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All Journal Indonesian Journal of Global Health research Jurnal Vokasi Kesehatan
Randenia, Nabila
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Role of Phenolic Compounds as Anti-Inflammatory in Obese Individuals Randenia, Nabila; Noer, Etika Ratna; Anjani, Gemala
Indonesian Journal of Global Health Research Vol 6 No 2 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i2.2682

Abstract

Dietary polyphenols have chemopreventive and protective roles in maintaining human health and disease. Strong antioxidant effects are exhibited by dietary polyphenols and flavonoids against reactive oxygen species (ROS) and cellular oxidative stress (OS), thereby protecting against OS-related pathological conditions or diseases. This study generally aims to see the impact of phenol and bioactive compounds on inflammation in obese individuals. The method used in this study is a literature review. The stages involved in this process encompass identifying the central topic or issue to be discussed, conducting a comprehensive search for pertinent references or literature related to the topic, thoroughly reading, evaluating, and analyzing the literature in alignment with the study objectives, and finally, composing a narrative report that presents the review findings along with a concise summary. The time frame for the analysis was April 2013 to June 2023. A total of 323 publications with phenolic compounds as anti-inflammatory in obese were identified. From the initial 323 studies, 12 studies were selected for final analysis. The search for relevant articles or references will be conducted in the online databases Science Direct, Springer, Wiley Library, PubMed, and Google Scholar. The keywords used to search for references are obesity, inflammation, phenol compounds, bioactive compounds, antioxidants, and antioxidants. This literature review found that out of the 12 articles reviewed, 12 had similarities, stating that interventions with different doses of phenol compounds can reduce inflammatory cytokines in obesity with different periods. Overall, antioxidant bioactive compounds regulate pro-inflammatory and anti-inflammatory cytokines, reduce oxidative stress by decreasing the accumulation of reactive oxygen species, and enhance antioxidant capacity and gene expression to prevent DNA damage in obese individuals.
Analisis Multidimensional Faktor Penyebab Stunting di Indonesia: Literature Review Stefany, Fadean; Nawai, Fatmayanti; Mahabatillah, Desty; Randenia, Nabila
Jurnal Vokasi Kesehatan Vol 4 No 2 (2025)
Publisher : Gayaku Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/juvokes.v4i2.1711

Abstract

Stunting merupakan permasalahan gizi kronis yang masih menjadi tantangan serius bagi pembangunan sumber daya manusia di Indonesia. Kondisi ini mencerminkan gangguan pertumbuhan yang disebabkan oleh interaksi kompleks antara faktor biologis, sosial ekonomi, lingkungan, pendidikan, dan budaya. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis faktor-faktor utama penyebab stunting melalui pendekatan systematic literature review berdasarkan pedoman PRISMA. Sumber data diperoleh dari 20 artikel nasional dan internasional yang diterbitkan pada periode 2018–2025 melalui basis data Google Scholar, PubMed, ScienceDirect, dan Garuda. Hasil analisis menunjukkan bahwa determinan utama stunting meliputi status gizi ibu hamil, praktik pemberian ASI dan MPASI, tingkat pendidikan dan pendapatan keluarga, kondisi sanitasi lingkungan, faktor sosial budaya dan kesehatan mental ibu, serta kecukupan asupan zat gizi makro dan mikro. Selain itu, inovasi teknologi seperti pemodelan K-Means Clustering berpotensi membantu pemerintah dalam mengidentifikasi kelompok berisiko tinggi dan merancang kebijakan berbasis data yang lebih tepat sasaran. Kesimpulannya, pencegahan stunting memerlukan pendekatan lintas sektor yang komprehensif dengan mengintegrasikan aspek gizi, kesehatan, pendidikan, ekonomi, lingkungan, dan kebijakan publik. Pendekatan ini diharapkan dapat mendukung percepatan pencapaian target nasional dan tujuan Sustainable Development Goals (SDGs) 2030 dalam penghapusan segala bentuk malnutrisi.
Co-Authors Anjani, Gemala Etika Ratna Noer Mahabatillah, Desty Nawai, Fatmayanti Stefany, Fadean