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All Journal JURNAL FARMASIMED (JFM) Jurnal Surya
Elasari Dwi Pratiwi
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Health Professions Medicine & Pharmacology Nursing Public Health

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Article Review: In Vitro, In Vivo, And Clinical Trial Data on Proanthocyanidin Compounds Cici Sayyidatul Adhimi; Aditya Sindu Sakti; Elasari Dwi Pratiwi; Khan, Muhammad Adil
Jurnal Surya Vol 16 No 2 (2024): VOL 16 NO 02 AUGUST 2024
Publisher : Universitas Muhammadiyah Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38040/js.v16i2.1011

Abstract

Proanthocyanidins, also known as condensed tannins, are oligomeric flavonoids found in various plants such as seeds, fruits, and leaves, and they offer health benefits. In vitro, in vivo, and clinical trials can demonstrate and confirm the appropriate dosage for their development in the health sector. The aim of this review article is to provide a systematic overview of the health benefits of proanthocyanidin compounds. The review process was conducted online using websites such as Google Scholar, NCBI, ScienceDirect, NIH, and PubMed with the keywords “in vitro, in vivo, and clinical trials of proanthocyanidin compounds”. The review results indicate that in vitro, in vivo, and clinical studies on proanthocyanidin compounds show health benefits such as antidiabetic, antioxidant, antibacterial, immunostimulant, insomnia therapy, analgesic effects, anthelmintic agents, and potential for COVID-19 prevention and treatment.
Comparison of Continuous Percolation and Ultrasound-Assisted Extraction (UAE) Methods on Total Phenolic Content of 70% Ethanol Extract of Purslane (Portulaca oleracea L.) Aditya Sindu Sakti; Fransisca Dita Mayangsari; Sri Bintang Sahara Mahaputra Kusuma Negara; Elasari Dwi Pratiwi; Sandrawati
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/dxzsgc71

Abstract

Background: Portulaca oleracea L., commonly known as Krokot, is rich in phenolic compounds with notable pharmacological benefits. Optimizing extraction methods is critical to maximize its bioactive potential. Objective: This study aimed to compare the efficiency of Continuous Percolation (CP) and Ultrasound-Assisted Extraction (UAE) in obtaining total phenolic content (TPC) from 70% ethanol extract of P. oleracea. Methods: Dried powdered P. oleracea was subjected to CP and UAE using a 1:10 (w/v) plant-to-solvent ratio. Qualitative screening with FeCl₃ confirmed the presence of phenolics. TPC was quantified using the Folin–Ciocalteu method, expressed as mg gallic acid equivalent (GAE)/g extract. Statistical analysis included normality testing, Levene’s test, and the Mann–Whitney U test. Results: UAE yielded significantly higher TPC (420.04 ± 0.40 mg GAE/g) compared to CP (354.30 ± 0.00 mg GAE/g; p = 0.034), although CP produced a higher extract mass. Statistical results confirmed the superiority of UAE in selectively extracting phenolic constituents. Conclusion: UAE is more effective than CP in extracting phenolic compounds from P. oleracea, likely due to enhanced cavitation-induced mass transfer. This method is recommended for maximizing phenolic recovery in plant-based extractions, especially for thermolabile compounds.
Co-Authors Aditya Sindu Sakti Cici Sayyidatul Adhimi Fransisca Dita Mayangsari Khan, Muhammad Adil Sandrawati Sri Bintang Sahara Mahaputra Kusuma Negara