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LITERATURE REVIEW : Cost Effective Analysis of Sitagliptin for the Treatment of Diabetes Mellitus Type 2 Vidiani, Anak Agung Pradnya Paramitha; Puspitaningrum, Anisa Nova; Girsang, Valentina; Adrianto, Madyo
Science and Community Pharmacy Journal Vol. 3 No. 1 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i1.546

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by increased glucose levels in the blood. The prevalence of type 2 DM is currently increasing. In pharmacological treatment, metformin is the first-line oral therapy for most patients with type 2 diabetes. Therapy with targeted incretin has been shown to stimulate glucose-dependent insulin secretion, reduce glucagon secretion, improve beta cell function, slow gastric emptying, increase satiety, reduce appetite, and provide general benefits beyond the pancreas. Search for scientific articles by utilizing internet searches through Google Scholar and PubMed. Using keywords related to "Cost Effective Analysis", "Diabetes Mellitus type 2", "Sitagliptine" with Boolean operator "AND". Sitagliptin is less cost-effective when compared to liraglutide. Sitagliptin is the first agent of the DPP-4 inhibitor with other substances following soon after. The evaluation shows that the prevention of complications in patients with type 2 diabetes and cardiovascular disease (CVD) in the SGLT2 inhibitor group is more recommended, namely empaglifozin as the second line compared to sitagliptin.
A Literature Review: Effectiveness of NSAIDs in Osteoarthritis Patients Adrianto, Madyo; Anak Agung Pradnya Paramitha Vidiani; Puspitaningrum, Anisa Nova; Girsang, Valentina
Science and Community Pharmacy Journal Vol. 3 No. 2 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i2.582

Abstract

Pain, stiffness, swelling, and decreased joint function are some of the clinical signs of osteoarthritis, a disease that affects numerous anatomical and physiological aspects of joint tissue, cartilage degradation, bone remodeling, and osteophyte development. This literature review's objective is to ascertain the efficacy of NSAIDs in osteoarthritis by searching for journals from PubMed.. The method used was to search for articles through pubmed using the keywords "NSAID", "osteoarthritis", "Therapy" with a filter added for the last 5 years (2019-2024) obtained 103 articles. Then with the keywords "NSAID", "osteoarthritis", "therapy", "efficacy" obtained 71 articles. After analysis, there are 13 journals that can be include into inclusion requirement. NSAIDs preparations are particularly helpful for osteoarthritis therapy, both in knee and hip osteoarthritis. NSAIDs medications in a variety of dose forms, including oral, topical, spray, injection and plaster, are useful in relieving pain in osteoarthritis patients
ANALISIS KUALITAS MIKROBIOLOGI KEFIR SUSU KAMBING YANG DIPEROLEH DARI HOME INDUSTRI DIBERGAS KAB . SEMARANG Alfiyaturrakhma, Untsa; Puspitaningrum, Anisa Nova; Dahliyanti, Novita Dwi
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p229-233

Abstract

Kefir is a fermented milk product known for its health benefits, primarily due to its probiotic microorganism content. One type of milk that is increasingly popular for making kefir is goat's milk, as it has a composition that is easier to digest and has high nutritional potential. However, the microbiological quality of goat milk kefir needs to be thoroughly analyzed to ensure its safety and probiotic effectiveness. The presence of microorganisms such as lactic acid bacteria, yeast, and potential pathogenic contaminants plays a crucial role in determining the quality of kefir, both in terms of health benefits and product stability. Therefore, analyzing the microbiological quality of goat milk kefir is essential as a foundation for developing safe, high-quality, and nutritious functional food products. Research Objective : This study aims to analyze the microbiological quality of kefir made from goat’s milk, with a focus on identifying and quantifying the dominant microorganisms involved in the fermentation process, such as lactic acid bacteria and yeast. Research Method: The analysis of microbiological quality was carried out using the Total Plate Count (TPC) method. The counts of bacteria and yeast were conducted in duplicate. The results were then compared to the Indonesian National Standard (SNI) for fermented beverages.
ANALISIS FAKTOR KERENTANAN INDIVIDU TERHADAP INFEKSI FILARIASIS DI DAERAH KURIPAN KERTOHARJO PEKALONGAN SELATAN Nurainy, Farah Destyana; Puspitaningrum, Anisa Nova; Alfiyaturrakhma, Untsa
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p53-59

