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All Journal INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY
Pratiwi, Hanum Adisty
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Health Professions Social Sciences

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Potential of ethanolic extracts from seed kernel Indonesian cultivars mangoes as an anti-multidrug-resistant (MDR) Escherichia coli Ariyadi, Tulus; Qayimah, Sitti; Assa’diyah, Lulu’ Nur; Asyiah, Asyiah; Pratiwi, Hanum Adisty; Khairunnisa, Afifah; Hikmah, Annisa Nurul; Kusmita, Lia; Mutmainah, Mutmainah; Mukaromah, Ana Hidayati
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i2.5837

Abstract

Escherichia coli is a type of bacteria that often found in wound infections. The use of antibiotics to treat these uncontrolled infections has resulted in the emergence of multi-drug resistant (MDR) strains of pathogenic bacteria.  This rapid increase in MDR E. coli strains has led to significant morbidity and mortality in human populations. Consequently, the exploration of natural antibacterial agents is urgently needed. One promising resource is mango extract, which is recognised for its antibacterial properties and is obtained through solvent extraction using 96% ethanol. This study aimed to determine the antibacterial activity of seed extracts from seven different mango cultivars (Mangifera indica L.), against MDR E. coli. The study focused on determining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) using dilution method. The concentrations examined for both MIC and MBC were 5, 10, 50, and 100 mg/mL. The results indicate that the mango seed extract exhibit significant antibacterial activity against MDR-E. coli., with the kweni cultivar showing the largest inhibition zone measuring 23.25 mm. The ethanol extract from the kweni seeds yielded the most favorable results, with an MIC value of ≥0.078 mg/mL and an MBC value that ranged from 1.25-10 mg/mL. In conclusion, mango seed extract, particularly from the kweni cultivar, has substantial potential to be developed as an effective antibacterial agent against MDR-E. coli.
Co-Authors Ana Hidayati Mukaromah Assa’diyah, Lulu’ Nur Asyiah, Asyiah Hikmah, Annisa Nurul Khairunnisa, Afifah Lia Kusmita Mutmainah Mutmainah Qayimah, Sitti Tulus Ariyadi