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All Journal Berkala Kedokteran The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science
Putri, Ruth Widhiati Raharjo
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Higher Trace Elements and Lower Fatty Acids Levels in Erythrocytes as Predictors of Preeclampsia Putri, Ruth Widhiati Raharjo; Prasmusinto, Damar; Wibowo, Noroyono; Irwinda, Rima; Purwosunu, Yuditiya; Saroyo, Yudianto Budi
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3256

Abstract

BACKGROUND: Preeclampsia is one of the common causes of maternal death in Indonesia. Many studies only focus on the diagnosis and pharmacological treatment of preeclampsia. However, predictors of preeclampsia need to be observed to add more focus on the etiology and prevention of preeclampsia. The imbalances of trace elements and fatty acids play an important role in preeclampsia. Therefore, this study was conducted to evaluate the status of trace elements and fatty acids in preeclampsia patients as predictors of preeclampsia.METHODS: A cross-sectional study was conducted in 3 hospitals, and involving 40 pregnant women classified into severe preeclampsia and normotensive groups. Trace elements and fatty acids were measured in serum and erythrocytes using Inductively Coupled Plasma and Gas Chromatography-Mass Spectrometry. Serum and erythrocytes fatty acid levels' cut-off value, sensitivity, and specificity were analyzed using Receiver Operating Characteristic (ROC) curve and Area Under the Curve (AUC) value.RESULTS: Serum selenium, manganese, and iron levels were significantly different in the preeclampsia group than in the controls (p<0.05). Of all the heavy metals, higher concentrations of cadmium, arsenic, lead, and mercury were found in preeclampsia groups compared to control. Linoleic acid showed the highest predictive value to increase severe preeclampsia with AUC of 0.8. The ratio of high omega-6/omega-3 increases the risk of preeclampsia.CONCLUSION: Selenium, manganese, iron, cadmium, arsenic, lead, and mercury levels are higher in the serum of preeclampsia patients. Almost all erythrocyte fatty acids were significantly higher in the control group compared to preeclampsia. Measurement of trace elements and fatty acids is needed as a predictor of preeclampsia. Erythrocyte fatty acids measurement is considered better than serum.KEYWORDS: trace elements, fatty acids, preeclampsia
Pregnancy With Multidrug-Resistant Pulmonary Tuberculosis and Autoimmune Hemolytic Anemia Complicated by Intrauterine Growth Restriction - A Case Report Permata, Putri Indah; Aditya, Renny; Putri, Ruth Widhiati Raharjo; Isa, Mohamad; Kurniawan, Sigit Prasetia; Nurrasyidah, Ira
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.878

Abstract

AbstractIntroductionIntrauterine growth restriction (IUGR) is a major obstetric complication often caused by maternal infections and anemia. We present a case of IUGR in a pregnant woman caused by multidrug-resistant tuberculosis (MDR-TB) and autoimmune hemolytic anemia (AIHA).Case presentationA 37-year-old G5P2A2 woman with confirmed MDR-TB and AIHA was treated with levofloxacin, clofazimine, cycloserine, ethambutol, bedaquiline, and methylprednisolone. Fetal biometry showed estimated fetal weight below the 10th percentile, with a significantly declining growth curve thereafter. After administration of fetal lung maturation at 33 – 34 weeks, she underwent an elective cesarean section at 35 – 36 weeks. A female infant weighing 1,840g was delivered. The treatment for MDR-TB and AIHA in the mother was continued afterward.ConclusionPregnancies complicated by MDR-TB and AIHA require strict monitoring and individualized multidisciplinary treatment. Further research is needed to establish treatment strategies that improve maternal and fetal outcomes in similar cases.Keywords : Autoimmune hemolytic anemia; intrauterine growth restriction; multidrug resistance; pregnancy; tuberculosis. Kehamilan dengan Tuberkulosis Paru Resisten Obat Ganda dan Anemia Hemolitik Autoimun yang Diperberat oleh Pertumbuhan Janin Terhambat – Laporan Kasus AbstrakPendahuluanIUGR adalah komplikasi obstetrik yang dapat disebabkan infeksi dan anemia pada maternal. Pada kasus ini dipresentasikan kasus wanita hamil dengan IUGR yang disebabkan multidrug resistant TB (MDR-TB) dan autoimmune hemolytic anemia (AIHA).Ilustrasi kasusIbu hamil 37 tahun G5P2A2 datang dengan TB-MDR dan AIHA. Pasien menjalani terapi TB-MDR dengan levofloksasin, klofazimin, sikloserin, etambutol, dan bedaquiline, serta metilprednisolon untuk AIHA. Pada fetal biometri ditemukan estimated fetal weight (EFW) di bawah 10 persentil dengan kurva pertumbuhan janin menurun signifikan setelahnya. Setelah dilakukan induksi pematangan paru janin pada usia kehamilan 33 - 34 minggu,  operasi sesar elektif dilakukan pada usia kehamilan 35 – 36 minggu melahirkan bayi perempuan dengan berat janin 1840gram. Pengobatan TB-MDR dan AIHA pada ibu dilanjutkan setelahnya.KesimpulanKehamilan dengan TB dan AIHA memerlukan pemantauan ketat dan terapi multidisiplin yang terindividualisasi. Penelitian lebih lanjut diperlukan.Kata kunci : Hemolitik anemia autoimun; kehamilan; pertumbuhan janin terhambat; resisten obat; tuberkulosis.
Exploring the Link Between Severe Preeclampsia and Asymptomatic Urinary Tract Infections in the Third Trimester: A Cross-Sectional Study Abimanyu, Bambang; Budinurdjaja, Pribakti; Radam, M. Robyanoor Ahyadi; Putri, Ruth Widhiati Raharjo; Sauqi, Hardyan; Sabaruddin, Hermin; Vamela, Agatha
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.25138

Abstract

Urinary tract infection (UTI) is prevalent in women between 16 and 35 years old. UTI occurs in 2%-7% of pregnant women and affects the inflammatory process, which damages the vascular endothelium by decreasing nitric oxide (NO). This condition is evident in pregnant women with preeclampsia. This research aims to determine the relationship between urinary tract infections and preeclampsia in the third trimester of pregnancy in the delivery room at Ulin Regional Hospital Banjarmasin from January to December 2023. This study's design was cross-sectional observational using secondary data, including patient registers and medical record data. The sample included those who came in with labor, not labor and post-partum conditions for any causes and third-trimester pregnant patients diagnosed with UTI and Severe Preeclampsia in the delivery room of Ulin Regional Hospital, Banjarmasin and use chi-square test for each category. The 119 total pregnant patients with UTI in the third trimester arriving in the delivery room, 73 of them were diagnosed with preeclampsia. Most of them were under 35 yo. A total of 48 patients had multigravida status in all cases of UTI in preeclampsia in the third trimester of pregnancy. The chi-square analysis of the relationship and preeclampsia in pregnant women in the third trimester with p-value of 0.000, and the Odds ratio value was 4.4. Third-trimester pregnant women who suffer from urinary tract infections are 4.4 times more likely to experience preeclampsia.
Co-Authors Abimanyu, Bambang Budinurdjaja, Pribakti Damar Prasmusinto Hardyan Sauqi Ira Nurrasyidah Isa, Mohamad Kurniawan, Sigit Prasetia Noroyono Wibowo Permata, Putri Indah Purwosunu, Yuditiya Radam, M. Robyanoor Ahyadi Renny Aditya Rima Irwinda, Rima Sabaruddin, Hermin Saroyo, Yudianto Budi Vamela, Agatha