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All Journal JURNAL FARMASIMED (JFM) Jurnal Surya NUSANTARA: Jurnal Pengabdian Kepada Masyarakat Journal of Clinical Pharmacy and Pharmaceutical Science
Aditya Sindu Sakti
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Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Narrative Review of Anti-Retrovirals Used in COVID-19 Treatment Aditya Sindu Sakti; Irma Susanti; Djati Wulan Kusumo
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 3 No. 2 (2024): Oktober : Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v3i2.54

Abstract

The COVID-19 pandemic has necessitated the exploration of various therapeutic strategies, including the repurposing of existing antiviral drugs. This narrative review examines the use of anti-retroviral agents in the treatment of COVID-19, focusing on their mechanisms of action, efficacy, and safety profiles. Key antiretrovirals discussed include Remdesivir, Lopinavir/Ritonavir, Ribavirin, Oseltamivir, Favipiravir, and Sofosbuvir. These agents primarily act by inhibiting RNA-dependent RNA polymerase (RdRp), a critical enzyme in the replication cycle of SARS-CoV-2. Clinical trials and in vitro studies have provided mixed results regarding their effectiveness, with some agents showing promise in reducing mortality and improving recovery times, while others have demonstrated limited efficacy. The review highlights the urgent need for further clinical research to optimize antiviral regimens and improve patient outcomes in the ongoing battle against COVID-19.
Peningkatan Literasi Penggunaan Obat melalui Edukasi Pengenalan Logo Obat bagi Siswa SMP Muhammadiyah 04 Pangkatrejo Aditya Sindu Sakti; Bheta Sari Dewi; Nurul Izzah H. L. Pasi; Marhamah Marhamah; Amalia Puspa Wahyu; Deta Hilar Nurrohmah; M. Ahsanul Farihin; Nur’aini Al Wahida
Nusantara: Jurnal Pengabdian kepada Masyarakat Vol. 5 No. 4 (2025): November: NUSANTARA Jurnal Pengabdian Kepada Masyarakat
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/nusantara.v5i4.6982

Abstract

This community service program aimed to enhance students’ pharmaceutical literacy through the introduction of drug classification logos at SMP Muhammadiyah 04 Pangkatrejo. The background of this activity was the low level of drug-use literacy among adolescents, often leading to irrational self-medication. The activity employed a quantitative descriptive design with a one-group pretest–posttest approach. Educational interventions included interactive counseling, PowerPoint presentations, visual media using logo sticks, and pretest–posttest evaluation. Data were analyzed using the Wilcoxon Signed Rank Test. The results showed a significant improvement in students’ knowledge (p = 0.000), with mean scores increasing from 58% to 81% after the intervention. The highest gain was observed in the recognition of logo colors and drug classifications. Satisfaction analysis revealed that 96% of participants expressed satisfaction with the learning process, especially regarding material clarity and the presenters’ readiness to answer questions. The study concludes that participatory educational methods and visual media effectively improve rational drug-use awareness among junior high school students. Future programs are recommended to expand similar activities to other schools and integrate digital media for sustained impact on public health literacy.
Article Review: In Vitro, In Vivo, And Clinical Trial Data on Proanthocyanidin Compounds Cici Sayyidatul Adhimi; Aditya Sindu Sakti; Elasari Dwi Pratiwi; Khan, Muhammad Adil
Jurnal Surya Vol 16 No 2 (2024): VOL 16 NO 02 AUGUST 2024
Publisher : Universitas Muhammadiyah Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38040/js.v16i2.1011

Abstract

Proanthocyanidins, also known as condensed tannins, are oligomeric flavonoids found in various plants such as seeds, fruits, and leaves, and they offer health benefits. In vitro, in vivo, and clinical trials can demonstrate and confirm the appropriate dosage for their development in the health sector. The aim of this review article is to provide a systematic overview of the health benefits of proanthocyanidin compounds. The review process was conducted online using websites such as Google Scholar, NCBI, ScienceDirect, NIH, and PubMed with the keywords “in vitro, in vivo, and clinical trials of proanthocyanidin compounds”. The review results indicate that in vitro, in vivo, and clinical studies on proanthocyanidin compounds show health benefits such as antidiabetic, antioxidant, antibacterial, immunostimulant, insomnia therapy, analgesic effects, anthelmintic agents, and potential for COVID-19 prevention and treatment.
Comparison of Continuous Percolation and Ultrasound-Assisted Extraction (UAE) Methods on Total Phenolic Content of 70% Ethanol Extract of Purslane (Portulaca oleracea L.) Aditya Sindu Sakti; Fransisca Dita Mayangsari; Sri Bintang Sahara Mahaputra Kusuma Negara; Elasari Dwi Pratiwi; Sandrawati
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/dxzsgc71

