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All Journal Jurnal Penelitian Farmasi dan Herbal
Br Sembiring, Tio Ranti Sari
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Medicine & Pharmacology

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FORMULASI DAN UJI AKTIVITAS SEDIAAN GEL ANTIACNE EKSTRAK ETANOL DAGING KURMA (Pheonix dactylifera L.) TERHADAP BAKTERI Propionibacterium acnes & Pseudomonas aeruginosa Marbun, Nova rianti; Br Sembiring, Tio Ranti Sari
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2710

Abstract

Acne (acne vulgaris) is a skin inflammation caused by the overgrowth of bacteria such as Propionibacterium acnes and Pseudomonas aeruginosa. This study aims to formulate a gel preparation containing ethanol extract of date flesh and evaluate its antibacterial activity. The extract was obtained via maceration using 70% ethanol. The gel was formulated in three extract concentrations: 10%, 20%, and 30%. Physical evaluations of the gel included organoleptic properties, homogeneity, pH, spreadability, and adhesiveness, while antibacterial activity was tested using the disk diffusion method. The results showed that the 30% concentration provided the largest inhibition zone against both test bacteria. Physical evaluations confirmed that the gel preparation met the criteria for a stable topical product. It can be concluded that the ethanol extract of date flesh can be effectively formulated into an antibacterial gel preparation and has potential as a natural antiacne product.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BONGGOL BROKOLI (Brassica oleracea L. var. Italica) DENGAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazy) Umaya, Chindy; Marbun, Nova Rianti; Br Sembiring, Tio Ranti Sari
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2732

Abstract

Broccoli (Brassica oleracea L. var. Italica) is a vegetable recognized for its abundant bioactive components, such as flavonoids, tannins, saponins, and vitamin C, which are linked to antioxidant capabilities. Notwithstanding its health advantages, the broccoli stalk is frequently disregarded and underexploited, despite its potential as a source of natural antioxidant chemicals. This work aims to assess the antioxidant activity of the ethanolic extract from broccoli stalks utilizing the DPPH method and to ascertain its IC₅₀ value. The extraction was conducted via the maceration method utilizing 70% ethanol, and the antioxidant activity was assessed through UV-Vis spectrophotometry at a peak wavelength of 516 nm. The results indicated that the ethanolic extract of broccoli stem possesses considerable antioxidant activity, with an IC₅₀ value of 35.74 µg/ml. The IC₅₀ value of vitamin C was shown to be 7.67 µg/ml. The results indicate that broccoli stalks may be a significant source of natural antioxidants. The validation of the analytical method demonstrated outstanding results, including linearity (r = 0.9989), accuracy (100.57%), and precision (%RSD = 0.5646%).
Co-Authors Marbun, Nova rianti Umaya, Chindy