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All Journal Indonesian Journal of Pharmaceutical and Clinical Research Journal of Pharmaceutical and Sciences.
Suci, Nurul
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Potensi Aktivitas Antioksidan dan Antibakteri Ekstrak Etanol Daun Kari (Murraya koenigii) terhadap Propionibacterium acnes Nasri, Nasri; Kaban, Vera Estefania; Rani, Zulmai; Suci, Nurul; Ferendina, Imelda; Tania, Chyntia Glori
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.881

Abstract

Indonesia is renowned for its rich natural resources, particularly medicinal plants with significant therapeutic potential. This study examined how the ethanolic extract of curry leaves (Murraya koenigii) can act as an antioxidant and antibacterial agent against Propionibacterium acnes, the primary cause of acne vulgaris. This study used phytochemical screening to identify secondary metabolites, such as alkaloids, flavonoids, tannins, saponins, and glycosides, which are associated with biological activities such as killing bacteria and protecting cells from damage. The DPPH method for testing antioxidants showed that the extract had an IC50 value of 45.88 mg/L, which is not significantly different from quercetin as a reference, at 23.7 mg/L. This result is still significant for the strong antioxidant category. We assessed antibacterial efficiency using a disc diffusion technique, which showed a zone of inhibition corresponding to the extract concentration. The widest zone of inhibition, measuring 17.77 ± 0.15 mm, was recorded at a concentration of 250 mg/mL, classifying its activity as strong by existing standards. These findings underscore the extract's promise as a natural acne therapy, addressing bacterial growth and oxidative stress. Furthermore, these results support the development of safe and efficacious pharmaceutical or cosmetic products derived from natural components. Future investigations should examine synergistic formulations and enhance bioavailability to optimize therapeutic outcomes.
Pengaruh gel ekstrak induk kunyit (Curcuma longa linn) terhadap penyembuhan luka sayat pada tikus putih jantan (Rattus norvegicus) Kaban, Vera Estefania; Nasri, Nasri; Rani, Zulmai; Suci, Nurul; Karo Sekali, Elva Swandi; Sagala, Hasel Untung Bersinar
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.590

Abstract

One plant that has been shown to aid wound healing is turmeric. Turmeric has been scientifically proven to have choleretic and anti-inflammatory properties. Turmeric contains curcumin, which has antibacterial and antioxidant qualities that can accelerate the migration and re-epithelialization of cells useful in wound healing, including myofibroblasts, fibroblasts, and macrophages. This study aimed to determine the effect of turmeric mother extract gel on wound healing in male white rats (Rattus norvegicus). This study was conducted using experimental tests. Turmeric extract was prepared using 96% ethanol solvent with a maceration process. A 2 cm long incision wound was made on the back of white rats. The test animals were then divided into five groups to receive different treatments. Groups 3, 4, and 5 received turmeric mother extract gel with concentrations of 1%, 5%, and 10%, while Group 1 was negative control and Group 2 was positive control. The results showed that the incision wounds in male white rats could heal faster - on average, about 7.10 days - when treated with 96% ethanol extract of turmeric mother with doses of 1%, 5%, and 10%. This study concludes that a 10% turmeric mother extract gel is the best method to accelerate wound healing.
Pengembangan Formulasi Krim Pelembab Kulit Berbasis Ekstrak Sari Buah Mangga (Mangifera indica L.): Pendekatan Fungsional dan Kosmetika Alami Suci, Nurul; Khairunnisa, Lia; Nasri, Nasri; Kaban, Vera Estefania
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18220

Abstract

This study aimed to develop a formulation of mango fruit juice (Mangifera indica L.) as a moisturizing agent in the form of hand cream. The main component of mango, sucrose, has the ability to attract moisture from the air due to its hydroxyl groups, which helps reduce water evaporation from the skin. Mango juice was obtained by blending the mango pulp using a juicer, followed by the addition of 0.1% sodium metabisulfite as an antioxidant. The extract was then concentrated using a freeze-drying technique at -40°C and 2 atm pressure. The cream formulation developed was an oil-in-water (m/a) emulsion type, with mango fruit juice concentrations of 2.5%, 5%, 7.5%, and 10%. These were compared to cream containing 2% glycerin and a blank formulation. Various tests were conducted to evaluate the physical quality of the cream, including homogeneity, pH, stability, emulsion type, and irritation tests using a moisture-checker. The results showed that mango fruit juice was successfully formulated into a homogeneous m/a cream, with a pH ranging from 5.55 to 7.04, and remained stable for up to 12 weeks of storage. The cream formulated with mango juice was proven to increase skin moisture without causing irritation. The higher the concentration of mango fruit juice, the greater the moisturizing effect. The 2.5% concentration provided a moisturizing effect comparable to cream containing 2% glycerin. The best moisturizing effect was achieved at a 10% concentration, which increased skin moisture by up to 14.4% after 4 weeks of use. This mango juice is effectively used in m/a type creams as a skin moisturizer. Keyword: Mango fruit juice, cream, skin moisturizer
ANTIOXIDANT ACTIVITY OF HYDROALCOHOLIC EXTRACT OF GREEN GEDI LEAVES (Abelmoschus manihot L.) USING CUPRAC (CUPRIC ION REDUCING ANTIOXIDANT CAPACITY) METHOD Kaban, Vera Estefania; Nasri, Nasri; Suci, Nurul; Lubis, Muhammad Fauzan; Rani, Zulmai; Nasution, Haris Munandar
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 02 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i02.20644

Abstract

Free radicals induce oxidative stress, which plays a pivotal role in the pathogenesis of various degenerative diseases. Abelmoschus manihot L., locally known as green gedi, is recognized for its rich secondary metabolite content with potential antioxidant properties. This study aimed to evaluate the antioxidant activity of the hydroalcoholic extract of green gedi leaves using the Cupric Ion Reducing Antioxidant Capacity (CUPRAC) method. Extraction was conducted via maceration using a 90% hydroalcoholic solvent, followed by comprehensive phytochemical screening and simplicia characterization. The antioxidant capacity was quantified by determining the IC50 value through linear regression analysis of inhibition percentage versus concentration. Phytochemical analysis confirmed the presence of alkaloids, flavonoids, glycosides, saponins, tannins, and triterpenoids/steroids. The hydroalcoholic extract exhibited "very strong" antioxidant activity, yielding an IC50 value of 41.65 ± 0.30 µg/mL. Although this potency was slightly lower than the pure quercetin standard, it demonstrates a significant capacity for free radical neutralization. These findings underscore the potential of Abelmoschus manihot L. as a robust natural antioxidant source, supporting its further development into phytopharmaceuticals or functional health supplements for the prevention of oxidative stress-related conditions.
Co-Authors Ferendina, Imelda Haris Munandar Nasution Karo Sekali, Elva Swandi Khairunnisa, Lia lubis, muhammad fauzan Nasri Nasri, Nasri Sagala, Hasel Untung Bersinar Tania, Chyntia Glori Vera Estefania Kaban Zulmai Rani