cream preparations in terms of their SPF values. The study used Design Expert 7.1.5 software to design the simplex lattice design method. Each formula was tested for the physical properties of the cream to determine dispersal adhesion for 4 weeks. Naringenin sunscreen cream with a combination of emulsifier tween 80 and span 80 in various concentrations gives a significant difference in the physical quality consisting of the parameters of spreadability, adhesion, and viscosity. The optimum formula for naringenin sunscreen cream obtained the proportion of 9% Tween 80 and 5% span 80. Keywords: Naringenin, Simplex Lattice Design, SPF, Sunscreen.
Co-Authors Anisa Devi Kharisma Wibowo Chong, Rockie Firman Firman Ilham Kuncahyo, Ilham Khairi, Sabiah Lalu Muhammad Irham Ma’ruf, Muhammad Nugraha, Media Fitri Isma Isma Pranata, Satria Puspitaningrum, Anisa Nova Siswanto, Lalu Muhammad Harmain Wirawan Adikusuma Woro Supadmi