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All Journal Jurnal Biologi Tropis Mandala of Health : A Scientific Journal
Latifa, Nindy Citra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health

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Association Between Posyandu’s Role in Maternal Nutrition Monitoring and Stunting in Puyung Latifa, Nindy Citra; Nurbaiti, Lina; Hasby, Amelia Ramdani
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10304

Abstract

Stunting is a health issue, particularly in poor nations such as Indonesia. One factor that contributes to stunting is mothers' nutritional status during pregnancy. Integrated Health Posts (Posyandu) monitor pregnant women's nutritional status by assessing mid-upper arm circumference (LILA), hemoglobin (Hb) levels, and maternal compliance with iron supplementation (TTD). The purpose of this study is to examine the association between Posyandu's role in monitoring pregnant women's nutritional status and the prevalence of stunting at the Puyung Community Health Center in Central Lombok Regency. This is an analytical correlation study conducted in a cross-sectional design. The sampling method was stratified random sampling. Data was collected using the KIA Handbook and questionnaires. The chi-square test was utilized while analyzing bivariate data. Of the 90 responders, 8 (8.9%) had low nutritional status during pregnancy, and 49 (54.4%) had stunted toddlers at the Puyung Community Health Center in Central Lombok. The bivariate test using the chi-square method yielded a p-value of 0.791 (p > 0.05), indicating that there is no significant relationship between maternal nutritional status during pregnancy and the incidence of stunting in the working area of Puyung Health Center, Central Lombok Regency. The study concludes that there is no significant association between the involvement of integrated health posts (Posyandu) in monitoring maternal nutritional status during pregnancy and the prevalence of stunting in Puyung Health Center's operational area, Central Lombok Regency.
PROTECTIVE ROLE OF HUMAN BREAST MILK AGAINST NECROTIZING ENTEROCOLITIS IN PRETERM INFANTS Putri, Dyah Arista; Patandianan, Firdaus Kamma; Latifa, Nindy Citra; Ramadhania, Yasmin Najla; Rofilah, Alita Khainur; Maharani, Baiq Syarifaturrayyan; Yassa, I Wayan Radityakara Wirasena; Arigi, Lalu Ahmad Gamal
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17753

Abstract

Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disease that predominantly affects preterm infants, with high rates of morbidity and mortality. Human breast milk (HBM) has long been recognized as the most effective nutritional intervention for preventing NEC due to its unique bioactive components such as immunoglobulins, lactoferrin, glutamine, vitamins, and human milk oligosaccharides (HMOs), which act through mechanisms including strengthening the intestinal barrier, modulating immune responses, and regulating the gut microbiota. This narrative review aims to synthesize recent evidence on the protective role of HBM against NEC, with particular emphasis on the function of HMOs, probiotics, and complementary nutritional interventions designed to replicate or enhance HBM’s bioactivity. The methods applied in this review followed a narrative literature search in PubMed, Scopus, and Google Scholar for studies published between 2015 and 2025 on the effects of breastfeeding on NEC risk in preterm infants, using predefined eligibility criteria. The findings indicate that HBM significantly reduces NEC incidence, while supplemental interventions such as prebiotics and probiotics may serve as complementary strategies, particularly when the availability of mother’s own milk is limited. Overall, HBM remains the primary protective factor against NEC, and optimizing its provision in neonatal care is critical for improving outcomes among preterm infants.
Immunobiology and Molecular Approaches to Myasthenic Crisis in the Context of Tropical Biology Ningsih, Nur Aulia Ahya; Rifki, Muhammad; Firdaus, Nadine Aisyah Sultan; Latifa, Nindy Citra; Fathana, Prima Belia
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10513

Abstract

Myasthenic crisis is a severe acute complication of myasthenia gravis (MG) characterized by respiratory and bulbar muscle insufficiency due to impaired neuromuscular transmission, with pathogenesis involving autoantibodies targeting acetylcholine receptors (AChR), muscle-specific kinase (MuSK), and low-density lipoprotein receptor-related protein 4 (LPR4) that disrupt the integrity of the neuromuscular junction. This review aims to examine the immunobiological mechanisms of myasthenic crisis and explore the potential of modern biotechnological therapies and tropical bioactive compounds as adaptive treatment strategies for tropical populations. A comprehensive literature review was conducted focusing on genetic factors, tropical environmental influences, and advancements in molecular therapies. Genetic factors, including HLA class II and non-HLA genes, interact with tropical environmental conditions such as endemic infections, high temperature, extreme humidity, air pollution, and vitamin D deficiency, potentially exacerbating immune dysregulation and increasing crisis risk. Modern molecular therapies, including rituximab (anti-CD20), eculizumab (anti-C5), and efgartigimod (FcRn inhibitor), have demonstrated efficacy in reducing pathogenic autoantibodies and improving neuromuscular function, while tropical bioactive compounds such as curcumin and andrographolide show potential as adjuvant immunomodulators. Integrating biotechnological approaches with tropical bioprospecting provides a more adaptive and sustainable therapeutic strategy aligned with the biological characteristics of tropical populations. It is recommended that further clinical studies evaluate the safety, optimal dosing, and long-term efficacy of combined biotechnological and bioactive therapies in these populations.
Co-Authors Arigi, Lalu Ahmad Gamal Firdaus, Nadine Aisyah Sultan Hasby, Amelia Ramdani Lina Nurbaiti, Lina Maharani, Baiq Syarifaturrayyan Muhammad Rifki Ningsih, Nur Aulia Ahya Patandianan, Firdaus Kamma Prima Belia Fathana Putri, Dyah Arista Ramadhania, Yasmin Najla Rofilah, Alita Khainur Yassa, I Wayan Radityakara Wirasena