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Diza Sartika
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Agriculture, Biological Sciences & Forestry Chemistry

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EFFECTIVENESS THE OINTMENT OF FOREST BETEL LEAVES EXTRACT (Piper aduncum L. ) AGAINST EXCISION WOUNDS Diza Sartika; Ria Afrianti; Rihadhatul Aisy; Miftahur Rahmi
JURNAL KATALISATOR Vol. 9 No. 1 (2024): Jurnal Katalisator Volume 9 No.1, April 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i1.2821

Abstract

Excision wounds are included in open wounds and occupy the top three types of injuries experienced by the public. Forest betel (Piper aduncum L) is one of the plants that can be used in healing excision wounds because it contains several chemical ingredients such as flavonoids, steroids and saponins which can help speed up wound healing. This study aims to determine the effectiveness of ointment extracts of forest betel leaves (Piper aduncum L.) on the healing of excision wounds in male albino rats. Animals are divided into 5 groups there are control group (base used of vaselinflavum ointment), group of forest betel leaf extract concentration 5%, 10%, 15% and the comparison group (Ointment T®). Basting of preparation was done twice a day for 21 days. The parameters observed were the percentage of wound healing, epithelialization time and histopathology. The results showed on the average percentage of excision wound healing on the 7th, 14th and 21st days were control group ( 43.046% , 84.118%, 92.866% ), concentration 5% (45.49%, 87 608%, 94.704%), concentration of 10% (46.196%, 88.24%, 96.692%), concentration of 15% (46.572%, 91.058%, 97.886%) and the comparison group (46.572%, 90.01%, 97.372%). the control group (8 days), 5% concentration (7 days), 10% concentration (6.8 days), 15% concentration (6.4 days) and the comparison group (6.6 days).For the histopathological test, the results of epithelialization, collagen fiber, and fibroblast scores were. respectively the control group (2,2,1), 5% concentration (2,2,2), 10% concentration (2,2,2), 15% concentration (3,3,3) and the comparison group (3 ,3,3). The most effective group for excision wound healing was the 15% concentration group.
FORMULATION AND ANTIBACTERIAL ACTIVITY TEST OF ANTI-ACNE GEL FROM ETHANOL EXTRACT OF SENDUDUK LEAVES (Melastoma malabathricum. L) Novelni, Ringga; Mimi Yupelimi; Dina Agustina; Diza Sartika; Vici Syahril Chairani
JURNAL KATALISATOR Vol. 9 No. 1 (2024): Jurnal Katalisator Volume 9 No.1, April 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i1.2902

Abstract

Treatment of inflamed acne is done by administering antibiotics and chemicals, which can usually cause side effects such as skin irritation and resistance. To avoid this, it can be replaced by doing traditional treatment using natural ingredients. Senduduk plant (Melastoma malabathricum L.) is one of the natural ingredients that can be used to treat acne because it contains secondary metabolites of flavonoids, phenolics, tannins and terpenoids that are very potential as antibacterials. This study aims to determine the ethanol extract of senduduk leaves can be formulated in a physically stable gel dosage form and determine the antibacterial activity against Propionibacterium acne and Staphylococcus aureus bacteria. This study used an experimental method by making 3 types of formulas containing ethanol extract of senduduk leaves (Melastoma malabathricum L.) 1.5%, 2.5% and 3.5%. Furthermore, the evaluation of the gel preparation included organoleptic test, homogeneity test, pH test, spreadability test and adhesion test. Antibacterial activity testing was carried out by the pitting diffusion method using Klindamycin as a positive control. Based on the results of the gel preparation evaluation, it shows that the anti-acne gel preparation has physical quality that meets the standards. Antibacterial activity test of senduduk leaf ethanol extract gel against S.aureus bacteria at concentrations of 1.5%, 2.5% and 3.5% had inhibition zone diameters of 20.3 mm, 21.4 mm, and 24.2 mm, respectively, while against P. acnes bacteria it was 21.6 mm, 25.3 mm, and 26.5 mm. It can be concluded that the anti-acne gel of senduduk leaf ethanol extract has antibacterial activity against S. aureus and P. acnes bacteria and can be made into an anti-acne gel dosage form.
Co-Authors Dina Agustina Miftahur Rahmi Mimi Yupelimi Ria Afrianti Rihadhatul Aisy Ringga Novelni Vici Syahril Chairani