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Hadinata, Lalu Gde Gilang Alid
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Giant Cell Tumor of Bone, Tendon, and Soft Tissue: Pathogenesis and Clinical Manifestations Yulianti, Arwinda Febri; Paerdoe, Lalu Dane Pemban; Hidayat, Rahmat; Qindi, Ahmad Sa`bi Al; Hadinata, Lalu Gde Gilang Alid; Widad, Najwa; Febianisa, Tabitha Afifah; Pramesti, Evane Dyahayu; Khairifathiyyah, Khairifathiyyah; Amalia, Azka; Purnaning, Dyah
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10350

Abstract

Giant Cell Tumor (GCT) is a primary neoplasm that is intermediate malignant, characterized by aggressive local growth and the possibility of metastasis, especially to the lungs. Giant Cell Tumor (GCT) occurs in bones, tendons, and soft tissues. The purpose of this literature study is to identify differences in GCT manifestations in various anatomical locations, evaluate risk factors that contribute to tumor growth and recurrence, and assess the effectiveness of various therapeutic modalities that have been used, both conservative and operative. The method used is a literature study by reviewing various scientific journals obtained from the database. The findings show that Giant Cell Tumor (GCT) is a group of neoplasms that are histologically similar but have different clinical, molecular characteristics, and anatomical locations, including GCT in bones (GCTB), tendons (GCTTS), and soft tissues (GCTST). Although generally classified as benign, GCT can be locally aggressive with a risk of recurrence and in some cases is capable of metastasis, especially to the lungs. GCTB is most commonly found in the long bones of individuals aged 20–40 years and is characterized by the H3F3A mutation, which is an important diagnostic marker. GCTTS, which originates in the synovium, is more common in women aged 30–50 years and shows increased CSF1 expression due to a genetic translocation.
Vaccine Administration Risk in Guillain-Barré Syndrome: A Systematic Review Febianisa, Tabitha Afifah; Hadinata, Lalu Gde Gilang Alid; Hunaifi, Ilsa; Amalia, Azka
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10361

Abstract

Guillain-Barré syndrome (GBS) is a disorder in which the body's immune system attacks the peripheral nervous system due to molecular mimicry, characterized by progressive muscle weakness from distal to proximal. This systematic review examines the relationship between vaccination and the risk of GBS. Epidemiological data indicate that the incidence of GBS after vaccination is very low. Although there is a link between vaccination and GBS in some cases, the risk remains smaller than the risk of GBS due to natural infection with the pathogen. This study emphasizes that the benefits of vaccination in preventing infection outweigh the risk of vaccination causing GBS. Guillain-Barré syndrome (GBS) is a disorder in which the body's immune system attacks the peripheral nervous system due to molecular mimicry, causing muscle weakness that progresses rapidly to paralysis. From this literature review, it can be concluded that the risk of GBS after vaccination is very low and is limited to certain vaccines. Furthermore, GBS cases occur more frequently after viral or bacterial infections than after vaccination, indicating that the benefits of vaccination in preventing infectious diseases far outweigh the risk of causing GBS.
Understanding Lung Abscess: Clinical Manifestations, Diagnosis, and Management Hadinata, Lalu Gde Gilang Alid; Angelita, Puja Rizkina; Lativa, Nindy Citra; Ningsih, Nur Aulia Ahya
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10457

Abstract

Lung abscess is a pulmonary condition characterized by a localized collection of pus within lung tissue, usually caused by bacterial infection. It often occurs as a complication of pneumonia, aspiration, or in individuals with weakened immune systems. This literature review aims to discuss the definition, etiology, epidemiology, clinical manifestations, diagnosis, management, and prognosis of lung abscess to provide a better understanding of this disease and its optimal treatment approach. The review was conducted based on recent literature and clinical guidelines related to lung abscess, including national and international sources such as the Indonesian Society of Pulmonologists (PDPI), WHO reports, and recent journal publications. Lung abscess is primarily caused by anaerobic bacteria and Staphylococcus aureus. The main clinical features include fever, productive cough with foul-smelling sputum, chest pain, and shortness of breath. Diagnosis is established through clinical examination, sputum analysis, and radiological imaging such as chest X-ray or CT scan. The main treatment involves antibiotic therapy, followed by drainage or surgical procedures if no improvement occurs. Prognosis depends on early diagnosis and appropriate antibiotic use, with mortality rates ranging from 10–20%. Early recognition and proper management of lung abscess are essential to prevent complications such as empyema or bronchopleural fistula. Rational antibiotic use and supportive care remain the cornerstone of therapy, while surgical intervention is reserved for refractory cases.
Co-Authors Amalia, Azka Angelita, Puja Rizkina Febianisa, Tabitha Afifah Ilsa Hunaifi, Ilsa Khairifathiyyah, Khairifathiyyah Lativa, Nindy Citra Ningsih, Nur Aulia Ahya Paerdoe, Lalu Dane Pemban Pramesti, Evane Dyahayu Purnaning, Dyah Qindi, Ahmad Sa`bi Al Rahmat Hidayat Widad, Najwa Yulianti, Arwinda Febri