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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Nugraha, Media Fitri Isma Isma
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Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Identification of Biomarker for Stunting Through Prioritization of Gene-Assosiated Variants Wibowo, Anisa Devi Kharisma; Puspitaningrum, Anisa Nova; Ma’ruf, Muhammad; Irham, Lalu Muhammad; Supadmi, Woro; Kartikasari, Ayu Lifia Nur; Adikusuma, Wirawan; Chong, Rockie; Firman, Firman; Nugraha, Media Fitri Isma Isma; Siswanto, Lalu Muhammad Harmain; Khairi, Sabiah; Pranata, Satria
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.28297

Abstract

Stunting is a condition of impaired growth and development in children due to chronic nutritional disorders or infections. The risk factor for stunting is dominated by disease during 1000 days of life. The incidence of stunting in Indonesia is 21.6%, according to the Indonesian Nutrition Status Survey (SSGI) results. This study aimed to identify stunting biomarkers based on the priority scoring of gene variants. Identification of stunting risk genes used the Genome-Wide Association Studies (GWAS) approach and Haploreg v4.1. We found 33 genes that identifies as stunting risk gene. And then, we prioritize based on two functional annotation categories: missense-nonsense and cis-expression quantitative trait loci (cis-eQTL). Our analysis found 4 genes as biological stunting risk genes: MTRR, TTF1, CASP1, and CARD17. This research demonstrates the integration of genomic variants and bioinformatics approaches to reveal biological insights for stunting.
Co-Authors Chong, Rockie Firman Firman Kartikasari, Ayu Lifia Nur Khairi, Sabiah Lalu Muhammad Irham Ma’ruf, Muhammad Pranata, Satria Puspitaningrum, Anisa Nova Siswanto, Lalu Muhammad Harmain Wibowo, Anisa Devi Kharisma Wirawan Adikusuma Woro Supadmi