Abstract

Filariasis is a chronic infectious disease caused by filarial worm infection and transmitted through mosquito bites as a vector. This disease is still a public health problem in several regions in Indonesia, including in Kuripan Kertoharjo Village, South Pekalongan District, which is an endemic area for filariasis. The purpose of this study was to analyze the factors that influence individual susceptibility to filariasis infection in the region. This study used a quantitative design with a cross-sectional approach. The sample consisted of 100 respondents who were selected purposively based on certain criteria such as domicile, age, and exposure history. Data were collected through structured questionnaires, in-depth interviews, and observations of the environmental conditions of the respondents' homes. The variables studied included demographic factors (age, gender, occupation), individual behavior (use of mosquito nets, habits of going out at night), level of knowledge about filariasis, and environmental conditions (sanitation, presence of puddles, housing density). Data analysis was carried out using the chi-square test and logistic regression to determine the relationship and influence of each variable on infection susceptibility. The results showed that low levels of knowledge, the habit of not using mosquito nets, and poor environmental conditions significantly increased the risk of individuals contracting filariasis (p < 0.05). The conclusion of this study is that susceptibility to filariasis is influenced by the interaction between behavioral factors, knowledge, and environmental conditions. Public health interventions that focus on education, behavioral change, and environmental improvement are needed to reduce the rate of filariasis transmission in endemic areas.
Integration of genomic databases and bioinformatic approach to identify genomic variants for sjogren’s syndrome on multiple continents Puspitaningrum, Anisa Nova; Perwitasari, Dyah Aryani; Adikusuma, Wirawan; Djalilah, Gina Noor; Dania, Haafizah; Maliza, Rita; Faridah, Imaniar Noor; Sarasmita, Made Ary; Rezadhini, Melodia; Cheung, Rocky; Irham, Lalu Muhammad
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.23706

Abstract

An autoimmune disorder is an abnormality that causes a disease. It is caused by a weakened immune system. One of the autoimmune diseases is Sjogren’s syndrome, which affects the salivary and lacrimal glands and causes dry mouth, dry eyes, and dry skin. Sjogren’s syndrome influences humans of every age, with the symptoms occurring at the age of 45–55 years and rarely in children. One of the factors causing Sjogren’s syndrome is genetic disorders. To identify genes that can influence Sjogren’s syndrome in this study, we used several databases, including GWAS Catalog, HaploReg Version 4.1, GTEX portal, and Ensembl, particularly to identify the gene expression profiles of TNIP1, TNFAIP3, and IRF5 and the quantitative properties of locus’ expression. This research showed that the missense variants and splice donor rs2233290, rs2230926, and rs2004640 influenced the susceptibility of autoimmune diseases, especially Sjogren’s syndrome, in the fibroblast tissue, sigmoid tissue, sigmoid colon, skin, esophagus, and adrenal glands. The allele frequency of each variant was then assessed in African, American, European, and Asian populations. Our data showed that TNIP1, TNFAIP3, and IRF5 genes in African and American populations had higher frequencies than in the Asian population. This implies that the last of the aforementioned populations might be relatively susceptible to the autoimmune disease Sjogren’s syndrome.
Identification of Biomarker for Stunting Through Prioritization of Gene-Assosiated Variants Wibowo, Anisa Devi Kharisma; Puspitaningrum, Anisa Nova; Ma’ruf, Muhammad; Irham, Lalu Muhammad; Supadmi, Woro; Kartikasari, Ayu Lifia Nur; Adikusuma, Wirawan; Chong, Rockie; Firman, Firman; Nugraha, Media Fitri Isma Isma; Siswanto, Lalu Muhammad Harmain; Khairi, Sabiah; Pranata, Satria
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.28297

Abstract

Stunting is a condition of impaired growth and development in children due to chronic nutritional disorders or infections. The risk factor for stunting is dominated by disease during 1000 days of life. The incidence of stunting in Indonesia is 21.6%, according to the Indonesian Nutrition Status Survey (SSGI) results. This study aimed to identify stunting biomarkers based on the priority scoring of gene variants. Identification of stunting risk genes used the Genome-Wide Association Studies (GWAS) approach and Haploreg v4.1. We found 33 genes that identifies as stunting risk gene. And then, we prioritize based on two functional annotation categories: missense-nonsense and cis-expression quantitative trait loci (cis-eQTL). Our analysis found 4 genes as biological stunting risk genes: MTRR, TTF1, CASP1, and CARD17. This research demonstrates the integration of genomic variants and bioinformatics approaches to reveal biological insights for stunting.
Analisis literasi kesehatan pasien diabetes melitus tipe 2 dengan terapi oral antidiabetes di puskesmas Surabaya Vidiani , Anak Agung Pradnya Paramitha; Puspitaningrum, Anisa Nova
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.413

Abstract

Introduction: Diabetes mellitus (DM) is a chronic disease requiring long-term therapy. Uncontrolled glucose levels can lead to micro and macrovascular complications as well as therapy failure. Medication adherence is a factor influencing the success of DM therapy. The aim of this study is to understand the adherence to oral antidiabetic drugs (OAD). Methods: This research employs a quantitative approach with a non-experimental cross-sectional design. The sample consists of all type 2 DM patients using OAD therapy at Surabaya Community Health Centers who meet the inclusion and exclusion criteria. Results and Conclusion: The health literacy level of Type 2 Diabetes Mellitus Referral Program patients who received Oral Anti-Diabetes therapy at the Surabaya Community Health Center in this study was 45% with high health literacy and 55% with low health literacy with a percentage of 55%. With the domains of patient attitudes towards health (72.50%), patient understanding of health information (57.50%), social support (22.50%), socio-economic considerations (75.00%), accessing health services (92.50%), 50%), communication with health workers (77.50%), pro-active (17.50%), and using health information (80.00%)