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All Journal Jurnal Biologi Tropis
Ningsih, Nur Aulia Ahya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Understanding Lung Abscess: Clinical Manifestations, Diagnosis, and Management Hadinata, Lalu Gde Gilang Alid; Angelita, Puja Rizkina; Lativa, Nindy Citra; Ningsih, Nur Aulia Ahya
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10457

Abstract

Lung abscess is a pulmonary condition characterized by a localized collection of pus within lung tissue, usually caused by bacterial infection. It often occurs as a complication of pneumonia, aspiration, or in individuals with weakened immune systems. This literature review aims to discuss the definition, etiology, epidemiology, clinical manifestations, diagnosis, management, and prognosis of lung abscess to provide a better understanding of this disease and its optimal treatment approach. The review was conducted based on recent literature and clinical guidelines related to lung abscess, including national and international sources such as the Indonesian Society of Pulmonologists (PDPI), WHO reports, and recent journal publications. Lung abscess is primarily caused by anaerobic bacteria and Staphylococcus aureus. The main clinical features include fever, productive cough with foul-smelling sputum, chest pain, and shortness of breath. Diagnosis is established through clinical examination, sputum analysis, and radiological imaging such as chest X-ray or CT scan. The main treatment involves antibiotic therapy, followed by drainage or surgical procedures if no improvement occurs. Prognosis depends on early diagnosis and appropriate antibiotic use, with mortality rates ranging from 10–20%. Early recognition and proper management of lung abscess are essential to prevent complications such as empyema or bronchopleural fistula. Rational antibiotic use and supportive care remain the cornerstone of therapy, while surgical intervention is reserved for refractory cases.
Immunobiology and Molecular Approaches to Myasthenic Crisis in the Context of Tropical Biology Ningsih, Nur Aulia Ahya; Rifki, Muhammad; Firdaus, Nadine Aisyah Sultan; Latifa, Nindy Citra; Fathana, Prima Belia
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10513

Abstract

Myasthenic crisis is a severe acute complication of myasthenia gravis (MG) characterized by respiratory and bulbar muscle insufficiency due to impaired neuromuscular transmission, with pathogenesis involving autoantibodies targeting acetylcholine receptors (AChR), muscle-specific kinase (MuSK), and low-density lipoprotein receptor-related protein 4 (LPR4) that disrupt the integrity of the neuromuscular junction. This review aims to examine the immunobiological mechanisms of myasthenic crisis and explore the potential of modern biotechnological therapies and tropical bioactive compounds as adaptive treatment strategies for tropical populations. A comprehensive literature review was conducted focusing on genetic factors, tropical environmental influences, and advancements in molecular therapies. Genetic factors, including HLA class II and non-HLA genes, interact with tropical environmental conditions such as endemic infections, high temperature, extreme humidity, air pollution, and vitamin D deficiency, potentially exacerbating immune dysregulation and increasing crisis risk. Modern molecular therapies, including rituximab (anti-CD20), eculizumab (anti-C5), and efgartigimod (FcRn inhibitor), have demonstrated efficacy in reducing pathogenic autoantibodies and improving neuromuscular function, while tropical bioactive compounds such as curcumin and andrographolide show potential as adjuvant immunomodulators. Integrating biotechnological approaches with tropical bioprospecting provides a more adaptive and sustainable therapeutic strategy aligned with the biological characteristics of tropical populations. It is recommended that further clinical studies evaluate the safety, optimal dosing, and long-term efficacy of combined biotechnological and bioactive therapies in these populations.
Co-Authors Angelita, Puja Rizkina Firdaus, Nadine Aisyah Sultan Hadinata, Lalu Gde Gilang Alid Latifa, Nindy Citra Lativa, Nindy Citra Muhammad Rifki Prima Belia Fathana