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All Journal Majalah Kesehatan Indonesia Journal of Pharmaceutical and Sciences.
Tania, Chyntia Glori
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Potensi Aktivitas Antioksidan dan Antibakteri Ekstrak Etanol Daun Kari (Murraya koenigii) terhadap Propionibacterium acnes Nasri, Nasri; Kaban, Vera Estefania; Rani, Zulmai; Suci, Nurul; Ferendina, Imelda; Tania, Chyntia Glori
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.881

Abstract

Indonesia is renowned for its rich natural resources, particularly medicinal plants with significant therapeutic potential. This study examined how the ethanolic extract of curry leaves (Murraya koenigii) can act as an antioxidant and antibacterial agent against Propionibacterium acnes, the primary cause of acne vulgaris. This study used phytochemical screening to identify secondary metabolites, such as alkaloids, flavonoids, tannins, saponins, and glycosides, which are associated with biological activities such as killing bacteria and protecting cells from damage. The DPPH method for testing antioxidants showed that the extract had an IC50 value of 45.88 mg/L, which is not significantly different from quercetin as a reference, at 23.7 mg/L. This result is still significant for the strong antioxidant category. We assessed antibacterial efficiency using a disc diffusion technique, which showed a zone of inhibition corresponding to the extract concentration. The widest zone of inhibition, measuring 17.77 ± 0.15 mm, was recorded at a concentration of 250 mg/mL, classifying its activity as strong by existing standards. These findings underscore the extract's promise as a natural acne therapy, addressing bacterial growth and oxidative stress. Furthermore, these results support the development of safe and efficacious pharmaceutical or cosmetic products derived from natural components. Future investigations should examine synergistic formulations and enhance bioavailability to optimize therapeutic outcomes.
Texture-Modified Diets and Practical Swallowing Interventions in Head and Neck Cancer Patients with Dysphagia: A Narrative Review Tania, Chyntia Glori; Nasri, Nasri
Majalah Kesehatan Indonesia Vol. 7 No. 1 (2026)
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/makein.2026281

Abstract

Dysphagia is one of the most prevalent and persistent complications in patients with head and neck cancer (HNC), particularly nasopharyngeal carcinoma (NPC), with a reported prevalence of 45–83%. This narrative review aimed to synthesize recent evidence (2015–2025) on the effectiveness of texture-modified diets and swallowing therapies in improving nutritional intake, swallowing safety, and quality of life in HNC patients. Literature searches were performed systematically through PubMed, Scopus, Web of Science, Google Scholar, and Dimensions using predefined inclusion and exclusion criteria, resulting in 12 eligible articles for analysis. The findings showed that dysphagia significantly contributes to malnutrition, aspiration risk, prolonged hospitalization, reduced treatment adherence, and decreased survival. Interventions such as diets guided by the International Dysphagia Diet Standardisation Initiative (IDDSI), personalized nutritional strategies, and structured swallowing therapies demonstrated beneficial outcomes in reducing aspiration, maintaining oral intake, and improving clinical prognosis. In addition to synthesizing clinical outcomes, this review provides a theoretical contribution by framing dysphagia management as a multidisciplinary process that integrates nutritional science, swallowing physiology, and rehabilitative practice. Preventive swallowing exercises during radiotherapy and multidisciplinary management further enhanced long-term outcomes. The synthesis highlights the necessity of integrating nutrition and swallowing rehabilitation into routine oncology practice, with particular implications for healthcare facilities with limited resources where IDDSI adoption and preventive therapy remain underutilized. Future studies should prioritize high-quality randomized controlled trials, particularly in NPC populations, to validate intervention protocols and standardize best practices. This review contributes to bridging evidence with clinical application, providing a framework for safer and more effective patient-centered care.
Co-Authors Ferendina, Imelda Nasri Nasri, Nasri Suci, Nurul Vera Estefania Kaban Zulmai Rani