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All Journal Indonesian Journal of Pharmaceutical and Clinical Research Indonesian Journal of Applied Research (IJAR) Journal of Pharmaceutical and Sciences.
Suci, Nurul
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Pengaruh gel ekstrak induk kunyit (Curcuma longa linn) terhadap penyembuhan luka sayat pada tikus putih jantan (Rattus norvegicus) Kaban, Vera Estefania; Nasri, Nasri; Rani, Zulmai; Suci, Nurul; Karo Sekali, Elva Swandi; Sagala, Hasel Untung Bersinar
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.590

Abstract

One plant that has been shown to aid wound healing is turmeric. Turmeric has been scientifically proven to have choleretic and anti-inflammatory properties. Turmeric contains curcumin, which has antibacterial and antioxidant qualities that can accelerate the migration and re-epithelialization of cells useful in wound healing, including myofibroblasts, fibroblasts, and macrophages. This study aimed to determine the effect of turmeric mother extract gel on wound healing in male white rats (Rattus norvegicus). This study was conducted using experimental tests. Turmeric extract was prepared using 96% ethanol solvent with a maceration process. A 2 cm long incision wound was made on the back of white rats. The test animals were then divided into five groups to receive different treatments. Groups 3, 4, and 5 received turmeric mother extract gel with concentrations of 1%, 5%, and 10%, while Group 1 was negative control and Group 2 was positive control. The results showed that the incision wounds in male white rats could heal faster - on average, about 7.10 days - when treated with 96% ethanol extract of turmeric mother with doses of 1%, 5%, and 10%. This study concludes that a 10% turmeric mother extract gel is the best method to accelerate wound healing.
Pengembangan Formulasi Krim Pelembab Kulit Berbasis Ekstrak Sari Buah Mangga (Mangifera indica L.): Pendekatan Fungsional dan Kosmetika Alami Suci, Nurul; Khairunnisa, Lia; Nasri, Nasri; Kaban, Vera Estefania
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18220

Abstract

This study aimed to develop a formulation of mango fruit juice (Mangifera indica L.) as a moisturizing agent in the form of hand cream. The main component of mango, sucrose, has the ability to attract moisture from the air due to its hydroxyl groups, which helps reduce water evaporation from the skin. Mango juice was obtained by blending the mango pulp using a juicer, followed by the addition of 0.1% sodium metabisulfite as an antioxidant. The extract was then concentrated using a freeze-drying technique at -40°C and 2 atm pressure. The cream formulation developed was an oil-in-water (m/a) emulsion type, with mango fruit juice concentrations of 2.5%, 5%, 7.5%, and 10%. These were compared to cream containing 2% glycerin and a blank formulation. Various tests were conducted to evaluate the physical quality of the cream, including homogeneity, pH, stability, emulsion type, and irritation tests using a moisture-checker. The results showed that mango fruit juice was successfully formulated into a homogeneous m/a cream, with a pH ranging from 5.55 to 7.04, and remained stable for up to 12 weeks of storage. The cream formulated with mango juice was proven to increase skin moisture without causing irritation. The higher the concentration of mango fruit juice, the greater the moisturizing effect. The 2.5% concentration provided a moisturizing effect comparable to cream containing 2% glycerin. The best moisturizing effect was achieved at a 10% concentration, which increased skin moisture by up to 14.4% after 4 weeks of use. This mango juice is effectively used in m/a type creams as a skin moisturizer. Keyword: Mango fruit juice, cream, skin moisturizer
Docking-Based Evaluation of LC–HRMS Metabolites from Fermented Mustard Greens on DNA Gyrase B and Xanthine Oxidase Nasri; Cintya, Henni; Silalahi, Jansen; Haro, Ginda; Suci, Nurul; Kaban, Vera Estefania
Indonesian Journal of Applied Research (IJAR) Vol. 7 No. 1 (2026): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v7i1.866

Abstract

Fermented mustard greens (Brassica juncea L. Czern.) contain bioactive metabolites formed through lactic acid bacteria–driven biotransformation, yet their molecular targets related to antibacterial and antioxidant functions remain poorly understood. This study aimed to characterize key metabolites in fermented mustard greens and evaluated their potential inhibitory activity against DNA gyrase B and Xanthine Oxidase through an integrated LC–HRMS metabolomics and molecular docking approach. Untargeted LC–HRMS profiling identified 292 metabolite features, from which five compounds—gentisic acid, trans-cinnamic acid, xanthurenic acid, indole-3-lactic acid, and indole-3-acrylic acid—were structurally confirmed via MS/MS fragmentation. These metabolites were docked against DNA gyrase B (5D7R) and Xanthine Oxidase (3NVW) to predict binding affinity and interaction mechanisms. Xanthurenic acid exhibited the strongest interaction with DNA gyrase B (–7.6 kcal/mol), forming hydrogen bonds with key catalytic residues, such as Asp81 and Ile86, which suggested ATP-competitive inhibition. Meanwhile, gentisic acid and indole-3-acrylic acid exhibited the most favorable binding to Xanthine Oxidase (–7.2 kcal/mol), characterized by π–π stacking with Phe914 and Phe1009 and hydrogen bonding to Glu802, indicating dual antioxidant and anti-hyperuricemic potential. These findings highlighted fermented mustard greens as a promising functional food source containing metabolites with predicted antibacterial and XO-inhibitory activities. Further in vitro and in vivo validation is required to confirm these computational insights.
Co-Authors Cintya, Henni Haro, Ginda Jansen Silalahi Karo Sekali, Elva Swandi Khairunnisa, Lia Nasri Nasri Nasri, Nasri Sagala, Hasel Untung Bersinar Vera Estefania Kaban Zulmai Rani