Abstract

Background: Portulaca oleracea L., commonly known as Krokot, is rich in phenolic compounds with notable pharmacological benefits. Optimizing extraction methods is critical to maximize its bioactive potential. Objective: This study aimed to compare the efficiency of Continuous Percolation (CP) and Ultrasound-Assisted Extraction (UAE) in obtaining total phenolic content (TPC) from 70% ethanol extract of P. oleracea. Methods: Dried powdered P. oleracea was subjected to CP and UAE using a 1:10 (w/v) plant-to-solvent ratio. Qualitative screening with FeCl₃ confirmed the presence of phenolics. TPC was quantified using the Folin–Ciocalteu method, expressed as mg gallic acid equivalent (GAE)/g extract. Statistical analysis included normality testing, Levene’s test, and the Mann–Whitney U test. Results: UAE yielded significantly higher TPC (420.04 ± 0.40 mg GAE/g) compared to CP (354.30 ± 0.00 mg GAE/g; p = 0.034), although CP produced a higher extract mass. Statistical results confirmed the superiority of UAE in selectively extracting phenolic constituents. Conclusion: UAE is more effective than CP in extracting phenolic compounds from P. oleracea, likely due to enhanced cavitation-induced mass transfer. This method is recommended for maximizing phenolic recovery in plant-based extractions, especially for thermolabile compounds.
Nanostructured Lipid Carrier (NLC) Based Gel as Patchouli Oil Delivery : Physical Characteristic and In Vivo Skin Irritation Test Mayangsari, Fransisca Dita; Aditya Sindu Sakti; Merry Anggelya Mentari
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/vc33d509

Abstract

Patchouli oil (PO) contained patchoulol, which has antioxidant activity, making it a valuable ingredient in anti-aging products. However, this oil is volatile and chemically unstable. Therefore, it needs to be formulated into a Nanostructured Lipid Carriers based gel (NBG). This study aims to observe the effect of PO’s concentration on the physical characteristics and skin irritation of NBG preparations. NBG consists of 50% NLC and 50% gel. There are three formulas observed in this study, namely NBG-0 (0% PO), NBG-2 (2% PO), NBG-4 (4% PO). NLC prepared using the High Shear Homogenization method. Based on the physical characteristics test, it is known that all formulas have differences in the aroma aspect, where NBG-0 odorless, while NBG-2 and NBG-4 have a patchouli scent. All formula do not have differences in color and consistency. All formula have a pH in the range of 5.92 - 6.21. Statistically, increasing the concentration of PO decreases the pH of NBG. The three formulas have a viscosity in the range of 4.493 - 9.880 cP. Statistically, viscosity of NBG increasased by increasing concentration of PO. Based on in vivo skin irritation tests using white mice, it is known that all formulas have the same IIP (Primary Irritation Index) value. Based on the study, it can be concluded that the concentration of PO (0%, 2%, 4%) affects the aroma, pH and viscosity aspects but does not affect the color and consistency of NBG. Increasing the PO concentration in NBG up to 4% did not cause skin irritation.
Co-Authors Amalia Puspa Wahyu Bheta Sari Dewi Cici Sayyidatul Adhimi Deta Hilar Nurrohmah Elasari Dwi Pratiwi Fransisca Dita Mayangsari Irma Susanti Khan, Muhammad Adil Kusumo, Djati Wulan M. Ahsanul Farihin Marhamah Marhamah Merry Anggelya Mentari Nurul Izzah H. L. Pasi Nur’aini Al Wahida Sandrawati Sri Bintang Sahara Mahaputra Kusuma Negara