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All Journal The Indonesian Biomedical Journal Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Purwosunu, Yuditiya
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Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Feasibility Study For Birth Defect’s and Congenital Abnormalities’s Integrated Service In A Low-Middle Income Country Saroyo, Yudianto Budi; Firmansha Dilmy, Mohammad Adya; Salsabila Putri, Cut Tisya; Islamah, Rachelya Nurfirdausi; Budiman, Jenica Xaviera; Rumondang, Amanda; Purwosunu, Yuditiya; Irwinda, Rima; Rohsiswatmo, Rinawati
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 3 July 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i3.2783

Abstract

Background: Congenital abnormalities are anatomical and physiological abnormalities that are present in babies from birth. One of the main causes of high infant mortality and neonatal mortality in Indonesia is congenital abnormalities in babies. This study describes the prevalence of congenital abnormalities in Dr. Cipto Mangunkusumo Hospital, as a tertiary referral hospital in Indonesia, which requires integrated healthcare service to be treated well. Methods: Data obtained from 323 patients at Dr. Cipto Mangunkusumo General Hospital are collected in a year, to be further analyzed in retrospective cohort study. Collected data includes the patients’ age, birth date, reproductive history, gestational age, and congenital abnormalities of the baby. Results: The data shows that patients with the age group of 30-39 years old dominated the cases of pregnancy with congenital abnormalities. Cases are also more dominant in the gestational age of 13 – 28 weeks (second-trimester). Most cases of abnormalities are from the central nervous system with 159 cases and followed by cardiovascular system with 130 cases. Overall prevalence of congenital abnormalities are detected within patients during prenatal screening in Dr. Cipto Mangunkusumo General Hospital. Conclusion: This study highlights the importance in managing congenital abnormalities and birth defects by developing an integrated service in the healthcare system to lower infant and neonatal mortality. Keywords: birth defect, congenital abnormalities, prenatal screening
Higher Trace Elements and Lower Fatty Acids Levels in Erythrocytes as Predictors of Preeclampsia Putri, Ruth Widhiati Raharjo; Prasmusinto, Damar; Wibowo, Noroyono; Irwinda, Rima; Purwosunu, Yuditiya; Saroyo, Yudianto Budi
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3256

Abstract

BACKGROUND: Preeclampsia is one of the common causes of maternal death in Indonesia. Many studies only focus on the diagnosis and pharmacological treatment of preeclampsia. However, predictors of preeclampsia need to be observed to add more focus on the etiology and prevention of preeclampsia. The imbalances of trace elements and fatty acids play an important role in preeclampsia. Therefore, this study was conducted to evaluate the status of trace elements and fatty acids in preeclampsia patients as predictors of preeclampsia.METHODS: A cross-sectional study was conducted in 3 hospitals, and involving 40 pregnant women classified into severe preeclampsia and normotensive groups. Trace elements and fatty acids were measured in serum and erythrocytes using Inductively Coupled Plasma and Gas Chromatography-Mass Spectrometry. Serum and erythrocytes fatty acid levels' cut-off value, sensitivity, and specificity were analyzed using Receiver Operating Characteristic (ROC) curve and Area Under the Curve (AUC) value.RESULTS: Serum selenium, manganese, and iron levels were significantly different in the preeclampsia group than in the controls (p<0.05). Of all the heavy metals, higher concentrations of cadmium, arsenic, lead, and mercury were found in preeclampsia groups compared to control. Linoleic acid showed the highest predictive value to increase severe preeclampsia with AUC of 0.8. The ratio of high omega-6/omega-3 increases the risk of preeclampsia.CONCLUSION: Selenium, manganese, iron, cadmium, arsenic, lead, and mercury levels are higher in the serum of preeclampsia patients. Almost all erythrocyte fatty acids were significantly higher in the control group compared to preeclampsia. Measurement of trace elements and fatty acids is needed as a predictor of preeclampsia. Erythrocyte fatty acids measurement is considered better than serum.KEYWORDS: trace elements, fatty acids, preeclampsia
Studi Ekspresi Glukosa Transporter pada Preeklampsia dan Hubungannya dengan Gangguan Metabolik pada Ibu Hamil Fairuz, Vycka Fikriyani; Saroyo, Yudianto Budi; Purwosunu, Yuditiya
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i2.55163

Abstract

Gangguan metabolik merupakan masalah kesehatan global yang ditandai dengan obesitas, resistensi insulin, hipertensi, dan hiperglikemia. Patogenesis sindrom metabolik bersifat multifaktorial, dipengaruhi oleh faktor nutrisi, genetik, dan lingkungan. Pada ibu hamil, gangguan metabolisme akibat obesitas dan hipertensi meningkatkan risiko diabetes melitus gestasional dan preeklamsia. Preeklamsia terjadi akibat gangguan plasenta yang disebabkan oleh defisiensi invasi trofoblas pada arteri spiral miometrium, mengakibatkan iskemia janin. Metabolisme karbohidrat, terutama glukosa, berperan penting dalam patofisiologi preeklamsia. Glukosa merupakan sumber utama energi yang dimetabolisme oleh sel trofoblas plasenta melalui ekspresi glukosa transporter (GLUT) pada jaringan fetomaternal. Tiga jenis GLUT utama yang berperan dalam transport glukosa antara ibu dan janin adalah GLUT1, GLUT3, dan GLUT4. Dalam kondisi preeklamsia, berkurangnya perfusi plasenta dan hipoksia menyebabkan gangguan ekspresi GLUT, sehingga transport glukosa ke janin menurun. Akibatnya, terjadi keterbatasan pertumbuhan janin serta peningkatan risiko komplikasi lainnya. Studi ini bertujuan untuk memahami hubungan antara ekspresi GLUT dan preeklamsia guna mengidentifikasi potensi intervensi terapeutik yang dapat meningkatkan transport glukosa ke janin. Hasil penelitian menunjukkan bahwa gangguan regulasi GLUT pada preeklamsia berkontribusi terhadap restriksi pertumbuhan janin. Kesimpulannya, pemahaman lebih lanjut mengenai ekspresi GLUT dalam preeklamsia dapat berkontribusi pada pengembangan strategi pengobatan yang lebih efektif untuk meningkatkan kesehatan ibu dan janin.
Co-Authors Budiman, Jenica Xaviera Damar Prasmusinto Fairuz, Vycka Fikriyani Firmansha Dilmy, Mohammad Adya Islamah, Rachelya Nurfirdausi Noroyono Wibowo Putri, Ruth Widhiati Raharjo Rima Irwinda, Rima Rinawati Rohsiswatmo Rumondang, Amanda Salsabila Putri, Cut Tisya Saroyo, Yudianto Budi